Results 51 to 60 of about 83,835 (249)
Animal Models and Experimental Medicine, EarlyView.The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan +6 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi +6 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/fibroblast growth factor–inducible 14 (Fn14) signaling in SLE‐related ...
Yale Liu +12 more
wiley +1 more source
Mechanisms of Chemical Cooperative Carcinogenesis by Epidermal Langerhans Cells
, 2015 Cutaneous squamous cell carcinoma (SCC) is the most prevalent invasive malignancy with metastatic potential. The epidermis is exposed to a variety of environmental DNA-damaging chemicals, principal among which are polyaromatic hydrocarbons (PAHs ...
Bürgler, Christina D. +19 more
core +1 more source
Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment
BMEMat, EarlyView.Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan +8 more
wiley +1 more source
Machine Learning–Enhanced Fluorescence Cryptography with NADH‐Responsive Polymer Dots
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.This study presents a smart anticounterfeiting system using semiconducting polymer dots (Pdots) that exhibit tunable fluorescence responses to NADH. By integrating these dynamic optical signals with machine learning–based decoding, the work establishes a secure and intelligent encryption platform, showing a novel strategy that links chemical sensing ...
Zhengkun Zhan +7 more
wiley +1 more source
IMMUNITY IN CARCINOGENESIS (II) CHEMICAL CARCINOGENESIS
, 1969 この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されました。Creech et al. (1939) tried to induce resistance against chemical carcinogenesis by immunizing animals with a carcinogen conjugated with certain heterologous proteins and found that it was very difficult to do so. After
安平, 公夫
core
BCScreen: A gene panel to test for breast carcinogenesis in chemical safety screening [PDF]
, 2018 Targeted gene lists have been used in clinical settings to specify breast tumor type, and to predict breast cancer prognosis and response to treatment. Separately, panels have been curated to predict systemic toxicity and xenoestrogen activity as a part ...
Ruthann A. Rudel +9 more
core +1 more source
Environmental Toxicology and Chemistry, EarlyView.Abstract The EcoToxChip project includes RNA‐sequencing data from experiments involving model (Japanese quail, fathead minnow, African clawed frog) and ecological (double‐crested cormorant, rainbow trout, northern leopard frog) species at multiple life stages (whole embryo and adult) exposed to eight chemicals of environmental concern known to perturb ...
Krittika Mittal +7 more
wiley +1 more source
Theoretical considerations for thresholds in chemical carcinogenesis
, 2015 © 2015 Elsevier B.V. There is increasing evidence for non-linear relationships for gene mutations, chromosomal aberrations and even tumor incidences in response to low doses of genotoxic carcinogens.
Kaina, Bernd +8 more
core +1 more source