Results 101 to 110 of about 93,784 (226)

Selective Cytotoxicity of Carboxypeptidase-activated Methotrexate ex-Peptides

open access: yesPteridines, 1989
Methotrexate ex-pep tides (derivatives in which an amino acid is linked covalently to the ex-carboxyl of the glutamate residue on the parent drug) can be hydrolyzed by specific carboxypeptidases to yield free Methotrexate (MTX) and the corresponding ...
Vitols Karin S.   +3 more
doaj   +1 more source

Algorithms in Allergy: Hereditary Angioedema

open access: yes
Allergy, EarlyView.
Konrad Bork   +3 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, Volume 600, Issue 5, Page 631-643, March 2026.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

open access: yesAdvanced Science, Volume 13, Issue 14, 9 March 2026.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang   +12 more
wiley   +1 more source

A comparative study of an aminopeptidase from lactic acid bacteria: a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

open access: yes, 1992
Aminopeptidase enzymes from the proteolytic systems of S.salivarius subsp.thermophilus Lactococcus lactis subsp.cremoris and Lactococcus lactis subsp.lactis have been investigated.
Midwinter, Robyn Gillian
core  

An Overview of Polyphenols and Color Chemistry in Cocoa

open access: yesAgriFood: Journal of Agricultural Products for Food, Volume 2, Issue 1, Page 80-95, March 2026.
Cocoa polyphenols have been traditionally known for their beneficial properties in human health. However, less is known about their other impacts on cocoa processing. This review highlights current discoveries in the role of polyphenols in the formation of color in cocoa.
Jasmeet Kaur Khanijou, Mario Wibowo
wiley   +1 more source

An ANN‐Driven Fermenter System for Bacterial Health Assessment During Cocoa Bean Fermentation

open access: yesEngineering Reports, Volume 8, Issue 3, March 2026.
The ANN model comprises an input layer (pH, cocoa temperature, fermenter temperature, and humidity) and one output node (bean health prediction). It features four hidden layers (20 nodes/layer), sigmoid activation, and MSE loss, optimized with a 0.01 learning rate, batch size 15, and 100 epochs.
Khaithrileya Arethaputri   +2 more
wiley   +1 more source

Role of carboxypeptidases to the free amino acid composition, methylpyrazine formation and sensory characteristic of under- fermented cocoa beans [PDF]

open access: yes, 2010
The role of carboxypeptidases B (from porcine) and Y (from baker's yeast), applied to under-fermented cocoa beans, on the formation of cocoa-specific aroma precursors, the aroma and sensory quality after roasting was investigated.
Bakar, Jamilah   +4 more
core  

Camel Milk as a Functional Food: Nutritional Composition, Health‐Promoting Benefits, and Safety Considerations

open access: yesFood Science &Nutrition, Volume 14, Issue 3, March 2026.
Camel milk contains low lactose, unique casein proteins, high vitamin contents, and diverse bioactive compounds that support metabolic health, immune function, organ protection, gut health, physical development, and brain function. Its benefits are mediated through antioxidant, anti‐inflammatory, insulin‐like effects, and immunomodulatory mechanisms ...
Gudisa Bereda   +2 more
wiley   +1 more source

Leonurine: A Multifaceted Bioactive Alkaloid—From Pharmacological Mechanisms to Clinical Translation: A Narrative Review

open access: yesHealth Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and vasoprotective effects. This review aims to provide a comprehensive overview of LEO's pharmacokinetics, pharmacological mechanisms ...
Zhouyue Gu
wiley   +1 more source

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