Results 1 to 10 of about 83,835 (249)

Chemical carcinogenesis [PDF]

open access: yesAnais da Academia Brasileira de Ciências, 2007
The use of chemical compounds benefits society in a number of ways. Pesticides, for instance, enable foodstuffs to be produced in sufficient quantities to satisfy the needs of millions of people, a condition that has led to an increase in levels of life expectancy.
Oliveira, Paula A.   +5 more
core   +8 more sources

Chemical Carcinogenesis [PDF]

open access: yesToxicological Sciences, 2010
Understanding the relationship of chemicals to carcinogenesis has progressed significantly since the initial observations of Hill and Pott in the 1700's. Distinguishing between DNA-reactive chemicals and those which increase cancer risk by increasing cell proliferation has been a major breakthrough in delineating overall mechanisms. Competing processes
Samuel M, Cohen, Lora L, Arnold
openaire   +2 more sources

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. [PDF]

open access: yes, 2015
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers ...
H. K. Salem   +999 more
core   +2 more sources

Chemical Carcinogenesis [PDF]

open access: yesAnnals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1976
The first step in the generation of a malignancy seems to be a transformation in the genetic apparatus of a single cell. The ultimate nature of the cancer which appears is a result of the interaction of that change with the control and regulatory apparatus of the whole animal. It appears that the primary cellular change which may be induced by physical,
openaire   +5 more sources

How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men [PDF]

open access: yes, 2005
Tumours in rodent and human colon share many histological and genetic features. To know if rodent models of colon carcinogenesis are good predictors of chemopreventive efficacy in humans, we made a meta-analysis of aspirin, beta-carotene, calcium, and ...
Denis E. Corpet   +4 more
core   +1 more source

Calcium Carbonate Suppresses Haem Toxicity Markers without Calcium Phosphate Side Effect on Colon Carcinogenesis [PDF]

open access: yes, 2010
Red meat intake is associated with increased risk of colorectal cancer. We have previously shown that haemin, haemoglobin and red meat promote carcinogen-induced preneoplastic lesions, aberrant crypt foci, in the colon of rats.
Diane Bahuaud   +13 more
core   +1 more source

17Beta-estradiol modulates gastroduodenal preneoplastic alterations in rats exposed to the carcinogen N-methyl-N'-nitro-nitrosoguanidine [PDF]

open access: yes, 1999
Gastric cancers are a significant cause of morbidity worldwide. Epidemiological studies and animal models show that males have higher incidences of gastric cancers compared with females, suggesting that sex hormones may modulate gastric cancer risk.
Reyher, K K   +4 more
core   +1 more source

Data Quality in Predictive Toxicology: Identification of Chemical Structures and Calculation of Chemical Descriptors

open access: yes, 2000
Every technique for toxicity prediction and for the detection of structure–activity relationships relies on the accurate estimation and representation of chemical and toxicologic properties.
B Pfahringer   +8 more
core   +1 more source

Chemical Carcinogenesis

open access: yes, 1988
Sardinian International Meeting on Modulating Factors in Multistage Chemical Carcinogenesis 1989 Cagliari   +2 more
openaire   +2 more sources

Dehydroalanine and Lysinoalanine in Thermolyzed Casein do not Promote Colon Cancer in the Rat [PDF]

open access: yes, 2008
Thermolysis of proteins produces xenobiotic amino-acids such as the potentially toxic lysinoalanine, and the alkylating agent, dehydro¬alanine, which have been considered possible health hazards.
Bruce, W Robert   +5 more
core   +1 more source

Home - About - Disclaimer - Privacy