Results 31 to 40 of about 30,254 (254)

Weekly irinotecan in a patient with metastatic colorectal cancer on hemodialysis due to chronic renal failure [PDF]

, 2002
Background: The cytotoxic treatment of patients suffering from advanced or metastatic cancer undergoing hemodialysis due to chronic renal failure still remains a problem, since for those patients pharmacokinetic and pharmacodynamic data on most cytotoxic
Hacker, U., Heinemann, Volker, Schalhorn, A., Stemmler, J., Weise, A.   +4 more
core   +1 more source

Predicting the Effects of CYP2C19 and Carboxylesterases on Vicagrel, a Novel P2Y12 Antagonist, by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach

Frontiers in Pharmacology, 2020
Vicagrel, a novel acetate derivative of clopidogrel, exhibits a favorable safety profile and excellent antiplatelet activity. Studies aim at identifying genetic and non-genetic factors affecting vicagrel metabolic enzymes Cytochrome P450 2C19 (CYP2C19 ...
Shuaibing Liu, Ziteng Wang, Xin Tian, Weimin Cai   +3 more
doaj   +1 more source

The low intestinal and hepatic toxicity of hydrolyzed fumonisin B1 correlates with its inability to alter the metabolism of sphingolipids [PDF]

, 2012
Fumonisins are mycotoxins frequently found as natural contaminants in maize, where they are produced by the plant pathogen Fusarium verticillioides. They are toxic to animals and exert their effects through mechanisms involving disruption of sphingolipid
Bracarense, Ana-Paula, Cossalter, Anne-Marie, Grenier, Bertrand, Kolf-Clauw, Martine, Moll, Wulf-Dieter, Oswald, Isabelle P, Schatzmayr, Gerd, Schwartz, Heidi-Elisabeth, Trumel, Catherine   +8 more
core   +2 more sources

Arabidopsis Carboxylesterase 20 Binds Strigolactone and Increases Branches and Tillers When Ectopically Expressed in Arabidopsis and Maize

Frontiers in Plant Science, 2021
Severe drought stress can delay maize silk emergence relative to the pollen shedding period, resulting in poor fertilization and reduced grain yield. Methods to minimize the delay in silking could thus improve yield stability.
Keith Roesler, Cheng Lu, Jill Thomas, Qingzhang Xu, Peter Vance, Zhenglin Hou, Robert W. Williams, Lu Liu, Michaela A. Owens, Jeffrey E. Habben   +9 more
doaj   +1 more source

Equine recurrent uveitis - A spontaneous horse model of uveitis [PDF]

, 2008
Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis.
Altmann, Frank, Amann, Barbara, Deeg, Cornelia A., Hauck, Stefanie M., Pompetzki, Dirk, Raith, Albert, Schmalzl, Thomas, Stangassinger, Manfred, Ueffing, Marius   +8 more
core   +1 more source

Functional Characterization of two Carboxylesterase Genes Involved in Pyrethroid Detoxification in Helicoverpa armigera.

Journal of Agricultural and Food Chemistry, 2020
Insect carboxylesterases are major enzymes involved in metabolism of xenobiotics including insecticides. Two carboxylesterase genes, CarE001A and CarE001H, were cloned from the destructive agricultural pest Helicoverpa armigera.
Yong-Qiang Li, Li-Sha Bai, Cai-Xia Zhao, Jing-jing Xu, Zhongrong Sun, Yan-ling Dong, Dexian Li, Xili Liu, Zhi-Qing Ma   +8 more
semanticscholar   +1 more source

Transcriptional cellular responses in midgut tissue of Aedes aegypti larvae following intoxication with Cry11Aa toxin from Bacillus thuringiensis. [PDF]

, 2015
BackgroundAlthough much is known about the mechanism of action of Bacillus thuringiensis Cry toxins, the target tissue cellular responses to toxin activity is less understood.
Bravo, Alejandra, Cancino-Rodezno, Angeles, Canton, Pablo Emiliano, Gill, Sarjeet S, Soberón, Mario   +4 more
core   +1 more source

Microbial Cell Factories / Pichia pastoris Aft1 - a novel transcription factor, enhancing recombinant protein secretion [PDF]

, 2014
Background: The methylotrophic yeast Pichia pastoris is frequently used for the production of recombinant proteins. However, expression levels can vary depending on the target protein.
Buchetics, Markus, Gasser, Brigitte, Kotz, Daniela, Mattanovich, Diethard, Naschberger, Stefan, Pichler, Harald, Ruth, Claudia, Vidimce, Viktorija   +7 more
core   +5 more sources

Occurrence of target-site resistance to neonicotinoids in the aphid Myzus persicae in Tunisia, and its status on different host plants [PDF]

, 2018
This is the peer reviewed version of the following article: Kamel Charaabi, Sonia Boukhris-bouhachem, Mohamed Makni, and Ian Denholm, ‘Occurrence of target‐site resistance to neonicotinoids in the aphid Myzus persicae in Tunisia, and its status on ...
Bass, Bass, Bass, Bass, Black, Blackman, Blackman, Blackman, Charaabi, Devonshire, Fekih Hassen, Field, Fontaine, Ilias, Katis, Little, Margaritopoulos, Martinez-Torres, Moores, Mottet, Nabeshima, Panini, Puinean, Puinean, Raboudi, Slater, Vorburger, Vorburger, Voudouris   +28 more
core   +2 more sources

Autotransporter domain-dependent enzymatic analysis of a novel extremely thermostable carboxylesterase with high biodegradability towards pyrethroid pesticides

Scientific Reports, 2017
The EstPS1 gene, which encodes a novel carboxylesterase of Pseudomonas synxantha PS1 isolated from oil well-produced water, was cloned and sequenced.
Xianghai Cai, Wei Wang, Lin Lin, Dannong He, Gang Huang, Yaling Shen, Wei Wei, Dongzhi Wei   +7 more
doaj   +1 more source