Results 161 to 170 of about 1,999 (189)

Nϵ-Carboxymethyllysine in brain aging, diabetes mellitus, and Alzheimer's disease

Free Radical Biology and Medicine, 2004
Oxidative stress has been implicated in the pathophysiology of Alzheimer's disease (AD) and diabetes mellitus (DM). N epsilon-carboxymethyllysine (CML) is an advanced glycation end product (AGE) recently found to be associated with oxidative stress mechanisms.
Girones X, Guimera A, Cruz-Sanchez CZ, Ortega A, Sasaki N, Makita Z, Lafuente JV, Kalaria R, Cruz-Sanchez FF   +8 more
openaire   +3 more sources

Digestibility of extruded proteins and metabolic transit of N ε -carboxymethyllysine in rats

Amino Acids, 2012
Milk proteins are frequently used as supplements in fortified foods. However, processing produces chemical changes which likely affect the nutritional advantage. This study was intended to explore the possible difference in digestibility between extruded and non-extruded caseins and how the dietary N (ε) -carboxymethyllysine (CML) is metabolised ...
Issam, Alamir, Céline, Niquet-Leridon, Philippe, Jacolot, Camille, Rodriguez, Martine, Orosco, Pauline M, Anton, Frédéric J, Tessier   +6 more
openaire   +2 more sources

Selective fortification of lysinoalanine, fructoselysine and Nε-carboxymethyllysine in casein model systems

Nahrung/Food, 2001
In the present study, a promising strategy to study nutritional effects of selected chemical reaction products formed in heat treated protein containing foods is addressed. In due course, a selective fortification of different marker compounds for lysine damage in casein-sugar mixtures was performed to provide model systems being applicable to ...
V, Faist, C, Müller, S, Drusch, H F, Erbersdobler   +3 more
openaire   +2 more sources

Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia

Food and Chemical Toxicology, 2013
Hyperglycemia is associated with advanced glycation end products (AGEs). Recently, AGEs were found to cause pancreatic damage, oxidative stress, and hyperglycemia through the AGE receptor. Carboxymethyllysine (CML) is an AGE but whether it induces pancreatic dysfunction remains unclear.
Bao-Hong, Lee, Chia-Chen, Lee, Yu-Hsiang, Cheng, Wen-Chang, Chang, Wei-Hsuan, Hsu, She-Ching, Wu   +5 more
openaire   +2 more sources

Production and Characterization of Antibodies against Carboxymethyllysine-modified Proteins

2005
Summary Carboxymethyllysine (CML) is the major oxidation product of fructose-lysine which results from the reaction of glucose with the e-amino group of free or protein-bound lysine. To develop a quantitative assay for the estimation of the CML content of proteins and for possible immunohistochemical studies, CML antibodies were raised in rabbits ...
Klaus E. Gempel, Eva M. Wagner, Erwin D. Schleicher   +2 more
openaire   +1 more source

Mapping the glycoxidation product N^ε‐carboxymethyllysine in the milk proteome

PROTEOMICS, 2011
AbstractMilk processing leads to severe protein damage caused by the formation of nonenzymatic posttranslational modifications (nePTMs), such as glycation and glycoxidation. As a result, the technological and nutritional function of milk proteins can be critically altered.
Bianca, Meyer, Dima, Al-Diab, Gregor, Vollmer, Monika, Pischetsrieder   +3 more
openaire   +2 more sources

[Experiments with sausage meat on the formation of N epsilon-carboxymethyllysine].

Zeitschrift fur Lebensmittel-Untersuchung und -Forschung, 1995
In model experiments the influence of ingredients normally used for sausage production to a meat homogenate on the formation of N epsilon-carboxymethyllysine (CML) was investigated. The formation of CML is obviously more promoted from the reaction of ascorbate with lysine than from that of glucose with lysine.
J, Hartkopf, H F, Erbersdobler
openaire   +1 more source

Formation of N ɛ -Carboxymethyllysine from Different Sugars and Glyoxal

2005
Summary Equimolar (0.5 M each) aqueous solutions either of lysine monohydrochloride and selected reducing sugars or glyoxal, and a solid mixture containing casein, 10% reducing sugars and 10% distilled water received heat treatment at 98°C; the glyoxal system also received heat treatment at 40°C.
Axel Ruttkat, Helmut F. Erbersdobler
openaire   +1 more source

Nϵ-carboxymethyllysine and neurofibrillary tangles

Neuroscience Letters, 1996
Takemi Kimura, Seikoh Horiuchi
openaire   +1 more source

[Model experiments of the formation of N epsilon-carboxymethyllysine in food products].

Zeitschrift fur Lebensmittel-Untersuchung und -Forschung, 1994
In model experiments with equimolar mixtures of lysinemonohydrochloride and glucose [88% (w/v) water content, 100 degrees C heating temperature] the influence of several conditions (hydrolysis, pH) and ingredients (iron, phosphate, and nitrite) on the formation of N epsilon-carboxymethyllysine (CML) were evaluated.
J, Hartkopf, H F, Erbersdobler
openaire   +1 more source