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Anais da Academia Brasileira de Ciências, 2007 The use of chemical compounds benefits society in a number of ways. Pesticides, for instance, enable foodstuffs to be produced in sufficient quantities to satisfy the needs of millions of people, a condition that has led to an increase in levels of life ...
Paula A. Oliveira +5 more
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What Can Chemical Carcinogenesis Shed Light on the LNT Hypothesis in Radiation Carcinogenesis? [PDF]
Dose-Response, 2019 To protect the public’s health from exposure to physical, chemical, and microbiological agents, it is important that any policy be based on rigorous scientifically based research. The concept of “linear no-threshold” (LNT) has been implemented to provide
James E. Trosko
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Langerhans cells and NK cells cooperate in the inhibition of chemical skin carcinogenesis
OncoImmunology, 2017 Tissue immunosurveillance is an important mechanism to prevent cancer. Skin treatment with the carcinogen 7,12-dimethylbenz(a)anthracene (DMBA), followed by the tumor promoter 12-O-tetra-decanoyl-phorbol-13-acetate (TPA), is an established murine model ...
Daniela Ortner +10 more
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Dose-Response Curves in Chemical Carcinogenesis
Dose-Response, 2004 Extrapolation from studies of chemical carcinogenicity in rodents, at high doses, to humans, at the typically low doses to which we are exposed, has been one of the most controversial issues in toxicology.
William J. Waddell
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Alert-QSAR. Implications for Electrophilic Theory of Chemical Carcinogenesis [PDF]
International Journal of Molecular Sciences, 2011 Ana-Maria Lacrama +2 more
exaly +2 more sources
Toxicological Sciences, 2010 Understanding the relationship of chemicals to carcinogenesis has progressed significantly since the initial observations of Hill and Pott in the 1700's. Distinguishing between DNA-reactive chemicals and those which increase cancer risk by increasing cell proliferation has been a major breakthrough in delineating overall mechanisms. Competing processes
Samuel M, Cohen, Lora L, Arnold
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Environment International, 2022 Benzo[a]pyrene (B[a]P) is a class I carcinogen and hazardous environmental pollutant with genetic toxicity. Understanding the molecular mechanisms underlying genetic deterioration and epigenetic alterations induced by environmental contaminants may ...
Miaoyun Qiu +8 more
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Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells
Molecular Cancer, 2020 Background Lung cancer has high morbidity and mortality worldwide with non-small cell lung cancer (NSCLC) accounting for 85% of the cases. Therapies for lung cancer have relatively poor outcomes and further improvements are required.
Nan Zhang +10 more
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Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1976 The first step in the generation of a malignancy seems to be a transformation in the genetic apparatus of a single cell. The ultimate nature of the cancer which appears is a result of the interaction of that change with the control and regulatory apparatus of the whole animal. It appears that the primary cellular change which may be induced by physical,
openaire +5 more sources
Environment International, 2020 Fine particulate matter (PM2.5) has been verified to augmented the incidence of pneumonia, asthma, pulmonary fibrosis, and other pulmonary diseases. Airway inflammation is the pathological basis of the respiratory system, and understanding the molecular ...
Yangyang Jia +10 more
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