Results 21 to 30 of about 80,786 (151)

Circular RNA circNIPBL regulates TP53-H179R mutations in NNK-induced bronchial epithelial carcinogenesis

Environment International
Exposure to environmental carcinogens is a significant contributor to cancer development, with genetic and epigenetic alterations playing pivotal roles in the carcinogenic process.
Yufei Liu, Shusen Fang, Tianshu Lin, Wei Chen, Yushan Chen, Ye Wang, Xietian Xiao, Hengfa Zheng, Lulu Liu, Jiayu Zhou, Yan Jiang, Qiuhan Hua, Yiguo Jiang   +12 more
doaj   +1 more source

Circ_0025373 inhibits carbon black nanoparticles-induced malignant transformation of human bronchial epithelial cells by affecting DNA damage through binding to MSH2

Environment International
Carbon black nanoparticles (CBNPs) have been demonstrated to induce DNA damage in epithelial cells. However, the potential of the damage to initiate carcinogenesis and the underlying mechanism remain poorly understood.
Han Zhang, Wenfeng Lu, Lan Qiu, Saifeng Li, Liqiu Qiu, Mengnan He, Xintong Chen, Jiajing Wang, Jingwen Fang, Chenghui Zhong, Meiqi Lan, Xiaole Xu, Yun Zhou   +12 more
doaj   +1 more source

CircRNA0052011 modulates DNA damage and repair via FEN1 ubiquitination to mitigate polystyrene nanoplastics-induced genotoxicity in the lung

Environment International
Polystyrene nanoplastics (PS-NPs) are one type of environmental pollutants that can penetrate biological barriers and accumulate within cells due to their small particle size. This characteristic raises concerns about their potential respiratory toxicity.
Meiqi Lan, Chenghui Zhong, Xiaole Xu, Mengnan He, Lieyang Fan, Wenfeng Lu, Liqiu Qiu, Jingwen Fang, Jiajing Wang, Shaojuan Wang, Zhizun Deng, Yingxin Chen, Lan Qiu, Xinyu Chen, Yiguo Jiang, Yun Zhou   +15 more
doaj   +1 more source

Expression of Bioactive Chemerin by Keratinocytes Inhibits Late Stages of Tumor Development in a Chemical Model of Skin Carcinogenesis

Frontiers in Oncology, 2019
Chemerin is a multifunctional protein acting mainly through the G protein-coupled receptor ChemR23/CMKLR1/Chemerin1. Its expression is frequently downregulated in human tumors, including in melanoma and squamous cell carcinoma of the skin and anti ...
Ingrid Dubois-Vedrenne, Olivier De Henau, Virginie Robert, Francina Langa, Joaquim Javary, Diana Al Delbany, Olivier Vosters, Edgar Angelats-Canals, Maxime Vernimmen, Souphalone Luangsay, Souphalone Luangsay, Valérie Wittamer, Marc Parmentier   +12 more
doaj   +1 more source

Carcinogenicidade do carbendazim e seus metabólitos

Química Nova, 2014
The carcinogenic potential of carbendazim and its metabolites was analyzed using statistical treatment of electronic parameters obtained from DFT/ 6-311++G(d,p) and AM1 calculations.
Renato C. Silva, Karina A. Barros, Antonio C. Pavão   +2 more
doaj   +1 more source

Role of Macrophages in Cytotoxicity, Reactive Oxygen Species Production and DNA Damage in 1,2-Dichloropropane-Exposed Human Cholangiocytes In Vitro

Toxics, 2021
1,2-Dichloropropane (1,2-DCP), a synthetic chlorinated organic compound, was extensively used in the past in offset color proof-printing. In 2014, the International Agency for Research on Cancer (IARC) reclassified 1,2-DCP from its initial Group 3 to ...
Abigail Ekuban, Cai Zong, Frederick Adams Ekuban, Yusuke Kimura, Ryoya Takizawa, Kota Morikawa, Kazuo Kinoshita, Sahoko Ichihara, Seiichiroh Ohsako, Gaku Ichihara   +9 more
doaj   +1 more source

Sawmill Chemicals and Carcinogenesis [PDF]

Environmental Health Perspectives, 2001
Workers in wood industries are exposed to variable medleys of chemicals, both natural and synthetic. Additional exposures include fungi, bacteria, bark and wood dusts, solvents, paints, and various other wood coatings. These individual and conglomerate exposures have been associated with diverse occupational illnesses and hazards, including cancers. In
openaire   +3 more sources

Integration of adeno-associated virus (AAV) into the genomes of most Thai and Mongolian liver cancer patients does not induce oncogenesis

BMC Genomics, 2021
Background Engineered versions of adeno-associated virus (AAV) are commonly used in gene therapy but evidence revealing a potential oncogenic role of natural AAV in hepatocellular carcinoma (HCC) has raised concerns.
Alejandro A. Schäffer, Dana A. Dominguez, Lesley M. Chapman, E. Michael Gertz, Anuradha Budhu, Marshonna Forgues, Jittiporn Chaisaingmongkol, Siritida Rabibhadana, Benjarath Pupacdi, Xiaolin Wu, Enkhjargal Bayarsaikhan, Curtis C. Harris, Mathuros Ruchirawat, Eytan Ruppin, Xin Wei Wang   +14 more
doaj   +1 more source

Club cells form lung adenocarcinomas and maintain the alveoli of adult mice

eLife, 2019
Lung cancer and chronic lung diseases impose major disease burdens worldwide and are caused by inhaled noxious agents including tobacco smoke. The cellular origins of environmental-induced lung tumors and of the dysfunctional airway and alveolar ...
Magda Spella, Ioannis Lilis, Mario AA Pepe, Yuanyuan Chen, Maria Armaka, Anne-Sophie Lamort, Dimitra E Zazara, Fani Roumelioti, Malamati Vreka, Nikolaos I Kanellakis, Darcy E Wagner, Anastasios D Giannou, Vasileios Armenis, Kristina AM Arendt, Laura V Klotz, Dimitrios Toumpanakis, Vassiliki Karavana, Spyros G Zakynthinos, Ioanna Giopanou, Antonia Marazioti, Vassilis Aidinis, Rocio Sotillo, Georgios T Stathopoulos   +22 more
doaj   +1 more source

Circ_0008657 regulates lung DNA damage induced by hexavalent chromium through the miR-203a-3p/ATM axis

Environment International
Hexavalent chromium [Cr (VI)] is an important environmental pollutant and may cause lung injury when inhaled into the human body. Cr (VI) is genotoxic and can cause DNA damage, although the underlying epigenetic mechanisms remain unclear. To simulate the
Wei Chen, Zehao Chen, Yangyang Jia, Yaozheng Guo, Liting Zheng, Shuwei Yao, Yueting Shao, Meizhen Li, Rulin Mao, Yiguo Jiang   +9 more
doaj   +1 more source