Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration. [PDF]
Angew Chem Int Ed EnglThe nitrosuccinate lyase CreD catalyzes C–NO2 bond formation using nitrite in water and shows synthetic practicality with high turnover numbers up to 102,000. A combination of protein engineering and computational methods helped to reveal the mechanistic principles that underpin this unique enzymatic activity.
Aleotti M +9 more
europepmc +3 more sources
Structural instability impairs function of the UDP-xylose synthase 1 Ile181Asn variant associated with short-stature genetic syndrome in humans. [PDF]
FEBS LettThe Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Li T, Sánchez-Murcia PA, Nidetzky B.
europepmc +2 more sources
Classificação do diabete melito Diabetes mellitus classification
Arquivos Brasileiros de Cardiologia, 2010 A correta classificação do diabete melito (DM) permite o tratamento mais adequado e compreende quatro categorias: DM tipo 1; DM tipo 2; Outros tipos e Diabete Gestacional.
Jorge de Faria Maraschin +3 more
doaj +1 more source
, 1996 1-14CHamamelose (2-hydroxymethyl-D-ribose) was synthesized by reaction of ribulose 5-phosphate with potassium 14Ccyanide, catalytic hydrogenation of the resulting cyanohydrin, and dephosphorylation of the product.
Wayne Martindale (17162908) +4 more
core +3 more sources
Alginate Lyases from Marine Bacteria: An Enzyme Ocean for Sustainable Future
, 2022 The cell wall of brown algae contains alginate as a major constituent. This anionic polymer is a composite of β-d-mannuronate (M) and α-l-guluronate (G).
Olga Babich +13 more
core +1 more source
High resolution MS2 analyses of 12-carboxy-JA and 12-carboxy-JA-Ile.
, 2016 UHPLC-ESI QTOF-MS fragmentation analyses of metabolite markers depleted in flowers with impaired CYP94C1 functionality. MS2 spectra of A) 12-carboxy-JA (m/z 239.0948, RT 3.53 min) and B) 12-carboxy-JA-Ile (m/z 352.1814, RT 4.50 min) are shown for ...
Viktoria Bruckhoff (3147780) +5 more
core +1 more source
Exploring glutathione lyases as biocatalysts: paving the way for enzymatic lignin depolymerization and future stereoselective applications [PDF]
, 2015 Glutathione-dependent β-etherases and glutathione lyases are key-enzymes for the biocatalytic depolymerization of lignin. In the first step, the nucleophilic attack of glutathione to the common β-O-4-arylether motif in lignin is catalyzed by β-etherases ...
Sevenich, Marc +3 more
core +3 more sources
The impact of carboxy nitroxide antioxidants on irradiated ataxia telangiectasia cells [PDF]
, 2004 Three water-soluble carboxy nitroxide antioxidants, 5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl, 4-carboxy-2,2,6,6-tetramethylpiperidin-1-yloxyl, and 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl, show significant impact on the postirradiation ...
Hosokawa, K +7 more
core +1 more source
Synthesis of Oligonucleotides Containing 5-Carboxy-2‘-deoxyuridine at Defined Sites
, 2016 Synthesis of Oligonucleotides Containing 5-Carboxy-2‘-deoxyuridine at Defined ...
T. Berthod (3037890) +4 more
core +1 more source
Food Biomacromolecules, EarlyView.Chitosan oligosaccharides postharvest treatment effectively preserved quality, enhanced disease resistance, and increased shelf life of fruit. Abstract Different concentrations of chitosan oligosaccharide (COS) (T0: Control, T1: 50 mg/L, T2: 100 mg/L, T3: 250 mg/L, T4: 500 mg/L, and T5: 1000 mg/L COS) were used to investigate the effects of this ...
Santosh Kumar Bose +2 more
wiley +1 more source