Results 41 to 50 of about 5,905,748 (198)

Parameter Identifiability and Redundancy in a General Class of Stochastic Carcinogenesis Models [PDF]

, 2009
Background Heidenreich et al. (Risk Anal 1997 17 391–399) considered parameter identifiability in the context of the two-mutation cancer model and demonstrated that combinations of all but two of the model parameters are identifiable.
Wolfgang F Heidenreich, Little, Mark, Little Mark P., Li Guangquan, Li, G.Q., Heidenreich, W.F., Li, Guangquan, Heidenreich, Wolfgang, Mark P Little, Little, M.P., Heidenreich Wolfgang F., Guangquan Li   +11 more
core   +2 more sources

Overexpression of lncRNA IGFBP4–1 reprograms energy metabolism to promote lung cancer progression

Molecular Cancer, 2017
Background Reprogrammed energy metabolism as an emerging hallmark of cancer has recently drawn special attention since it facilitate cell growth and proliferation.
Binyao Yang, Lisha Zhang, Yi Cao, Shuai Chen, Jun Cao, Di Wu, Jiansong Chen, Huali Xiong, Zihua Pan, Fuman Qiu, Jinbin Chen, Xiaoxuan Ling, Maosheng Yan, Suli Huang, Shiyu Zhou, Tiegang Li, Lei Yang, Yunchao Huang, Jiachun Lu   +18 more
doaj   +1 more source

Supplementary Table and Figure Legends from A DNA Vaccine against ERBB2 Impairs Chemical Carcinogenesis in Random-Bred Hamsters

, 2011
Supplementary Table and Figure Legends from A DNA Vaccine against ERBB2 Impairs Chemical Carcinogenesis in Random-Bred ...
Federica Cavallo (380294), Giovanni N. Berta (15095123), Susanna Cappia (15095129), Manuela Iezzi (222621), Paolina Salamone (380292), Barbara Mognetti (5420966), Mauro Papotti (314307), Guido Forni (3209517), Michela Spadaro (3528992), Andrea E. Sprio (15095126), Federica Di Scipio (380291), Piero Musiani (222698)   +11 more
core   +1 more source

17Beta-estradiol modulates gastroduodenal preneoplastic alterations in rats exposed to the carcinogen N-methyl-N'-nitro-nitrosoguanidine [PDF]

, 1999
Gastric cancers are a significant cause of morbidity worldwide. Epidemiological studies and animal models show that males have higher incidences of gastric cancers compared with females, suggesting that sex hormones may modulate gastric cancer risk.
Reyher, K K, Cromwell, J, Lauwers, G Y, Campbell-Thompson, M, Shiverick, K T, M. Campbell-Thompson   +5 more
core   +1 more source

Distinctive respiratory toxicity induced by hypoxanthine metabolic disorder from polystyrene microplastics and nanoplastics at environmentally relevant doses: multi-omics insights and experimental validation

Environment International
Microplastics (MPs) and nanoplastics (NPs) are pervasive environmental contaminants, raising concerns about their potential to cause inflammation, oxidative stress, and lung injury through respiratory toxicity.
Xiaole Xu, Mengnan He, Meiqi Lan, Lan Qiu, Jiajing Wang, Chenghui Zhong, Liqiu Qiu, Wenfeng Lu, Jingwen Fang, Shaojuan Wang, Zhizun Deng, Yingxin Chen, Ping Guo, Yun Zhou, Lieyang Fan   +14 more
doaj   +1 more source

Identification of SRXN1 and KRT6A as Key Genes in Smoking-Related Non-Small-Cell Lung Cancer Through Bioinformatics and Functional Analyses

Frontiers in Oncology, 2022
BackgroundLung cancer is the leading cause of cancer-related mortality worldwide. Although cigarette smoking is an established risk factor for lung cancer, few reliable smoking-related biomarkers for non-small-cell lung cancer (NSCLC) are available.
Jiazhen Zhou, Guanqing Jiang, Enwu Xu, Jiaxin Zhou, Lili Liu, Qiaoyuan Yang, Qiaoyuan Yang   +6 more
doaj   +1 more source

Perspective on This Article from A DNA Vaccine against ERBB2 Impairs Chemical Carcinogenesis in Random-Bred Hamsters

, 2011
Perspective on This Article from A DNA Vaccine against ERBB2 Impairs Chemical Carcinogenesis in Random-Bred ...
Federica Cavallo (380294), Giovanni N. Berta (15095123), Susanna Cappia (15095129), Manuela Iezzi (222621), Paolina Salamone (380292), Barbara Mognetti (5420966), Mauro Papotti (314307), Guido Forni (3209517), Michela Spadaro (3528992), Andrea E. Sprio (15095126), Federica Di Scipio (380291), Piero Musiani (222698)   +11 more
core   +1 more source

Cadmium-associated molecular pathways drive gender-specific pathogenesis and prognosis in lung adenocarcinoma

Ecotoxicology and Environmental Safety
Lung adenocarcinoma (LUAD) demonstrates pronounced female predominance and escalating incidence, yet sex-specific environmental determinants remain poorly characterized.
Yusi Yang, Zhiyuan Zhang, Xing He, Zhiya Li, Lin Lu, Yiguo Jiang, Yueting Shao   +6 more
doaj   +1 more source

Absence of promoting potential of bracken fern (Pteridium aquilinum) in rat urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine and uracil

, 1995
Conventional studies on bracken fern (Pteridium aquilinum; PA) carcinogenicity have used high dietary concentrations (around 30%) and long-term exposure (up to 52-70 weeks) without consideration of the multistep character of the chemical carcinogenesis ...
Rocha, Noeme Sousa [UNESP], Fukushima, S., deOliveira, M. L., Rocha, Noeme Sousa, deCamargo, J. L., Rocha, N. S.   +5 more
core   +1 more source

BCScreen: A gene panel to test for breast carcinogenesis in chemical safety screening [PDF]

, 2018
Targeted gene lists have been used in clinical settings to specify breast tumor type, and to predict breast cancer prognosis and response to treatment. Separately, panels have been curated to predict systemic toxicity and xenoestrogen activity as a part ...
Ruthann A. Rudel, Grashow, Rachel G, Watford, Sean M, Rudel, Ruthann A, Sean M. Watford, Rachel G. Grashow, De La Rosa, Vanessa Y, Ackerman, Janet M, Vanessa Y. De La Rosa, Janet M. Ackerman   +9 more
core   +1 more source