Results 71 to 80 of about 1,999 (189)

Type 2 diabetes and depression via microvascular dysfunction, neurodegeneration, inflammation, advanced glycation end products (AGEs), and arterial stiffness

Diabetes, Obesity and Metabolism, Volume 27, Issue 9, Page 4847-4858, September 2025.
Abstract Aims Type 2 diabetes increases the risk of depression, but the mechanisms underlying this association are incompletely understood. We investigated whether microvascular dysfunction, neurodegeneration, low‐grade inflammation, advanced glycation end products (AGEs) and arterial stiffness, pathologies that are more common in diabetes, explain, or
Indra L. M. Steens, Miranda T. Schram, Alfons J. H. M. Houben, Tos T. J. M. Berendschot, Jacobus F. A. Jansen, Walter H. Backes, Annemarie Koster, Hans Bosma, Simone J. P. M. Eussen, Bastiaan E. de Galan, Thomas T. van Sloten   +10 more
wiley   +1 more source

Rosiglitazone modulates the behaviors of diabetic host‐derived fibroblasts in a carboxymethyllysine‐modified collagen model

, 2012
Utilizing a three‐dimensional in vitro glycated collagen model, we evaluated the therapeutic effects of a peroxisome proliferator‐activated receptor‐γ ligand, rosiglitazone, and its potential as a topical treatment of diabetic chronic wounds ...
Chen, Weiliam, Pastar, Irena, Liao, Huijuan   +2 more
core   +1 more source

Effects of Formulation and Baking Conditions on Neo-formed Contaminants in Model Cookies

Czech Journal of Food Sciences, 2009
This work aimed at studying the influence of baking temperature and formulation on the formation of undesirable Maillard compounds called neoformed contaminants (NFC) in a model cookie system.
M. Courel, L. Ait-Ameur, E. Capuano, V. Fogliano, F. J. Morales, F. Courtois, I. Birlouez-Aragon   +6 more
doaj   +1 more source

Association Between Serum Advanced Glycation End Products and Cardiovascular‐Kidney‐Metabolic (CKM) Syndrome: A 3‐Year Longitudinal Cohort Study (2019–2022)

Journal of Diabetes, Volume 17, Issue 8, August 2025.
Our study reveals that elevated serum Advanced glycation end products (AGEs) are significantly associated with both the severity and progression of cardiovascular‐kidney‐metabolic (CKM) syndrome. The findings demonstrate dose‐dependent severity associations (adjusted OR = 1.92, Q4 vs. Q1) and predict 3‐year disease worsening (high‐risk vs. low‐risk: OR 
Hui Zhao, Ze‐wen Zhang, Tao Luo, Dilihumaer Aili, Wen‐huan Ding, Yuan‐yuan Li, Yuan‐sheng Gu, Shulipan Aslibek, Jing‐jing He, Wen‐hui Yu, Run‐ze Ma, Anaer Gaoshao, Ting‐ting Qiao, Guo‐zhen Zhang, Henry S. Lynn, Mu‐long Du, Jiang‐hong Dai   +16 more
wiley   +1 more source

N(epsilon)-carboxymethyllysine-modified proteins are unable to bind to RAGE and activate an inflammatory response

, 2008
Advanced glycation endproducts (AGEs) containing carboxymethyllysine (CML) modifications are generally thought to be ligands of the receptor for AGEs, RAGEs. It has been argued that this results in the activation of pro-inflammatory pathways and diseases.
Newell, J, Junod, S, Leclerc, E, Maurer, S, Adolfsson, O, Buetler, T M, Baumeyer, A, Piguet, D, Richoz, J, Heizmann, C W, Foata, F, Latado, H, Delatour, T, Parisod, V   +13 more
core   +1 more source

Carbonylation of hair proteins: A robust biomarker of molecular and structural oxidative damage in hair fibres

International Journal of Cosmetic Science, Volume 47, Issue 4, Page 604-625, August 2025.
The protein carbonylation biomarker is validated as reliable molecular damage marker to monitor hair oxidative damage (chemical and photo oxidation). It is slightly more sensitive than the cysteic acid in the case of photochemical oxidation and allows to geolocate qualitatively and quantitatively the oxidation within the hair fibre substructures ...
Camille Grosjacques, Sabine Babiel, Jing Hodes, Anais Bobier, Andrea Cavagnino, Martin Baraibar   +5 more
wiley   +1 more source

Carboxymethyl-lysine is a Prominent Target of Circulating IgA in IgA Nephropathy

Kidney International Reports
Introduction: IgA nephropathy (IgAN), the most prevalent glomerular disease worldwide, carries a significant risk of kidney failure. Its pathogenesis involves the presence of elevated levels of IgA and galactose-deficient IgA (Gd-IgA), deposition of ...
Sara Alibrandi, Talita Aguiar, Mattea Ausmeier, Paolo Molinari, Enrico Fiaccadori, Umberto Maggiore, Nicholas Chun, Maria Lanau, Mario Perez-Arnedo, Joaquin Manrique, Paolo Cravedi, Emmanuel Zorn   +11 more
doaj   +1 more source

N-carboxymethyllysine as a biomarker for coronary artery disease and age-related macular degeneration

Medicina, 2016
Background and objective: An association between coronary artery disease (CAD) and age-related macular degeneration (ARMD) has long been postulated, but exact mechanisms remain unclear. The global prevalence of CAD and ARMD increases and early biomarkers
Daiva Stanislovaitienė, Dalia Žaliūnienė, Rasa Steponavičiūtė, Reda Žemaitienė, Olivija Gustienė, Remigijus Žaliūnas   +5 more
doaj   +1 more source

Exploring the Effects of Plant‐Based Ingredients and Phytochemicals on the Formation of Advanced Glycation End Products in Bakery Products: A Systematic Review

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
This systematic review highlights the potential activity of plant‐based ingredients and phytochemicals to reduce the formation of AGEs and α‐dicarbonyl compounds in bakery products. The examined studies demonstrated that various phytochemicals, including flavonoids, phenolic acids, stilbenes, and other polyphenols, as well as various plant extracts and
Busra Turan‐Demirci, Buket Gonen‐Colak, Zehra Buyuktuncer   +2 more
wiley   +1 more source

Serum carboxymethyllysine concentrations are reduced in diabetic men with abdominal aortic aneurysms: health in men study

, 2009
Objective: Abdominal aortic aneurysms (AAAs) share common risk factors with atherosclerosis, except for diabetes which appears protective. The reason for this is unknown.
Davis, Timothy M.E., Davis, Timothy M. E., Golledge, Jonathan, Davis, Wendy A., Coughlan, Melinda T., Forbes, Josephine M., Norman, Paul E.   +6 more
core   +1 more source