Results 101 to 110 of about 84,483 (336)
Advanced Science, EarlyView.Plasmonic molecular entrapment (PME) is label‐free detection and quantification method for DNA methylation. This technique provides direct hotspot site generation around target analytes, overcoming mismatch geometrical properties. The PME demonstrates superior SERS performance and quantification capability, offering promising potential for epigenetic ...
Muhammad Shalahuddin Al Ja'farawy +9 more
wiley +1 more source
Dynamics-based peptide-MHC binding optimization by a convolutional variational autoencoder: a use-case model for CASTELO [PDF]
arXiv, 2020 An unsolved challenge in the development of antigen specific immunotherapies is determining the optimal antigens to target. Comprehension of antigen-MHC binding is paramount towards achieving this goal. Here, we present CASTELO, a combined machine learning-molecular dynamics (ML-MD) approach to design novel antigens of increased MHC binding affinity ...
arxiv
Chromosomal Localization of the Carcinoembryonic Antigen Gene Family and Differential Expression in Various Tumors [PDF]
, 1988 Carcinoembryonic antigen (CEA) is a glycoprotein which is important as a tumor marker for a number of human cancers. It is a member of a gene family comprising about 10 closely related genes.
Fiebig, Heinz-Herbert +8 more
core +1 more source
A Wearable In‐Pad Diagnostic for the Detection of Disease Biomarkers in Menstruation Blood
Advanced Science, EarlyView.MenstruAI integrates a paper‐based biosensor into sanitary pads to detect biomarkers in menstrual blood, enabling accessible, lab‐free diagnostics health. The platform supports early disease detection, especially in underserved communities, while challenging menstrual stigma and opening pathways for scalable, inclusive, and sustainable population ...
Lucas Dosnon +3 more
wiley +1 more source
Personalized Risk Assessment in Never, Light, and Heavy Smokers in a prospective cohort in Taiwan. [PDF]
, 2016 The objective of this study was to develop markedly improved risk prediction models for lung cancer using a prospective cohort of 395,875 participants in Taiwan.
Chow, Wong-Ho +14 more
core +1 more source
AGING MEDICINE, EarlyView.ABSTRACT Objective The incidence of intraductal papillary mucinous neoplasm (IPMN) is rising among elderly patients. This study aims to investigate the clinical features of IPMN in elderly patients (≥ 60 years), analyze risk factors for high‐grade dysplasia (HGD) and invasive cancer (IC), and provide treatment recommendations for elderly patients with ...
Tianhan Sun +8 more
wiley +1 more source
Discrimination of Membrane Antigen Affinity by B cells Requires Dominance of Kinetic Proofreading over Serial Triggering [PDF]
arXiv, 2010 B cells receptor (BCR) signaling in response to membrane-bound antigen increases with antigen affinity, a process known as affinity discrimination. We use computational modeling to show that B cell affinity discrimination requires that kinetic proofreading predominate over serial engagement.
arxiv
A Novel Magnetoelastic Immunosensor for Ultrasensitively Detecting Carcinoembryonic Antigen
Nanoscale Research Letters, 2018 A novel wireless immunosensor is developed for the ultra-sensitive detection of carcinoembryonic antigen. The optimum dimension of the microchips, as magnetoelastic sensitive units, was evaluated by simulation and experiments.
Yixia Zhang +4 more
doaj +1 more source
Annals of Gastroenterological Surgery, EarlyView.This retrospective study evaluates the prognostic factors in patients undergoing curative hepatic resection for rectal cancer liver metastases. It identifies lateral lymph node metastasis and perineural invasion as significant prognostic factors. Moreover, patients with these factors required nonsurgical treatment in the early postoperative period ...
Tomofumi Uotani +9 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.Preoperative GPS2 is an independent poor prognostic factor in patients with colorectal cancer and synchronous peritoneal metastases, and surgical resection does not improve prognosis in patients with GPS2. Preoperative GPSs may be used as indicators for surgical resection of synchronous peritoneal metastases.
Kosuke Fujimoto +31 more
wiley +1 more source