Association between carotid diameter and the advanced glycation endproduct Nε-Carboxymethyllysine (CML) [PDF]
Cardiovascular Diabetology, 2009 Background Nε-Carboxymethyllysine (CML) is the major non-cross linking advanced glycation end product (AGE). CML is elevated in diabetic patients and apparent in atherosclerotic lesions.
Kouznetsova Tatiana +8 more
doaj +7 more sources
Effect of Nɛ-carboxymethyllysine on oxidative stress and the glutathione system in beta cells
Toxicology Reports, 2014 One of the pathways involved in the pathogenesis of diabetic complications is the formation of excessive levels of advanced glycation end (AGE) products. Nɛ-carboxymethyllysine (CML) is one of the best-characterized AGEs.
Daniëlle M.P.H.J. Boesten +4 more
doaj +5 more sources
Association between enteral carboxymethyllysine intake and daily glycemic variability in critically ill adults: A retrospective cohort study. [PDF]
JPEN J Parenter Enteral NutrAbstract Background Advanced glycation end‐products (AGEs) can enter patients' circulation through exogenous sources, such as enteral nutrition formulae. Circulating AGEs, specifically carboxymethyllysine, can promote insulin resistance and activation of pro‐inflammatory pathways leading to oxidative stress, cell death, and organ failure.
Doola R +6 more
europepmc +4 more sources
Expedient Synthesis of Peptides Containing N ε-Carboxymethyllysine [PDF]
Synlett, 2014 Accumulation of advanced glycation endproducts (AGEs) is responsible for the development and progress of diabetes- and age-related complications. Synthesis of specific chemical probes is key for the detailed understanding of biochemical properties of AGEs and their precise roles in the progression of disease. We herein report the expedient synthesis of
Kamalov, Meder +4 more
openaire +5 more sources
A novel monoclonal antibody targeting carboxymethyllysine, an advanced glycation end product in atherosclerosis and pancreatic cancer. [PDF]
PLoS ONE, 2018 Advanced glycation end products are formed by non-enzymatic reactions between proteins and carbohydrates, causing irreversible lysine and arginine alterations that severely affect protein structure and function.
Ulrika Wendel +9 more
doaj +3 more sources
Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation [PDF]
Nature Communications, 2021 Accumulation of advanced glycation end products such as carboxymethyllysine (CML) has been associated with aging but their molecular roles are largely unclear.
Simone Di Sanzo +13 more
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Nε-carboxymethyllysine in nutritional milk formulas for infants
Food Chemistry, 2019 Production of infant formulas involves high temperature processing for microbiological safety. However, heat processes generate Advanced Glycation End-products (AGEs), including Nε-carboxymethyllysine (CML) formed between lysine and lactose. Formulas manufactured from cow or goat milk, with or without whey adjustment, or hydrolysates of cow whey ...
Elizabeth Carpenter +1 more
exaly +3 more sources
Simultaneous analysis of lysine, Nɛ-carboxymethyllysine and lysinoalanine from proteins
Journal of Chromatography B, 2007 Protein quality was assayed by simultaneous measurement of lysine (Lys), carboxymethyllysine (CML) and lysinoalanine (LAL). GC-FID analysis of N-tert-butyl dimethylsilyl (tBDMSi) derivatives of these amino acids was undertaken. tBDMSi derivates were separated on a CP-SIL 5CB commercially fused silica capillary column (25 m x 0.25 mm i.d., 0.25 microm ...
Bosch, Lourdes +5 more
openaire +4 more sources
Cysteine Mediated Formation of N-ε -Carboxymethyllysine (CML) on Proteins [PDF]
Czech Journal of Food Sciences, 2009 The reaction of glyoxal with nucleophilic amino acids was monitored for β-casein as well as β-lactoglobulin. As predicted from previous experiments with hippuryl amino acids, a measurable decrease of arginine can be found in the thiol-free β-casein ...
U. Schwarzenbolz, T. Henle
doaj +2 more sources
Molecules, 2019 The inhibitory effects of baijiu vinasse extract and its phenolic acid compounds on the Nε-carboxymethyllysine (CML) formation from dairy food were investigated.
Yuzhen Wang +6 more
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