Results 11 to 20 of about 6,731 (160)

Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms. [PDF]

Hemasphere, 2021
Mutations in the calreticulin (CALR) gene are seen in about 30% of essential thrombocythemia and primary myelofibrosis patients. To address the contribution of the human CALR mutants to the pathogenesis of myeloproliferative neoplasms (MPNs) in an endogenous context, we modeled the CALRdel52 and CALRins5 mutants by induced pluripotent stem cell (iPSC ...
Secardin L, Gomez Limia C, da Silva-Benedito S, Lordier L, El-Khoury M, Marty C, Ianotto JC, Raslova H, Constantinescu SN, Bonamino MH, Vainchenker W, Monte-Mor B, Di Stefano A, Plo I.   +13 more
europepmc   +2 more sources

HLA-B Serine 116 Confers Protection Against Severe COVID-19 in a Cohort From Rio de Janeiro, Brazil. [PDF]

HLA
ABSTRACT COVID‐19 is a respiratory disease caused by SARS‐CoV‐2, in which severe outcomes are primarily driven by an exacerbated immune response. The HLA region has been extensively investigated in COVID‐19 due to its central role in the immune response, although genetic associations vary across populations.
Pereira MADS, Ferreira SN, Gonçalves CCA, Reis MCD, Zampier CDP, Leitão IC, Lopes MSA, Rossi AD, Soares-Lima SC, Galliez RM, Barroso SPC, Junior ODCF, Tanuri A, Castiñeiras TMPP, Rossi ÁD, Cardoso CC.   +15 more
europepmc   +2 more sources

The Prominent Role of HMGA Proteins in the Early Management of Gastrointestinal Cancers. [PDF]

Biomed Res Int, 2019
GI tumors represent a heterogeneous group of neoplasms concerning their natural history and molecular alterations harbored. Nevertheless, these tumors share very high incidence and mortality rates worldwide and patients’ poor prognosis. Therefore, the identification of specific biomarkers could increase the development of personalized medicine, in ...
Meireles Da Costa N, Ribeiro Pinto LF, Nasciutti LE, Palumbo A.   +3 more
europepmc   +2 more sources

Insights into the Oncogenic, Prognostic, and Immunological Role of BRIP1 in Pan‐Cancer: A Comprehensive Data‐Mining‐Based Study

Journal of Oncology, Volume 2023, Issue 1, 2023., 2023
Background. BRCA1 interacting helicase 1 (BRIP1), an ATP‐dependent DNA helicase which belongs to an Iron‐Sulfur (Fe‐S) helicase cluster family with a DEAH domain, plays a key role in DNA damage and repair, Fanconi anemia, and development of several cancers including breast and ovarian cancer.
Yongru Liu, Xi Wu, Yunlu Feng, Qingwei Jiang, Shengyu Zhang, Qiang Wang, Aiming Yang, Yanqing Liu   +7 more
wiley   +1 more source

Potential Therapeutic Effects of Underground Parts of Kalanchoe gastonis-bonnieri on Benign Prostatic Hyperplasia. [PDF]

Evid Based Complement Alternat Med, 2019
Benign Prostatic Hyperplasia (BPH) affects mainly older men. It is estimated to affect 50% of 51‐60‐year‐old men and 70% of 61‐70‐year‐old men. BPH is a nonmalignant proliferation of epithelial and stromal cells of the prostate gland regions. Despite the use of conventional pharmacological therapy, herbal medicines are used in BPH therapy, and several ...
Palumbo A, Casanova LM, Corrêa MFP, Da Costa NM, Nasciutti LE, Costa SS.   +5 more
europepmc   +2 more sources

Different Genotype Distribution of Human Papillomavirus between Cervical and Esophageal Cancers: A Study in Both High‐Incidence Areas, Xinjiang, China

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
The aim of this study is to reveal the certain human papillomavirus (HPV) genotype distribution between cervical cancer and esophageal cancer in the both high‐incidence geographic regions. For this study, we collected and detected the infection of HPV in 120 paraffin‐embedded esophageal tissues and 152 paraffin‐embedded cervical tissues, respectively ...
Yi Zheng, Yage Fan, Yan Zeng, Shiyu Liu, Limin Gao, Maciej Gagat   +5 more
wiley   +1 more source

Galectin-3 and beta-catenin expression in premalignant and carcinomatous lesions in tongue of mice [PDF]

, 2011
INTRODUÇÃO: A galectina-3 (GAL3) apresenta importantes papéis na biologia tumoral e recentemente foi mostrada a sua participação na via de sinalização Wnt, translocando a beta-catenina para o núcleo.
CARDOSO, Sérgio Vitorino, CHAMMAS, Roger, FARIA, Paulo Rogério de, LOYOLA, Adriano Mota, MENDONÇA, Daniella Fernandes, NONOGAKI, Suely, SANT'ANA, Juliana Moreira de Almeida   +6 more
core   +1 more source

The influence of tumor invasion in anastomotic line on survival of patient with gastric stump cancer [PDF]

, 2008
RACIONAL: O câncer do coto gástrico desenvolve- se no remanescente gástrico de gastrectomia realizada há pelo menos 5 anos por doença benigna e os sítios mais comuns de acometimento são próximo à anastomose e na pequena curvatura. Considera-se que o coto
BRESCIANI, Cláudio José Caldas, CARRASCO, Ana Lúcia Granja Scarabel Nogueira, CECCONELLO, Ivan, PEREZ, Rodrigo Oliva, ZILBERSTEIN, Bruno   +4 more
core   +2 more sources

A pilot study of the effects of hormone therapy on normal breast tissue of postmenopausal women [PDF]

, 2006
PURPOSE: to analyze breast tissue of postmenopausal women before and after six months of continuous combined estrogen-progestin replacement therapy (0.625 mg conjugated equine estrogens associated with 2.5 mg medroxyprogesterone acetate).
Baracat, Edmund Chada, Dardes, Rita de Cássia de Maio, Elias, Simone, Heinke, Thais, Kemp, Claudio, Lima, Geraldo Rodrigues de, Waitzberg, Angela Flávia Logullo   +6 more
core   +3 more sources

CARACTERÍSTICAS MOLECULARES ASSOCIADAS AO CÂNCER DE ESTÔMAGO

Revista de Ciências da Saúde Nova Esperança, 2005
O Câncer gástrico apresenta altas taxas de mortalidade devido ao diagnóstico tardio da doença. O surgimento de novas técnicas laboratoriais altamente sensíveis e específicas é de fundamental importância para uma análise e detecção precoce da ...
Henrique Douglas Melo Coutinho
doaj   +1 more source