Results 61 to 70 of about 30,254 (254)

A carboxylesterase, Esterase-6, modulates sensory physiological and behavioral response dynamics to pheromone in Drosophila [PDF]

, 2012
Conclusions: Our study presents evidence that Est-6 plays a role in the physiological and behavioral dynamics of sex pheromone response in Drosophila males and supports a role of Est-6 as an odorant-degrading enzyme (ODE) in male antennae.
Chertemps, Thomas, Dekker, Teun, Durand, Nicolas, Francois, Adrien, Lucas, Philippe, Maibeche-Coisne, Martine, Rosell, Gloria   +6 more
core  

Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate [PDF]

, 2017
Tenofovir disoproxil fumarate (TDF), a prodrug of tenofovir, has oral bioavailability (25%) limited by intestinal transport (P-glycoprotein), and intestinal degradation (carboxylesterase). However, the influence of luminal pancreatic enzymes is not fully
Domanico, P, Hobson, J, Moss, DM, Owen, A, Rajoli, RKR, Randolph, R, Rannard, S, Seonghee, P, Siccardi, M, Watkinson, M, Wring, S   +10 more
core   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny [PDF]

Drug Metabolism and Disposition, 2016
Human hepatic carboxylesterase 1 and 2 (CES1 and CES2) are important for the disposition of ester- and amide-bond-containing pharmaceuticals and environmental chemicals. CES1 and CES2 ontogeny has not been well characterized, causing difficulty in addressing concerns regarding juvenile sensitivity to adverse outcomes associated with exposure to certain
Ronald N Hines, Pippa M Simpson, D. Gail McCarver   +2 more
openaire   +2 more sources

Circadian rhythms in insecticide susceptibility, metabolic enzyme activity, and gene expression in Cimex lectularius (Hemiptera: Cimicidae). [PDF]

, 2019
Many insect species display daily variation of sensitivity to insecticides when they are exposed to the same concentration at different times during the day. To date, this has not been investigated in bed bugs.
Doggett, Stephen L, Khalid, Muhammad Fazli, Lee, Chow-Yang, Veera Singham, G   +3 more
core   +3 more sources

Gut Bacterium Lysinibacillus Sphaericus Exacerbates Aspirin‐induced Intestinal Injury by Production of Carboxylesterase EstB

Advanced Science, EarlyView.
Schematic overview illustrating the detrimental role of gut microbiota in aspirin‐induced intestinal injury. L. sphaericus and its secreted carboxylesterase EstB are identified as key drivers that catalyze aspirin hydrolysis into salicylic acid, thereby exacerbating intestinal injury. Inhibition of EstB by the dietary compound flavanomarein effectively
Zeyu Zhao, Qing Li, Xiaowu Bai, Ertao Zhai, Weigang Dai, Yan Qian, Tianhao Zhang, Zhixin Huang, Ziyu Huang, Fangang Meng, Jianhui Chen, Tao Zuo, Shirong Cai, Risheng Zhao   +13 more
wiley   +1 more source

Modulation of paraoxonase 1 and 3 expression after moderate exercise training in the rat

Journal of Lipid Research, 2009
Paraoxonases (PONs) are a small family of antioxidant enzymes whose antiatherogenic activity is well known. The aim of the present study was the evaluation of the effects of moderate aerobic training on their expression using a rat model.
Rita Romani, Gianna Evelina De Medio, Simona di Tullio, Rosa Lapalombella, Irene Pirisinu, Vittoria Margonato, Arsenio Veicsteinas, Marina Marini, Gabriella Rosi   +8 more
doaj   +1 more source

Identification, Characterization, and Preliminary X-ray Diffraction Analysis of a Novel Esterase (ScEst) from Staphylococcus chromogenes

Crystals, 2022
Ester prodrugs can develop novel antibiotics and have potential therapeutic applications against multiple drug-resistant bacteria. The antimicrobial activity of these prodrugs is activated after being cleaved by the esterases produced by the pathogen ...
Jisub Hwang, Sangeun Jeon, Min Ju Lee, Wanki Yoo, Juwon Chang, Kyeong Kyu Kim, Jun Hyuck Lee, Hackwon Do, T. Doohun Kim   +8 more
doaj   +1 more source

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associated with methylphenidate therapy.
Aline Pasquini Santos, Tatiane Carinta de Souza, Kaio Evandro Cardoso Aguiar, Ana Caroline Alves da Costa, Natasha Monte, Juliana Carla Gomes Rodrigues, Giovanna Gilioli da Costa Nunes, Rita de Cássia Calderaro Coelho, Ândrea Ribeiro‐dos‐Santos, André Maurício Ribeiro dos Santos, Sandro José de Souza, Sidney Emanuel Batista dos Santos, Rommel Mario Rodriguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +14 more
wiley   +1 more source

Peach Carboxylesterase PpCXE1 Is Associated with Catabolism of Volatile Esters.

Journal of Agricultural and Food Chemistry, 2019
Peach fruit volatile acetate esters impact consumer sensory preference and contribute to defense against biotic stresses. Previous studies showed that alcohol acyltransferase (AAT) family PpAAT1 is correlated with volatile ester formation in peach fruits.
Xiangmei Cao, Kaili Xie, Wenyi Duan, Yunqi Zhu, Mingchun Liu, Kun-song Chen, H. Klee, Bo Zhang   +7 more
semanticscholar   +1 more source