Results 1 to 10 of about 461 (113)

IL6 and BCL3 Expression Are Potential Biomarkers in Esophageal Squamous Cell Carcinoma [PDF]

Frontiers in Oncology, 2021
Esophageal squamous cell carcinoma (ESCC) ranks among the most lethal tumors worldwide, as a consequence of late detection and poor treatment response, evidencing the need for diagnosis anticipation and new therapeutic targets. First, we investigated the
Sheila Coelho Soares-Lima, Isabela Martins Gonzaga, Diego Camuzi, Pedro Nicolau-Neto, Raissa Vieira da Silva, Simone Guaraldi, Simone Guaraldi, Maria Aparecida Ferreira, Hector Hernandez-Vargas, Zdenko Herceg, Luis Felipe Ribeiro Pinto   +10 more
doaj   +2 more sources

Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms. [PDF]

Hemasphere, 2021
Mutations in the calreticulin (CALR) gene are seen in about 30% of essential thrombocythemia and primary myelofibrosis patients. To address the contribution of the human CALR mutants to the pathogenesis of myeloproliferative neoplasms (MPNs) in an endogenous context, we modeled the CALRdel52 and CALRins5 mutants by induced pluripotent stem cell (iPSC ...
Secardin L, Gomez Limia C, da Silva-Benedito S, Lordier L, El-Khoury M, Marty C, Ianotto JC, Raslova H, Constantinescu SN, Bonamino MH, Vainchenker W, Monte-Mor B, Di Stefano A, Plo I.   +13 more
europepmc   +2 more sources

HLA-B Serine 116 Confers Protection Against Severe COVID-19 in a Cohort From Rio de Janeiro, Brazil. [PDF]

HLA
ABSTRACT COVID‐19 is a respiratory disease caused by SARS‐CoV‐2, in which severe outcomes are primarily driven by an exacerbated immune response. The HLA region has been extensively investigated in COVID‐19 due to its central role in the immune response, although genetic associations vary across populations.
Pereira MADS, Ferreira SN, Gonçalves CCA, Reis MCD, Zampier CDP, Leitão IC, Lopes MSA, Rossi AD, Soares-Lima SC, Galliez RM, Barroso SPC, Junior ODCF, Tanuri A, Castiñeiras TMPP, Rossi ÁD, Cardoso CC.   +15 more
europepmc   +2 more sources

The Prominent Role of HMGA Proteins in the Early Management of Gastrointestinal Cancers. [PDF]

Biomed Res Int, 2019
GI tumors represent a heterogeneous group of neoplasms concerning their natural history and molecular alterations harbored. Nevertheless, these tumors share very high incidence and mortality rates worldwide and patients’ poor prognosis. Therefore, the identification of specific biomarkers could increase the development of personalized medicine, in ...
Meireles Da Costa N, Ribeiro Pinto LF, Nasciutti LE, Palumbo A.   +3 more
europepmc   +2 more sources

Potential Therapeutic Effects of Underground Parts of Kalanchoe gastonis-bonnieri on Benign Prostatic Hyperplasia. [PDF]

Evid Based Complement Alternat Med, 2019
Benign Prostatic Hyperplasia (BPH) affects mainly older men. It is estimated to affect 50% of 51‐60‐year‐old men and 70% of 61‐70‐year‐old men. BPH is a nonmalignant proliferation of epithelial and stromal cells of the prostate gland regions. Despite the use of conventional pharmacological therapy, herbal medicines are used in BPH therapy, and several ...
Palumbo A, Casanova LM, Corrêa MFP, Da Costa NM, Nasciutti LE, Costa SS.   +5 more
europepmc   +2 more sources

Carcinogênese hormonal e neoplasias hormônio-dependentes [PDF]

Ciência Rural, 2004
As neoplasias hormônio-dependentes podem originar-se de mutações genéticas resultantes da proliferação de células normais ou da multiplicação de células já transformadas por outros carcinógenos.
Alessandra Estrêla da Silva, Rogéria Serakides, Geovanni Dantas Cassali   +2 more
doaj   +1 more source

Carcinogênese Química Cutânea

Revista Brasileira de Cancerologia, 2023
Os progressos técnicos obtidos na primeira metade deste século, facilitando a indução química de tumores cutâneos em diversos animais experimentais, permitiram que se avançasse no estudo dos mecanismos biológicos envolvidos na carcinogênese.
Maria Angélica Guzmán Silva, Jorge S. P. Guimarães   +1 more
doaj   +1 more source

Insights into the Oncogenic, Prognostic, and Immunological Role of BRIP1 in Pan‐Cancer: A Comprehensive Data‐Mining‐Based Study

Journal of Oncology, Volume 2023, Issue 1, 2023., 2023
Background. BRCA1 interacting helicase 1 (BRIP1), an ATP‐dependent DNA helicase which belongs to an Iron‐Sulfur (Fe‐S) helicase cluster family with a DEAH domain, plays a key role in DNA damage and repair, Fanconi anemia, and development of several cancers including breast and ovarian cancer.
Yongru Liu, Xi Wu, Yunlu Feng, Qingwei Jiang, Shengyu Zhang, Qiang Wang, Aiming Yang, Yanqing Liu   +7 more
wiley   +1 more source

CARACTERIZAÇÃO DA HETEROGENEIDADE MOLECULAR E IDENTIFICAÇÃO DE MARCADORES MOLECULARES ASSOCIADOS COM IKZF1PLUS EM LEUCEMIA LINFOBLÁSTICA AGUDA DE CÉLULAS PRECURSORAS-B

Hematology, Transfusion and Cell Therapy, 2023
A leucemia linfoblástica aguda de células precursoras B (LLA-CPB) pode ser classificada pela ocorrência de várias alterações genéticas. O subgrupo IKZF1plus é definido pela coocorrência de IKZF1del e de deleções em CDKN2A, CDKN2B, PAX5 ou na região ...
CB Blunck, CP Poubel, BA Lopes, TC Barbosa, MB Mansur, M Emerenciano   +5 more
doaj   +1 more source

Revisão e atualização sobre carcinogênese química cutânea

Revista Brasileira de Cancerologia, 2023
A pele de camundongo tem uma longa história como modelo experimental vantajoso no estudo da carcinogênese. As informações adquiridas através da indução química de tumores cutâneos indicam que o desenvolvimento neoplásico consiste de múltiplas etapas. As
Maria Angélica Guzmán-Silva
doaj   +1 more source