Results 1 to 10 of about 5,905,748 (198)

Chemical carcinogenesis [PDF]

Anais da Academia Brasileira de Ciências, 2007
The use of chemical compounds benefits society in a number of ways. Pesticides, for instance, enable foodstuffs to be produced in sufficient quantities to satisfy the needs of millions of people, a condition that has led to an increase in levels of life ...
Paula A. Oliveira, Aura Colaço, Raquel Chaves, Henrique Guedes-Pinto, Luis F. De-La-Cruz P., Carlos Lopes   +5 more
doaj   +8 more sources

What Can Chemical Carcinogenesis Shed Light on the LNT Hypothesis in Radiation Carcinogenesis? [PDF]

Dose-Response, 2019
To protect the public’s health from exposure to physical, chemical, and microbiological agents, it is important that any policy be based on rigorous scientifically based research. The concept of “linear no-threshold” (LNT) has been implemented to provide
James E. Trosko
doaj   +2 more sources

Langerhans cells and NK cells cooperate in the inhibition of chemical skin carcinogenesis

OncoImmunology, 2017
Tissue immunosurveillance is an important mechanism to prevent cancer. Skin treatment with the carcinogen 7,12-dimethylbenz(a)anthracene (DMBA), followed by the tumor promoter 12-O-tetra-decanoyl-phorbol-13-acetate (TPA), is an established murine model ...
Daniela Ortner, Christoph H. Tripp, Kerstin Komenda, Sandrine Dubrac, Bernhard Zelger, Martin Hermann, Wolfgang Doppler, Piotr Z. Tymoszuk, Louis Boon, Björn E. Clausen, Patrizia Stoitzner   +10 more
doaj   +2 more sources

DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells

Environment International, 2022
Benzo[a]pyrene (B[a]P) is a class I carcinogen and hazardous environmental pollutant with genetic toxicity. Understanding the molecular mechanisms underlying genetic deterioration and epigenetic alterations induced by environmental contaminants may ...
Miaoyun Qiu, Nan Zhang, Shuwei Yao, Hanyu Zhou, Xintong Chen, Yangyang Jia, Han Zhang, Xin Li, Yiguo Jiang   +8 more
doaj   +1 more source

Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells

Molecular Cancer, 2020
Background Lung cancer has high morbidity and mortality worldwide with non-small cell lung cancer (NSCLC) accounting for 85% of the cases. Therapies for lung cancer have relatively poor outcomes and further improvements are required.
Nan Zhang, Aruo Nan, Lijian Chen, Xin Li, Yangyang Jia, Miaoyun Qiu, Xin Dai, Hanyu Zhou, Jialu Zhu, Han Zhang, Yiguo Jiang   +10 more
doaj   +1 more source

Circular RNA 406961 interacts with ILF2 to regulate PM2.5-induced inflammatory responses in human bronchial epithelial cells via activation of STAT3/JNK pathways

Environment International, 2020
Fine particulate matter (PM2.5) has been verified to augmented the incidence of pneumonia, asthma, pulmonary fibrosis, and other pulmonary diseases. Airway inflammation is the pathological basis of the respiratory system, and understanding the molecular ...
Yangyang Jia, Xin Li, Aruo Nan, Nan Zhang, Lijian Chen, Hanyu Zhou, Han Zhang, Miaoyun Qiu, Jialu Zhu, Yihui Ling, Yiguo Jiang   +10 more
doaj   +1 more source

Circular RNA circBbs9 promotes PM2.5-induced lung inflammation in mice via NLRP3 inflammasome activation

Environment International, 2020
Fine particulate matter (PM2.5) is one of the most important components of environmental pollutants, and is associated with pulmonary injury. However, the biological mechanisms of pulmonary damage caused by PM2.5 are poorly defined, especially the ...
Meizhen Li, Qiuhan Hua, Yueting Shao, Huixian Zeng, Yufei Liu, Qinqin Diao, Han Zhang, Miaoyun Qiu, Jialu Zhu, Xun Li, Yihui Ling, Rong Zhang, Yiguo Jiang   +12 more
doaj   +1 more source

circCIMT Silencing Promotes Cadmium‐Induced Malignant Transformation of Lung Epithelial Cells Through the DNA Base Excision Repair Pathway

Advanced Science, 2023
Changes in gene expression in lung epithelial cells are detected in cancer tissues during exposure to pollutants, highlighting the importance of gene‐environmental interactions in disease.
Meizhen Li, Wei Chen, Jinjin Cui, Qiuyi Lin, Yufei Liu, Huixian Zeng, Qiuhan Hua, Yihui Ling, Xiaodi Qin, Yindai Zhang, Xueqi Li, Tianshu Lin, Lihua Huang, Yiguo Jiang   +13 more
doaj   +1 more source

Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer

Molecular Cancer, 2019
Circular RNAs are widely expressed in eukaryotic cells and associated with cancer. However, limited studies to date have focused on the potential role of circRNAs in progression of lung cancer.
Lijian Chen, Aruo Nan, Nan Zhang, Yangyang Jia, Xin Li, Yihui Ling, Jiabin Dai, Shaozhu Zhang, Qiaoyuan Yang, Yanni Yi, Yiguo Jiang   +10 more
doaj   +1 more source

The postulated innocuity of lifetime exposure to aluminium should be reappraised

Frontiers in Oncology, 2023
Because of its chemical versatility and abundance in nature, aluminium is employed in a myriad of frequently used products - including cosmetics and food additives - and applications – drinking water purification procedures being an example. Despite what
Stefano J. Mandriota, André-Pascal Sappino   +1 more
doaj   +1 more source