Results 81 to 90 of about 30,254 (254)
Biotechnology and Bioengineering, EarlyView.ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier +3 more
wiley +1 more source
Toxins, 2022 Gossypol is a polyphenolic toxic secondary metabolite derived from cotton. Free gossypol in cotton meal is remarkably harmful to animals. Furthermore, microbial degradation of gossypol produces metabolites that reduce feed quality.
Li Zhang +6 more
doaj +1 more source
A personal 360° view of applications of ‘biomimetic’ molecular recognition
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley +1 more source
Pharmaceutics, 2013 The use of a prodrug, a conjugate of an active drug with a lipophilic substituent, is a good way of increasing the cutaneous absorption of a drug. However, the activity of dermal hydrolases has rarely been investigated in humans, or experimental animals.
Harunobu Iwase +3 more
doaj +1 more source
RAPD PCR Confirms Absence of Genetic Variation Between Insecticide Resistant Variants of the Green Peach Aphid, \u3ci\u3eMyzus Persicae\u3c/i\u3e (Homoptera: Aphididae) [PDF]
, 2017 Previous allozyme analysis has revealed an apparent absence of enzyme variability in the green peach aphid, Myzus persicae (Sulzer). We are interested in determining the genetic relatedness of individual M persicae clones carrying different numbers of ...
Al-Aboodi, A., Ffrench-Constant, R. H
core +2 more sources
Molecular Carcinogenesis, EarlyView.ABSTRACT 5‐Methylcytosine (m5C) RNA modification contributes to tumor initiation and progression. However, its transcriptome‐wide distribution patterns and biological implications in hepatitis B virus (HBV)‐negative hepatocellular carcinoma (HCC) remain poorly understood.
Tianhan Sun +12 more
wiley +1 more source
Human carboxylesterases: a comprehensive review
Acta Pharmaceutica Sinica B, 2018 Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism of a wide variety of endogenous esters, ester-containing drugs and ...
Dandan Wang +5 more
openaire +3 more sources
Malathion Resistance in Larvae of Some Southern Minnesota Populations of the Indianmeal Moth,\u3ci\u3e Plodia Interpunctella\u3c/i\u3e (Lepidoptera: Pyralidae), Infesting Bulk-Stored Shelled Corn [PDF]
, 2017 Larvae of 21 field collected populations of the Indianmeal moth, Plodia interpunctella, infesting stored shelled corn in southern Minnesota were tested for their susceptibility to malathion in the laboratory.
Harein, P. K +2 more
core +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai +6 more
wiley +1 more source
Carboxylesterase-Cleavable Biotinylated Nanoparticle for Tumor-Dual Targeted Imaging
Theranostics, 2019 Near-infrared (NIR) nanoprobes with fluorescence “Turn-On” property are advantageous in cancer diagnosis but, to the best of our knowledge, “smart” nanoprobe that simultaneously targets both biotin receptor and carboxylesterase (CES) for HepG2 tumor-dual
Peiyao Chen +7 more
semanticscholar +1 more source