Results 91 to 100 of about 27,172,362 (207)

Bisphenol A‐associated alterations in the expression and epigenetic regulation of genes encoding xenobiotic metabolizing enzymes in human fetal liver [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106679/1/em21823 ...
Dolinoy, Dana C., Kim, Jung H., Nahar, Muna S., Sartor, Maureen A.   +3 more
core   +1 more source

A structural examination of agrochemical processing by human carboxylesterase 1

Journal of Pesticide Science, 2010
Human carboxylesterase 1 (hCE1) is the primary carboxylesterase expressed in the liver. This critical member of the phase I drug metabolism pathway detoxifies a wide-range of endobiotics, xenobiotics, and agrochemicals. To date, more than a dozen X-ray crystal structures have been elucidated of hCE1 in complex with a broad spectrum of ligands ...
Redinbo, Matthew, Hemmert, Andrew
openaire   +2 more sources

Engaging Gut‐to‐Brain Signalling to Treat Alcohol Use Disorder

Addiction Biology, Volume 31, Issue 3, March 2026.
ABSTRACT According to the 2023 National Survey on Drug Use and Health (NSDUH), 28.9 million people ages 12 and older in the United States had alcohol use disorder (AUD) in the past year. Although chronic alcohol use contributes to numerous health disorders as well as being an economic burden, there are few medications approved for treatment of AUD, and
Paula L. Hoffman, Giordano de Guglielmo, Valentina Vengeliene, Wolfgang Kunze, Christina L. Lebonville, Jerome D. Swinny, Amanda J. Roberts, Olivier George, Karen‐Anne McVey Neufeld, Alexandra Dunbar, Laura M. Saba, Ruolin Ma, Leandro F. Vendruscolo, Howard C. Becker, Rainer Spanagel, Boris Tabakoff   +15 more
wiley   +1 more source

The specificity of neuroprotection by antioxidants [PDF]

, 2009
Background Reactive oxygen species (ROS) play an important role in aging and age-related diseases such as Parkinson's disease and Alzheimer's disease.
Yuanbin Liu, David R Schubert
core   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

QuaDMutEx: quadratic driver mutation explorer [PDF]

, 2017
Background Somatic mutations accumulate in human cells throughout life. Some may have no adverse consequences, but some of them may lead to cancer. A cancer genome is typically unstable, and thus more mutations can accumulate in the DNA of cancer cells ...
Arodz, Tomasz Jakub, Yahya, Bokhari
core   +1 more source

Bioactive lipid metabolism by carboxylesterase 1 (CES1) in macrophages (LB154)

The FASEB Journal, 2014
Human carboxylesterases (CES) have an emerging role in lipid metabolism. CES1 in macrophages is a hydrolase with broad endogenous substrate specificity, including cholesteryl ester, triacylglycerol, and 2‐arachidonoylglycerol (2‐AG), which may be relevant to cardiovascular disease and other pathologies related to lipid metabolism dysfunction.
Lee Mangum, Abdolsamad Borazjani, John Crow, Matthew Ross   +3 more
openaire   +1 more source

The Rhus chinensis Genome Provides Insights Into Tannin, Flavonoid Biosynthesis, and Glandular Trichome Development

Plant Biotechnology Journal, Volume 24, Issue 3, Page 988-1013, March 2026.
ABSTRACT The “salt tree”, Rhus chinensis, holds significant economic and medicinal value due to its ability to produce Galla chinensis (Chinese gall/gallnut), a plant‐derived medicinal material used in both traditional Chinese and modern medicine that is rich in tannins and flavonoids. It is also renowned for its remarkable stress tolerance.
Zhaogeng Lu, Helin Zou, Jiawen Cui, Tongfei Wang, Lingyu Ma, Shixiong Ren, Yiwei Cao, Xi Zhang, Zixi Chen, Hongyan Bao, Ling Zhu, Yaning Cui, Ruili Li, Xiuyan Yang, Qikun Zhang, Zhili Wang, Wangxiang Zhang, Li Wang, Jinxing Lin, Biao Jin   +19 more
wiley   +1 more source

Enzyme characteristics of aminotransferase FumI of Sphingopyxis sp. MTA144 for deamination of hydrolyzed fumonisin B1 [PDF]

, 2011
Fumonisins are carcinogenic mycotoxins that are frequently found as natural contaminants in maize from warm climate regions around the world. The aminotransferase FumI is encoded as part of a gene cluster of Sphingopyxis sp.
Christian Hametner, Dietmar Haltrich, Doris Hartinger, Gerd Schatzmayr, Hartinger, Doris, Heidi Schwartz, Wulf-Dieter Moll   +6 more
core   +2 more sources

Characterization of esterase activity from the bacteria, Francisella tularensis, the causative agent of tularemia [PDF]

, 2011
Francisella tularensis is the bacteria responsible for causing the disease tularemia and is listed as one of the top three-biowarfare agents. Among the proteins essential to the virulence and infectivity of F.tularensis are multiple esterases, which are ...
Weston, Leigh Anna
core   +1 more source