Results 61 to 70 of about 1,999 (189)

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

Advanced Science, Volume 13, Issue 24, 27 April 2026.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin, Karthikeyan Narayanan, Deepak Vashishth   +2 more
wiley   +1 more source

Lactococcus lactis KF140 Reduces Dietary Absorption of Nε - (Carboxymethyl)lysine in Rats and Humans via β-Galactosidase Activity

Frontiers in Nutrition, 2022
Background and AimsExcessive intake of advanced glycation end products (AGEs), which are formed in foods cooked at high temperatures for long periods of time, has negative health effects, such as inflammatory responses and oxidative stress.
Ho-Young Park, Hye-Bin Lee, So-Young Lee, Mi-Jin Oh, Sang Keun Ha, Eunju Do, Hyun Hee L. Lee, Jinyoung Hur, Kwang-Won Lee, Mi-Hyun Nam, Myoung Gyu Park, Yoonsook Kim   +11 more
doaj   +1 more source

Advanced Glycation End-Products (AGEs) and Their Soluble Receptor (sRAGE) in Women Suffering from Systemic Lupus Erythematosus (SLE)

Cells, 2021
Systemic lupus erythematosus (SLE) is characterized by abnormal action of the immune system and a state of chronic inflammation. The disease can cause life-threatening complications.
Agnieszka Nowak, Brygida Przywara-Chowaniec, Aleksandra Damasiewicz-Bodzek, Dominika Blachut, Ewa Nowalany-Kozielska, Krystyna Tyrpień-Golder   +5 more
doaj   +1 more source

Microbial Transformation of Oxidized Methionine and Tyrosine Derivatives: Insights From Food‐ and Gut‐Associated Bacteria

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Protein oxidation yields numerous modified amino acids in food, yet the microbial fate of these compounds remains largely uncharacterized. We challenged several representative food‐ and gut‐associated bacteria with oxidized methionine and tyrosine derivatives.
Kim Ina Behringer, Erica Flora Aveta, Tess Brewer, Jürgen Lassak, Michael Hellwig, Prisca-Maryla Henheik   +5 more
wiley   +1 more source

Urinary metabolomic profiling in 22q11.2 deletion syndrome reveals microbial and mitochondrial signatures related to autism and psychosis risk

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Aim 22q11.2 deletion syndrome (22qDS) is the most common copy‐number‐variation disorder, associated with multi‐organ anomalies and elevated risk for schizophrenia and other neuropsychiatric conditions. Previous metabolomic studies have used blood samples, implicating mitochondrial dysfunction and amino acid imbalance, but no urinary ...
Takuto Minami, Tempei Ikegame, Miho Tanaka, Eureka Kumagai, Akiko Kanehara, Ryo Morishima, Yousuke Kumakura, Noriko Okochi, Junko Hamada, Tomoko Ogawa, Hidetaka Tamune, Yukiko Kano, Seiichiro Jinde, Kiyoto Kasai   +13 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Influence of Nonenzymatic Browning Reactions on the Digestibility and Gut Microbiota Fermentation of Starch and Protein

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 6, November 2025.
ABSTRACT Cooking has dramatic effects on the digestion and fermentation of food components. The changes that occur to starch and protein during nonenzymatic browning (NEB) have garnered attention due to health concerns. Among these changes, Maillard reaction, caramelization, and oxidation have major effects on starch and protein digestibility, as well ...
Wensheng Ding, Yichen Bai, Devin J. Rose
wiley   +1 more source

Nε-carboxymethyllysine-mediated endoplasmic reticulum stress promotes endothelial cell injury through Nox4/MKP-3 interaction

, 2015
N(ε)-carboxymethyllysine (CML) is an important driver of diabetic vascular complications and endothelial cell dysfunction. However, how CML dictates specific cellular responses and the roles of protein tyrosine phosphatases and ERK phosphorylation remain
Sheu, Meei-Ling, Chen, Wei-Chih, Lee, Wen-Jane, Yang, Tzung-Jie, Yi, Yu-Chiao, Lee, Maw-Rong, Yeh, Hsiang-Yu, Lin, Shih-Yi, Lin, Li-Yun, Liang, Kae-Woei, Tsai, Yi-Ching, Liu, Shing-Hwa, Shen, Chin-Chang, Huey-Herng Sheu, Wayne, Tien, Hsing-Ru   +14 more
core   +2 more sources

Identification of the Carboxymethyllysine Residue in the Advanced Stage of Glycated Human Serum Albumin.

Chemical and Pharmaceutical Bulletin, 1992
As an advanced stage of glycation, glycated human serum albumin (G-HSA; glucose content, 2 mol of 5-hydroxymethylfurfural equivalent/mol of HSA) was incubated at 37 degrees C up to 30 d in 0.2 M phosphate buffer, pH 7.4, with 100 microM Fe3+. G-HSA incubated for 30 d (G-HSA-30(Fe)) was subsequently hydrolyzed at 110 degrees C for 24 h in 6 N HCl.
TAKANASHI, Masaya, SAKURAI, Tamiko, TSUCHIYA, Seishi   +2 more
openaire   +3 more sources

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

The FEBS Journal, Volume 292, Issue 19, Page 5067-5085, October 2025.
Duchenne muscular dystrophy is a severe neuromuscular wasting disease that is caused by a primary defect in dystrophin protein. A targeted mass‐spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy.
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source