Results 41 to 50 of about 1,999 (189)

How Can Diet Affect the Accumulation of Advanced Glycation End-Products in the Human Body?

Foods, 2016
The accumulation of advanced glycation end products (AGEs) is associated with the complications of diabetes, kidney disease, metabolic disorders and degenerative diseases. It is recognized that the pool of glycation products found in the human body comes
Axel Guilbaud, Celine Niquet-Leridon, Eric Boulanger, Frederic J. Tessier   +3 more
doaj   +1 more source

Heat-induced formation of advanced glycation end-products in ground pork as affected by the addition of acetic acid or citric acid and the storage duration prior to the heat treatments

Food Chemistry: X, 2022
The heat-induced (121 °C, 10 or 30 min) formation of two potentially hazardous advanced glycation end-products (AGEs), protein-bound Nɛ-carboxymethyllysine (CML) and Nɛ-carboxyethyllysine (CEL), in pork as affected by citric or acetic acid (0.5, 1 g/100 ...
Hui Lin, Keqiang Lai, Juanjuan Zhang, Faxiang Wang, Yongle Liu, Barbara A Rasco, Yiqun Huang   +6 more
doaj   +1 more source

Copper(II)-complexation by non enzymatically glycated peptides

Czech Journal of Food Sciences, 2004
The purpose of our work was to examine the metal binding abilities of selected peptide bound Maillard reaction products (MRPs). The Nα-hippuryl-protected MRPs Nε-fructoselysine and Nε-carboxymethyllysine were synthesised and measurement of stability ...
S. T Seifert, R. Krause, K. Gloe, T. Henle   +3 more
doaj   +1 more source

Review of the Characteristics of Food-Derived and Endogenous Nε-Carboxymethyllysine

Journal of Food Protection, 2013
Ne-Carboxymethyllysine (CML), a representative of advanced glycation end products (AGEs), is commonly found in food and is considered a potential hazard to human health. Food scientists have begun to investigate the formation of CML in food processes. As the understanding of CML is mainly based on that of endogenous CML from the fields of biology and ...
Lipeng, Han, Lin, Li, Bing, Li, Di, Zhao, Yuting, Li, Zhenbo, Xu, Guoqin, Liu   +6 more
openaire   +2 more sources

Mapping glycation and glycoxidation sites in collagen I of human cortical bone

BBA Advances, 2023
Accumulation of advanced glycation end products (AGEs), particularly in long-lived extracellular matrix proteins, has been implicated in pathogenesis of diabetic complications and in aging.
Paul Voziyan, Sasidhar Uppuganti, Micheal Leser, Kristie L. Rose, Jeffry S. Nyman   +4 more
doaj   +1 more source

3-Deoxyglucosone: a potential glycating agent accountable for structural alteration in H3 histone protein through generation of different AGEs. [PDF]

PLoS ONE, 2015
Advanced glycation end-products (AGEs) are heterogeneous group of compounds, known to be implicated in diabetic complications. One of the consequences of the Maillard reaction is attributed to the production of reactive intermediate products such as α ...
Jalaluddin M Ashraf, Saheem Ahmad, Gulam Rabbani, Qambar Hasan, Arif Tasleem Jan, Eun Ju Lee, Rizwan Hasan Khan, Khursheed Alam, Inho Choi   +8 more
doaj   +1 more source

Plasma Protein Pentosidine and Carboxymethyllysine, Biomarkers for Age-related Macular Degeneration [PDF]

Molecular & Cellular Proteomics, 2009
Age-related macular degeneration (AMD) causes severe vision loss in the elderly; early identification of AMD risk could help slow or prevent disease progression. Toward the discovery of AMD biomarkers, we quantified plasma protein N(epsilon)-carboxymethyllysine (CML) and pentosidine from 58 AMD and 32 control donors.
Ni, Jiaqian, Yuan, Xianglin, Gu, Jiayin, Yue, Xiuzhen, Gu, Xiaorong, Nagaraj, Ram H., Crabb, John W.   +6 more
openaire   +2 more sources

Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes [PDF]

, 2012
Objective To determine the role of markers of plasma protein damage by glycation, oxidation and nitration in microalbuminuria onset or subsequent decline of glomerular filtration rate (termed “early GFR decline”) in patients with type 1 diabetes ...
Weston Andrew, Rabbani, N, Warram, James, Paul Thornalley, Perkins, BA, Naila Rabbani, Monika Niewczas, Thornalley, P, Thornalley, Paul J., Krolewski, AS, Rabbani, Naila, Adaikalakoteswari Antonysunil, Perkins Bruce A., Bruce A Perkins, Perkins, Bruce A., Weston, A, Thornalley Paul, Rabbani Naila, Krolewski, Andrzej S., Niewczas, M, Antonysunil Adaikalakoteswari, Adaikalakoteswari, A, Weston, Andrew J., Linda H Ficociello, Ficociello, LH, Ficociello Linda H., James Warram, Andrzej S Krolewski, Niewczas Monika, Warram, J, Andrew Weston, Antonysunil, Adaikalakoteswari, Warram James, Krolewski Andrzej S., Niewczas, Monika, Ficociello, Linda H.   +35 more
core   +1 more source

Phlorotannins Remarkably Suppress the Formation of -(Carboxymethyl)lysine in a Collagen-Glyoxal Environment

Natural Product Communications, 2020
N ε -(Carboxymethyl)lysine (CML), which is formed by the glycation of collagen, is a skin-accumulating advanced glycation end product and has been shown to be deeply involved in diabetic osteopenia and skin aging.
Naoki Murata, Mitsuhiro Azuma, Kousuke Yamauchi, Hideo Miyake, Reiji Tanaka, Toshiyuki Shibata   +5 more
doaj   +1 more source

Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N⁶-carboxymethyllysine

, 2022
Microglial function declines during aging. The interaction of microglia with the gut microbiota has been well characterized during development and adulthood but not in aging.
Maron, F., Ganal-Vonarburg, Stephanie, MacPherson, Andrew J. S., Ganal-Vonarburg, S., Blank, Thomas, Nent, E., Szalay, A., Mossad, O., Mayer, M., Prinz, Marco, Szalay, Antal, Macpherson, A., Blank, T., Mocayar Maron, Feres Jose, Batut, B., Mezö, Charlotte, Macpherson, Andrew, Backofen, R., Dokalis, Nikolaos, Nent, Elisa, Erny, D., Ganal-Vonarburg, Stephanie C, Prinz, M., de Agüero, M., Buescher, Joerg, Ganal-Vonarburg, Stephanie Christine, Batut, Bérénice, Gomez de Agüero, Mercedes, Buescher, Joerg M., Erny, Daniel, Maron, Feres José Mocayar, Buescher, Joerg M, Mezö, C., Nabavi, L., Backofen, Rolf, Lämmermann, Tim, Macpherson, Andrew J, Dokalis, N., Büscher, J., Lämmermann, T., Yilmaz, Bahtiyar, Mayer, Melanie, Nabavi, Lara Susann, de Agüero, Mercedes Gomez, Mossad, Omar, Yilmaz, B.   +45 more
core   +1 more source