Results 51 to 60 of about 30,254 (254)

Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin

Frontiers in Pharmacology, 2019
Paeoniflorin, the main component of Xiaoyao Wan, presents low oral bioavailability and unclear antidepressant mechanism. To elucidate the potential reasons for the low bioavailability of paeoniflorin and explore its antidepressant mechanism from the ...
Jin-Bo Yu, Jin-Bo Yu, Zhen-Xiong Zhao, Ran Peng, Li-Bin Pan, Jie Fu, Shu-Rong Ma, Pei Han, Lin Cong, Zheng-Wei Zhang, Li-Xin Sun, Jian-Dong Jiang, Yan Wang   +12 more
doaj   +1 more source

Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with carcinogenesis [PDF]

, 2006
Common fragile sites (cfs) are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Several investigations support the view that common fragile sites play a role in carcinogenesis.
A Caputo, A Matsuyama, A Musio, Alda Maria Puliti, AM Casper, Angela Re, CD Hou, CT Miller, D Corà, D Corà, D Iliopoulos, Davide Cora, E Birney, H Ishii, I Sbrana, I Sbrana, Isabella Sbrana, ISCN, J Bartkova, J Hoshen, K Mimori, KA Cimprich, KA Nyberg, LV O'Keefe, M Ashburner, M Fabbri, M Schwartz, Michele Caselle, Newman MEJ, NS Chang, P Hoglund, RS Cha, S Corbin, S Gasser, SL Reiner, T Oyama, TW Glover, U Krummrei, VG Gorgoulis, Y Zhu   +39 more
core   +5 more sources

Endoplasmic reticulum targeting ratiometric fluorescent probe for carboxylesterase 2 detection in drug-induced acute liver injury.

Analytical Chemistry, 2019
Carboxylesterase 2 (CES2) an endoplasmic reticulum (ER) located phaseⅠenzyme plays a vital role in the metabolism of various endogenous and exogenous substances and is regarded as an important target for the design of prodrugs.
Xiangge Tian, Fei Yan, Jingyuan Zheng, X. Cui, Lei Feng, Sheng Li, Lingling Jin, T. James, Xiaochi Ma   +8 more
semanticscholar   +1 more source

Reactivity of a Recombinant Esterase from Thermus thermophilus HB27 in Aqueous and Organic Media

Microorganisms, 2022
The thermoalkalophilic membrane-associated esterase E34Tt from Thermus thermophilus HB27 was cloned and expressed in Kluyveromyces lactis (KLEST-3S esterase). The recombinant enzyme was tested as a biocatalyst in aqueous and organic media. It displayed a
Roberto González-González, Pablo Fuciños, Elisa Beneventi, Olalla López-López, Begoña Pampín, Ramón Rodríguez, María Isabel González-Siso, Jacobo Cruces, María Luisa Rúa   +8 more
doaj   +1 more source

Mesenchymal stem cells as vectors for lung cancer therapy [PDF]

, 2013
Despite recent advances in treatment, lung cancer accounts for one third of all cancer-related deaths, underlining the need of development of new therapies.
Janes, SM, Kolluri, KK, Laurent, GJ
core   +1 more source

Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators

Drug Metabolism And Disposition, 2019
Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers, comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80%–95% of total hydrolytic activity in the liver and plays a crucial role in the ...
Lucy Her, Hao‐Jie Zhu
semanticscholar   +1 more source

Hydrolytic Fate of 3/15-Acetyldeoxynivalenol in Humans: Specific Deacetylation by the Small Intestine and Liver Revealed Using in Vitro and ex Vivo Approaches

Toxins, 2016
In addition to deoxynivalenol (DON), acetylated derivatives, i.e., 3-acetyl and 15-acetyldexynivalenol (or 3/15ADON), are present in cereals leading to exposure to these mycotoxins.
El Hassan Ajandouz, Stéphane Berdah, Vincent Moutardier, Thierry Bege, David Jérémie Birnbaum, Josette Perrier, Eric Di Pasquale, Marc Maresca   +7 more
doaj   +1 more source

The structure of a novel thermophilic esterase from the planctomycetes species, thermogutta terrifontis reveals an open active site due to a minimal 'cap' domain. [PDF]

, 2015
Published under the CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and the source are credited.A carboxyl esterase (TtEst2) has been identified in a novel thermophilic bacterium,
Ingham, C, Isupov, MN, Littlechild, JA, Sayer, Christopher, Szabo, Z   +4 more
core   +1 more source

Remdesivir potently inhibits carboxylesterase‐2 through covalent modifications: signifying strong drug‐drug interactions

Fundamental & Clinical Pharmacology, 2020
Remdesivir was recently approved to treat COVID‐19. While this antiviral agent delivers clinical benefits, several safety concerns in many cases have been raised. This study reports that remdesivir at nanomolar concentrations inhibits carboxylesterase‐2 (
Yuemao Shen, William Eades, B. Yan
semanticscholar   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source