Results 31 to 40 of about 80,786 (151)

Overexpression of lncRNA IGFBP4–1 reprograms energy metabolism to promote lung cancer progression

Molecular Cancer, 2017
Background Reprogrammed energy metabolism as an emerging hallmark of cancer has recently drawn special attention since it facilitate cell growth and proliferation.
Binyao Yang, Lisha Zhang, Yi Cao, Shuai Chen, Jun Cao, Di Wu, Jiansong Chen, Huali Xiong, Zihua Pan, Fuman Qiu, Jinbin Chen, Xiaoxuan Ling, Maosheng Yan, Suli Huang, Shiyu Zhou, Tiegang Li, Lei Yang, Yunchao Huang, Jiachun Lu   +18 more
doaj   +1 more source

Distinctive respiratory toxicity induced by hypoxanthine metabolic disorder from polystyrene microplastics and nanoplastics at environmentally relevant doses: multi-omics insights and experimental validation

Environment International
Microplastics (MPs) and nanoplastics (NPs) are pervasive environmental contaminants, raising concerns about their potential to cause inflammation, oxidative stress, and lung injury through respiratory toxicity.
Xiaole Xu, Mengnan He, Meiqi Lan, Lan Qiu, Jiajing Wang, Chenghui Zhong, Liqiu Qiu, Wenfeng Lu, Jingwen Fang, Shaojuan Wang, Zhizun Deng, Yingxin Chen, Ping Guo, Yun Zhou, Lieyang Fan   +14 more
doaj   +1 more source

Identification of SRXN1 and KRT6A as Key Genes in Smoking-Related Non-Small-Cell Lung Cancer Through Bioinformatics and Functional Analyses

Frontiers in Oncology, 2022
BackgroundLung cancer is the leading cause of cancer-related mortality worldwide. Although cigarette smoking is an established risk factor for lung cancer, few reliable smoking-related biomarkers for non-small-cell lung cancer (NSCLC) are available.
Jiazhen Zhou, Guanqing Jiang, Enwu Xu, Jiaxin Zhou, Lili Liu, Qiaoyuan Yang, Qiaoyuan Yang   +6 more
doaj   +1 more source

Cadmium-associated molecular pathways drive gender-specific pathogenesis and prognosis in lung adenocarcinoma

Ecotoxicology and Environmental Safety
Lung adenocarcinoma (LUAD) demonstrates pronounced female predominance and escalating incidence, yet sex-specific environmental determinants remain poorly characterized.
Yusi Yang, Zhiyuan Zhang, Xing He, Zhiya Li, Lin Lu, Yiguo Jiang, Yueting Shao   +6 more
doaj   +1 more source

Association Study Among Candidate Genetic Polymorphisms and Chemotherapy-Related Severe Toxicity in Testicular Cancer Patients

Frontiers in Pharmacology, 2019
Testicular cancer is one of the most commonly occurring malignant tumors in young men with fourfold higher rate of incidence and threefold higher mortality rates in Chile than the average global rates.
María A. Lavanderos, Juan P. Cayún, Ángela Roco, Ángela Roco, Christopher Sandoval, Leslie Cerpa, Juan C. Rubilar, Roberto Cerro, Sebastián Molina-Mellico, Cesar Celedón, Berta Cerda, Elena García-Martín, José A. G. Agúndez, Cristián Acevedo, Cristián Acevedo, Karina Peña, Dante D. Cáceres, Dante D. Cáceres, Nelson M. Varela, Luis A. Quiñones   +19 more
doaj   +1 more source

Thiram Effects on HeLa TI Cells

Proceedings
Dithiocarbamate pesticides possess a diverse array of molecular mechanisms, making them multifunctional substances [...]
Varvara Maksimova, Anzhelika Bukina, Guzel Khayrieva, Valeriia Popova, Marianna Yakubovskaya, Kirill Kirsanov   +5 more
doaj   +1 more source

Cytotoxicity and transformation of C3H10T1/2 cells induced by areca nut components

Journal of the Formosan Medical Association, 2016
Betel quid (BQ) chewing is popular in Taiwan and many other countries. There are about 200–600 million BQ chewers in the world. BQ chewing is one major risk factor of oral cancer and oral submucous fibrosis (OSF).
Chien-Yang Yeh, Hsin-Ming Chen, Mei-Chi Chang, Seng-Heng Kok, Jang-Jaer Lee, Bei-En Chang, Po-Yuan Jeng, Chiu-Po Chan, Jiiang-Huei Jeng   +8 more
doaj   +1 more source

Characterization of tumor evolution by functional clonality and phylogenetics in hepatocellular carcinoma

Communications Biology
Hepatocellular carcinoma (HCC) is a molecularly heterogeneous solid malignancy, and its fitness may be shaped by how its tumor cells evolve. However, ability to monitor tumor cell evolution is hampered by the presence of numerous passenger mutations that
Zeynep Kacar, Eric Slud, Doron Levy, Julián Candia, Anuradha Budhu, Marshonna Forgues, Xiaolin Wu, Arati Raziuddin, Bao Tran, Jyoti Shetty, Yotsawat Pomyen, Jittiporn Chaisaingmongkol, Siritida Rabibhadana, Benjarath Pupacdi, Vajarabhongsa Bhudhisawasdi, Nirush Lertprasertsuke, Chirayu Auewarakul, Suleeporn Sangrajrang, Chulabhorn Mahidol, Mathuros Ruchirawat, Xin Wei Wang   +20 more
doaj   +1 more source

Cyclooxygenase-2 Expression in Hamster and Human Pancreatic Neoplasia

Neoplasia: An International Journal for Oncology Research, 2006
Cyclooxygenase-2 (COX-2) has been implicated in the development of gastrointestinal malignancies. The aim of the present study was to determine COX-2 expression/activity throughout stages of experimental and human pancreatic neoplasia.
Pamela L. Crowell, C. Max Schmidt, Michele T. Yip-Schneider, Jesse J. Savage, Dean A. Hertzler, II, William O. Cummings   +5 more
doaj   +1 more source

Evaluation of carcinogenic modes of action for pesticides in fruit on the Swedish market using a text-mining tool

Frontiers in Pharmacology, 2014
Toxicity caused by chemical mixtures has emerged as a significant challenge for toxicologists and risk assessors. Information on individual chemicals’ modes of action is an important part of the hazard identification step.
Ilona eSilins, Anna eKorhonen, Ulla eStenius   +2 more
doaj   +1 more source