Results 21 to 30 of about 5,905,748 (198)

How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men [PDF]

, 2005
Tumours in rodent and human colon share many histological and genetic features. To know if rodent models of colon carcinogenesis are good predictors of chemopreventive efficacy in humans, we made a meta-analysis of aspirin, beta-carotene, calcium, and ...
Denis E. Corpet, Pierre, Fabrice, Pierre, Fabrice H.F., Fabrice Pierre, Corpet, Denis E.   +4 more
core   +1 more source

Chimeric RNA RRM2-C2orf48 plays an oncogenic role in the development of NNK-induced lung cancer

iScience, 2023
Summary: Chimeric RNAs have been used as biomarkers and therapeutic targets for multiple types of cancers. However, less attention has been paid to their mechanism of action in neoplasia.
Jiazhen Zhou, Xinchao Guan, Enwu Xu, Jiaxin Zhou, Rui Xiong, Qiaoyuan Yang   +5 more
doaj   +1 more source

Possible role of genetic predisposition in multigeneration carcinogenesis

, 2022
S.93-103A peculiar phenomenon in experimental transplacental carcinogenesis is that in certain animal species or strains, and with certain types of carcinogens, a tumorigenic risk is observed not only in the F1 generation but also in subsequent F2 and ...
Ernst, H., Aufderheide, M., Mohr, U., Riebe, M., Emura, M.   +4 more
core   +1 more source

CAR requires Gadd45β to promote phenobarbital-induced mouse liver tumors in early stage

Frontiers in Oncology, 2023
Phenobarbital (PB) is an archetypal substance used as a mouse hepatocellular carcinoma (HCC) promotor in established experimental protocols. Our previous results showed CAR is the essential factor for PB induced HCC promotion.
Takeshi Hori, Takeshi Hori, Kosuke Yokobori, Rick Moore, Masahiko Negishi, Tatsuya Sueyoshi   +5 more
doaj   +1 more source

Circular RNA circNIPBL regulates TP53-H179R mutations in NNK-induced bronchial epithelial carcinogenesis

Environment International
Exposure to environmental carcinogens is a significant contributor to cancer development, with genetic and epigenetic alterations playing pivotal roles in the carcinogenic process.
Yufei Liu, Shusen Fang, Tianshu Lin, Wei Chen, Yushan Chen, Ye Wang, Xietian Xiao, Hengfa Zheng, Lulu Liu, Jiayu Zhou, Yan Jiang, Qiuhan Hua, Yiguo Jiang   +12 more
doaj   +1 more source

Circ_0025373 inhibits carbon black nanoparticles-induced malignant transformation of human bronchial epithelial cells by affecting DNA damage through binding to MSH2

Environment International
Carbon black nanoparticles (CBNPs) have been demonstrated to induce DNA damage in epithelial cells. However, the potential of the damage to initiate carcinogenesis and the underlying mechanism remain poorly understood.
Han Zhang, Wenfeng Lu, Lan Qiu, Saifeng Li, Liqiu Qiu, Mengnan He, Xintong Chen, Jiajing Wang, Jingwen Fang, Chenghui Zhong, Meiqi Lan, Xiaole Xu, Yun Zhou   +12 more
doaj   +1 more source

CircRNA0052011 modulates DNA damage and repair via FEN1 ubiquitination to mitigate polystyrene nanoplastics-induced genotoxicity in the lung

Environment International
Polystyrene nanoplastics (PS-NPs) are one type of environmental pollutants that can penetrate biological barriers and accumulate within cells due to their small particle size. This characteristic raises concerns about their potential respiratory toxicity.
Meiqi Lan, Chenghui Zhong, Xiaole Xu, Mengnan He, Lieyang Fan, Wenfeng Lu, Liqiu Qiu, Jingwen Fang, Jiajing Wang, Shaojuan Wang, Zhizun Deng, Yingxin Chen, Lan Qiu, Xinyu Chen, Yiguo Jiang, Yun Zhou   +15 more
doaj   +1 more source

Supplementary Figure 1 from A DNA Vaccine against ERBB2 Impairs Chemical Carcinogenesis in Random-Bred Hamsters

, 2011
Supplementary Figure 1 from A DNA Vaccine against ERBB2 Impairs Chemical Carcinogenesis in Random-Bred ...
Federica Cavallo (380294), Giovanni N. Berta (15095123), Susanna Cappia (15095129), Manuela Iezzi (222621), Paolina Salamone (380292), Barbara Mognetti (5420966), Mauro Papotti (314307), Guido Forni (3209517), Michela Spadaro (3528992), Andrea E. Sprio (15095126), Federica Di Scipio (380291), Piero Musiani (222698)   +11 more
core   +1 more source

Urethane-induced lung carcinogenesis

, 2021
Chemical induced carcinogenesis together with genetically engineered mouse models represent important approaches for the study of the complex mechanisms involving genotype and environmental factors in cancer development, including lung cancer.
Schioppa T., Sozio F., Sozzani S., Del Prete A.   +3 more
core   +1 more source

Expression of Bioactive Chemerin by Keratinocytes Inhibits Late Stages of Tumor Development in a Chemical Model of Skin Carcinogenesis

Frontiers in Oncology, 2019
Chemerin is a multifunctional protein acting mainly through the G protein-coupled receptor ChemR23/CMKLR1/Chemerin1. Its expression is frequently downregulated in human tumors, including in melanoma and squamous cell carcinoma of the skin and anti ...
Ingrid Dubois-Vedrenne, Olivier De Henau, Virginie Robert, Francina Langa, Joaquim Javary, Diana Al Delbany, Olivier Vosters, Edgar Angelats-Canals, Maxime Vernimmen, Souphalone Luangsay, Souphalone Luangsay, Valérie Wittamer, Marc Parmentier   +12 more
doaj   +1 more source