Results 61 to 70 of about 70,995 (337)
Parsimonious numerical modelling of deep geothermal reservoirs [PDF]
, 2015 Numerical modelling has been undertaken to help improve understanding of a deep geothermal system being considered for development in the vicinity of Eastgate (Weardale, County Durham, UK).
Fairs, Tim H. +2 more
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
, 2013 Breedon Hill forms one of the most prominent features in the landscape of north-west Leicestershire, standing up 50 m above the surrounding ground. That it has been a major landmark throughout recorded history is suggested by its name, which is derived ...
Ambrose, Keith
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
A reconnaissance geochemical drainage survey of the Criffel-Dalbeattie granodiorite complex and its environs [PDF]
, 1977 Regional geochemical reconnaissance by stream sediments and panned concentrates was undertaken over an area of 850 km 2 of south-west Scotland. Rocks of Ordovician to Permian age are exposed within the area but the major part is occupied by the ...
Brown, M.J. +3 more
core
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
The Upper Palaeozoic pebbly mudstone facies of peninsular Thailand and western Malaysia - Continental margin deposits of Palaeoeurasia [PDF]
, 1986 Die devonische bis unterpermlsche Phuket Group in Thailand und deren Äquivalent in Malaysia, die Singha Formation, gehören zum SE-asiatischen "pebbly mudstone Gürtel", welcher sich vom südlichen Tibet bis Sumatra erstreckt. Diese ca.
Altermann, Wladyslaw
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
New basal Odonatoptera (Insecta) from the lower Carboniferous (Serpukhovian) of Argentina [PDF]
, 2016 Nuevos Odonatoptera basales del Serpukhoviano superior (325-324 Ma) son descriptos de la localidad Guandacol 1, Quebrada de las Libélulas, Formación Guandacol, provincia de La Rioja, centro oeste de la Argentina.
Gutierrez, Pedro Raul +1 more
core