Results 151 to 160 of about 27,172,362 (207)

Potential Regulatory Role of Human-Carboxylesterase-1 Glycosylation in Liver Cancer Cell Growth.

Journal of Proteome Research, 2020
We previously reported that human carboxylesterase 1 (CES1), a serine esterase containing a unique N-linked glycosyl group at Asn79 (N79 CES1), is a candidate serological marker of hepatocellular carcinoma (HCC).
Keun Na, Minjoo Kim, Chae-Yeon Kim, Jong-Sun Lim, Jin‐Young Cho, Heon Shin, Hyo Jin Lee, Byeong Jun Kang, D. Han, Hoguen Kim, J. Baik, M. Swiatek‐de Lange, J. Karl, Y. Paik   +13 more
semanticscholar   +1 more source

Lysosome targeting metal-organic framework probe LysFP@ZIF-8 for highly sensitive quantification of carboxylesterase 1 and organophosphates in living cells.

Journal of Hazardous Materials, 2020
Herein, a lysosomal targeting LysFP@ZIF-8 metal-organic framework (MOF) was fabricated using fluorescent protein chromophore-based probe (LysFP) for selectively detection of carboxylesterase 1 (CES1) in living cells.
Baoxing Shen, Xing Zhang, Jianan Dai, Yuan Ji, He Huang   +4 more
semanticscholar   +1 more source

Novel Ratiometric Surface-Enhanced Raman Scattering (SERS) Biosensor for Ultrasensitive Quantitative Monitoring of Human Carboxylesterase-1 in Hepatocellular Carcinoma Cells Using Ag-Au Nanoflowers as SERS Substrate.

Analytical Chemistry
In this study, we developed ratiometric surface-enhanced Raman scattering (SERS) biosensors using Ag-Au alloy nanoflowers as SERS substrates, molecules having amide bonds and alkyne groups (Tag A) as Raman reporters, and sodium thiocyanate as an internal
Hao Cheng, Rui-yun Chen, Yaqin Zhan, Wuheng Dong, Qiying Chen, Ying Wang, Pei Zhou, Si Gao, Wenyi Huang, Lijun Li, Jun Feng   +10 more
semanticscholar   +1 more source

Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD

Neuropharmacology, 2009
Methylphenidate (MPH) is the most frequently prescribed drug in the treatment of attention deficit hyperactivity disorder (ADHD). Several pharmacogenetic studies suggested that catecholamine candidate genes influence individual MPH-responses, but these results are mostly contradictory.
Zsofia, Nemoda, Nora, Angyal, Zsanett, Tarnok, Julia, Gadoros, Maria, Sasvari-Szekely   +4 more
openaire   +2 more sources

Human carboxylesterase 1: from drug metabolism to drug discovery

Biochemical Society Transactions, 2003
Human carboxylesterase 1 (hCE1) is a serine esterase involved in both drug metabolism and activation, as well as other biological processes. hCE1 catalyses the hydrolysis of heroin and cocaine, and the transesterification of cocaine in the presence of ethanol to the toxic metabolite cocaethylene.
M R, Redinbo, S, Bencharit, P M, Potter
openaire   +2 more sources

Rational Design of a Long-Wavelength Fluorescent Probe for Highly Selective Sensing of Carboxylesterase 1 in Living Systems.

Analytical Chemistry, 2019
Rational design of practical probes with excellent specificity and improved optical properties for a particular enzyme is always a big challenge. Herein, a practical and highly specific fluorescent probe for carboxylesterase 1 (CES1) was rationally ...
Zhenhao Tian, Le-le Ding, Kun Li, Yunqing Song, Tongyi Dou, Jie Hou, Xiangge Tian, Lei Feng, Guangbo Ge, Jingnan Cui   +9 more
semanticscholar   +1 more source

Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 1.

European Journal of Pharmaceutical Sciences, 2020
Human carboxylesterase 1 (hCES1) is a hydrolase that is mainly expressed in the liver and lung and plays the most important role in the metabolic activation of ester-type prodrugs.
Masato Takahashi, Yeon Joo Lee, Teruhiko Kanayama, Yusuke Kondo, Kazuki Nishio, Kota Mukai, M. Haba, M. Hosokawa   +7 more
semanticscholar   +1 more source

Does Clopidogrel Decrease the Efficacy of Carboxylesterase‐1 Prodrugs?

The FASEB Journal, 2020
It has previously been reported that clopidogrel is a potent inhibitor of the carboxylesterase‐1 (CES1) mediated hydrolysis of oseltamivir to its active metabolite based on in vitro inhibition studies. However, clopidogrel undergoes extensive first‐pass hepatic metabolism resulting in 85% of the dose being ...
Steven C. Laizure, Hui He, Roert B. Parker   +2 more
openaire   +1 more source

Sensing carboxylesterase 1 in living systems by a practical and isoform-specific fluorescent probe

Chinese Chemical Letters, 2019
Carboxylesterase 1 (CES1), one of the most abundant serine hydrolases in mammals, has drawn much attentions in recent years, owing to this enzyme involves in many physiological processes via hydrolysis of both endogenous esters and xenobiotic esters ...
Le-le Ding, Zhenhao Tian, Jie Hou, Tongyi Dou, Q. Jin, Dan-Dan Wang, Li-Wei Zou, Ya-di Zhu, Yunqing Song, Jingnan Cui, Guangbo Ge   +10 more
semanticscholar   +1 more source

Carboxylesterase 1 as a Determinant of Clopidogrel Metabolism and Activation

The Journal of Pharmacology and Experimental Therapeutics, 2013
Clopidogrel pharmacotherapy is associated with substantial interindividual variability in clinical response, which can translate into an increased risk of adverse outcomes. Clopidogrel, a recognized substrate of hepatic carboxylesterase 1 (CES1), undergoes extensive hydrolytic metabolism in the liver.
Hao-Jie, Zhu, Xinwen, Wang, Brian E, Gawronski, Bryan J, Brinda, Dominick J, Angiolillo, John S, Markowitz   +5 more
openaire   +2 more sources