Results 41 to 50 of about 80,786 (151)

Rho GTPases: Novel Players in the Regulation of the DNA Damage Response?

Biomolecules, 2015
The Ras-related C3 botulinum toxin substrate 1 (Rac1) belongs to the family of Ras-homologous small GTPases. It is well characterized as a membrane-bound signal transducing molecule that is involved in the regulation of cell motility and adhesion as well
Gerhard Fritz, Christian Henninger
doaj   +1 more source

Marine-Derived Steroids for Cancer Treatment: Search for Potential Selective Glucocorticoid Receptor Agonists/Modulators (SEGRAMs)

Marine Drugs
Steroids, particularly glucocorticoids, are essential components of cancer treatment for both hematological malignancies and solid tumors.
Ekaterina M. Zhidkova, Ekaterina D. Savina, Ekaterina A. Yurchenko, Ekaterina A. Lesovaya   +3 more
doaj   +1 more source

FBXW7 Targets the SPT6‐ΔNp63 Axis for Degradation to Inhibit Esophageal Tumorigenesis Induced by 4‐Nitroquinoline N‐Oxide

MedComm
FBXW7 (F‐box and WD repeat domain‐containing 7) is a classic tumor suppressor that promotes ubiquitylation and degradation of various oncoproteins. Although its tumor suppressor role in many types of cancers has been established, whether and how FBXW7 ...
Jiagui Zhang, Lu Yin, Xiahong You, Xiufang Xiong, Yi Sun   +4 more
doaj   +1 more source

Genetic and Molecular Heterogeneity of Synovial Sarcoma and Associated Challenges in Therapy

Cells
Synovial sarcoma (SS) is one of the most common types of pediatric soft tissue sarcoma (STS) being far less frequent in adults. This STS type is characterized by one specific chromosomal translocation SS18-SSX and the associated changes in signaling ...
Ekaterina A. Lesovaya, Timur I. Fetisov, Beniamin Yu. Bokhyan, Varvara P. Maksimova, Evgeny P. Kulikov, Gennady A. Belitsky, Kirill I. Kirsanov, Marianna G. Yakubovskaya   +7 more
doaj   +1 more source

Chemoprevention of chemical-induced skin cancer by Panax ginseng root extract

Journal of Ginseng Research, 2015
Background: Cancer has emerged as a major health problem globally as a consequence to the increased longevity of the population, changing the environment and life style. Chemoprevention is a new and promising strategy for reducing cancer burden. Recently,
Jyoti Sharma, Pradeep K. Goyal
doaj   +1 more source

Synthesis and Anti-Cancer Activity In Vitro of Synephrine Derivatives

Biomolecules
Glucocorticoids (GCs) are routinely used to treat hematological malignancies; however, long-term treatment with GCs can lead to atrophic and metabolic adverse effects.
Ekaterina M. Zhidkova, Evgeniya S. Oleynik, Ekaterina A. Mikhina, Daria V. Stepanycheva, Diana D. Grigoreva, Lyubov E. Grebenkina, Kirill V. Gordeev, Ekaterina D. Savina, Andrey V. Matveev, Marianna G. Yakubovskaya, Ekaterina A. Lesovaya   +10 more
doaj   +1 more source

Increased Cell Proliferation as a Key Event in Chemical Carcinogenesis: Application in an Integrated Approach for the Testing and Assessment of Non-Genotoxic Carcinogenesis. [PDF]

Int J Mol Sci, 2023
Strupp C, Corvaro M, Cohen SM, Corton JC, Ogawa K, Richert L, Jacobs MN.   +6 more
europepmc   +1 more source

The first artificial cancer in the internal organs of experimental animals

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
In the world history of cancer research, three achievements in Japan were groundbreaking. First, in 1915, Katsusaburo Yamagiwa and Koichi Ichikawa induced skin cancer on the ears of rabbits by the repeated application of coal tar.
Takao SEKIYA
doaj   +1 more source

Temporal single-cell RNA sequencing dataset of gastroesophagus development from embryonic to post-natal stages

Scientific Data
Gastroesophageal disorders and cancers impose a significant global burden. Particularly, the prevalence of esophageal adenocarcinoma (EAC) has increased dramatically in recent years.
Pon Ganish Prakash, Naveen Kumar, Rajendra Kumar Gurumurthy, Cindrilla Chumduri   +3 more
doaj   +1 more source

Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats. [PDF]

Commun Biol, 2022
Oka K, Fujioka S, Kawamura Y, Komohara Y, Chujo T, Sekiguchi K, Yamamura Y, Oiwa Y, Omamiuda-Ishikawa N, Komaki S, Sutoh Y, Sakurai S, Tomizawa K, Bono H, Shimizu A, Araki K, Yamamoto T, Yamada Y, Oshiumi H, Miura K.   +19 more
europepmc   +1 more source