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LKM-1 Sera from Autoimmune Hepatitis Patients that Recognize ERp57, Carboxylesterase 1 and CYP2D6
Drug Metabolism and Pharmacokinetics, 2010Liver kidney microsomal antibody type 1 (LKM-1) is a diagnostic marker for autoimmune hepatitis type 2 (AIH-2). Characterization of LKM autoantibodies of patients with AIH-2 demonstrated that a proportion of LKM sera contains autoantibodies which recognize one or more small linear epitopes on cytochrome P450, CYP2D6, an enzyme of drug metabolism ...
Ryo, Komurasaki +5 more
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The Journal of Pharmacology and Experimental Therapeutics, 2006
Oseltamivir is the main medicine recommended by the World Health Organization in anticipation of next influenza pandemic. This anti-influenza viral agent is an ester prodrug, and the antiviral activity is achieved by its hydrolytic metabolite: oseltamivir carboxylate.
Shi, Deshi +7 more
openaire +3 more sources
Oseltamivir is the main medicine recommended by the World Health Organization in anticipation of next influenza pandemic. This anti-influenza viral agent is an ester prodrug, and the antiviral activity is achieved by its hydrolytic metabolite: oseltamivir carboxylate.
Shi, Deshi +7 more
openaire +3 more sources
Tetrahedron, 2018
A N-bromosuccinimide (NBS) mediated decarboxylative sulfonylation of β-keto acids with sodium sulfinates is developed. The transformation exhibits a broad substrate scope and good functional group tolerance.
F. Han +7 more
semanticscholar +1 more source
A N-bromosuccinimide (NBS) mediated decarboxylative sulfonylation of β-keto acids with sodium sulfinates is developed. The transformation exhibits a broad substrate scope and good functional group tolerance.
F. Han +7 more
semanticscholar +1 more source
Involvement of Carboxylesterase 1 and 2 in the Hydrolysis of Mycophenolate Mofetil
Drug Metabolism and Disposition, 2010Mycophenolate mofetil (MMF) is the ester prodrug of the immunosuppressant agent mycophenolic acid (MPA) and is rapidly activated by esterases after oral administration. However, the role of isoenzymes in MMF hydrolysis remains unclear. Although human plasma, erythrocytes, and whole blood contain MMF hydrolytic activities, the mean half-lives of MMF in ...
Nobuhiro, Fujiyama +5 more
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Pharmacological and physiological roles of the carboxylesterase 1 enzyme complex
2023The mammalian carboxylesterase 1 (Ces1/CES1) proteins are enzymes that break down a large number of (pro)drugs. The activity of these enzymes in the body can influence how effective a certain (pro)drug is. Ces1/CES1 enzymes are also known to affect lipid metabolism, thus affecting susceptibility to obesity-related metabolic disease.
openaire +3 more sources
Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
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