Results 91 to 100 of about 1,077,378 (364)

Multiple myeloma presenting as CEA-producing rectal cancer

Rare Tumors, 2010
We report the case of a 57-year old patient with multiple myeloma, characterized by extramedullary involvement of the rectum at presentation. Malignant plasma cells were found to produce carcinoembryonic antigen (CEA), a tumor antigen more commonly ...
Giampaolo Talamo
doaj   +1 more source

Sensitivity of Carcinoembryonic Antigen Level in Head and Neck, Breast, Lung, Genitourinary, Gastrointestinal Carcinoma

Pakistan Armed Forces Medical Journal, 2023
Objective: To determine the Carcinoembryonic Antigen Levels among patients with epithelial carcinoma presenting at a tertiary care hospital. Study Design: Prospective longitudinal study. Place and Duration of Study: Department of Medical Oncology,
Madiha Hashmi, Ghulam Haider, Muhammad Danish, Razia Irhsad, Anusha Hassan, Salahuddin Khan   +5 more
doaj   +1 more source

Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer. [PDF]

, 2017
BackgroundT cells engineered to express chimeric antigen receptors (CARs) have established efficacy in the treatment of B-cell malignancies, but their relevance in solid tumors remains undefined.
A Molinolo, A Stasi Di, A Thor, B Fisher, BA Irving, BL Levine, C Romeo, CC Kloss, CY Wu, D Moritz, DL Porter, DW Lee, F Guadagni, HM Finney, I Blanco, I Stancovski, J Scholler, JD Wolchok, JL Murray, JN Kochenderfer, JW Greiner, KD Griffith, L Naldini, M Hegde, M Kalos, ME Dudley, MH Finer, MH Kershaw, ML Davila, MR Lander, N Gonzales, NP Restifo, P Hwu, RA Morgan, RE Walker, RF Meredith, RP McGuinness, RT Mitsuyasu, S Guedan, SD Patel, SG Deeks, SL Maude, SV Kashmiri   +42 more
core   +1 more source

The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity

Cancer Immunology and Immunotherapy, 2017
The primary aim of this clinical trial was to determine the feasibility of delivering first-generation CAR T cell therapy to patients with advanced, CEACAM5+ malignancy.
F. Thistlethwaite, D. Gilham, R. Guest, D. Rothwell, M. Pillai, D. Burt, A. Byatte, N. Kirillova, J. Valle, Sur Sharma, K. Chester, N. Westwood, S. Halford, S. Nabarro, S. Wan, E. Austin, R. Hawkins   +16 more
semanticscholar   +1 more source

Terahertz Metamaterial Sensors: Design Theory, Optimization Approach, and Advancements in Biosensing Applications

Advanced Materials Technologies, EarlyView.
This review provides an in‐depth overview of the design principles and optimization strategies for terahertz (THz) metamaterials (MMs) sensors based on the dielectric perturbation theory. Various structures and methods are explored to enhance sensor performance, focusing on improving sensitivity and Q‐factor.
Lei Cao, Shanshan Jia, Fanqi Meng, Merle Richter, Yannik Loth, Anna Katharina Wigger, Chenglin Yang, Liuyang Zhang, Peter Haring Bolívar, Hartmut G. Roskos   +9 more
wiley   +1 more source

Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses [PDF]

, 2015
Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and re-infect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA) and amino acid substitutions at exposed epitope sites in HA mediate loss of recognition by antibodies.
arxiv   +1 more source

Computational model for tumor response to adoptive cell transfer therapy [PDF]

arXiv, 2022
One of the barriers to the development of effective adoptive cell transfer therapies (ACT), specifically for genetically engineered T-cell receptors (TCRs), and chimeric antigen receptor (CAR) T-cells, is target antigen heterogeneity. It is thought that intratumor heterogeneity is one of the leading determinants of therapeutic resistance and treatment ...
arxiv  

The Roles of Carcinoembryonic Antigen in Liver Metastasis and Therapeutic Approaches

Gastroenterology Research and Practice, 2017
Metastasis is a highly complicated and sequential process in which primary cancer spreads to secondary organic sites. Liver is a well-known metastatic organ from colorectal cancer.
J. Lee, Seong-Wook Lee
semanticscholar   +1 more source

Optical Microfiber Biomedical Sensors: Classification, Applications, and Future Perspectives

Advanced Sensor Research, EarlyView.
This review delves deeply into the various types of optical microfiber biosensors, grounded firmly in their fundamental principles, and underscores their indispensable roles in pushing forward biomedical advancements. It examines the latest advancements, challenges faced by these biosensors in practical applications, future directions, breakthroughs ...
Lili Liang, Fei Xie, Li Jin, Bowen Yang, Li‐Peng Sun, Bai‐Ou Guan   +5 more
wiley   +1 more source

Sequence-Based Nanobody-Antigen Binding Prediction [PDF]

arXiv, 2023
Nanobodies (Nb) are monomeric heavy-chain fragments derived from heavy-chain only antibodies naturally found in Camelids and Sharks. Their considerably small size (~3-4 nm; 13 kDa) and favorable biophysical properties make them attractive targets for recombinant production.
arxiv