Results 11 to 20 of about 242 (68)

Insights into the Oncogenic, Prognostic, and Immunological Role of BRIP1 in Pan‐Cancer: A Comprehensive Data‐Mining‐Based Study

Journal of Oncology, Volume 2023, Issue 1, 2023., 2023
Background. BRCA1 interacting helicase 1 (BRIP1), an ATP‐dependent DNA helicase which belongs to an Iron‐Sulfur (Fe‐S) helicase cluster family with a DEAH domain, plays a key role in DNA damage and repair, Fanconi anemia, and development of several cancers including breast and ovarian cancer.
Yongru Liu, Xi Wu, Yunlu Feng, Qingwei Jiang, Shengyu Zhang, Qiang Wang, Aiming Yang, Yanqing Liu   +7 more
wiley   +1 more source

Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms

HemaSphere, Volume 5, Issue 7, July 2021., 2021
Mutations in the calreticulin (CALR) gene are seen in about 30% of essential thrombocythemia and primary myelofibrosis patients. To address the contribution of the human CALR mutants to the pathogenesis of myeloproliferative neoplasms (MPNs) in an endogenous context, we modeled the CALRdel52 and CALRins5 mutants by induced pluripotent stem cell (iPSC ...
Lise Secardin, Cintia Gomez Limia, Suzana da Silva‐Benedito, Larissa Lordier, Mira El‐Khoury, Caroline Marty, Jean‐Christophe Ianotto, Hana Raslova, Stefan N. Constantinescu, Martín Hernán Bonamino, William Vainchenker, Barbara Monte‐Mor, Antonio Di Stefano, Isabelle Plo   +13 more
wiley   +1 more source

Different Genotype Distribution of Human Papillomavirus between Cervical and Esophageal Cancers: A Study in Both High‐Incidence Areas, Xinjiang, China

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
The aim of this study is to reveal the certain human papillomavirus (HPV) genotype distribution between cervical cancer and esophageal cancer in the both high‐incidence geographic regions. For this study, we collected and detected the infection of HPV in 120 paraffin‐embedded esophageal tissues and 152 paraffin‐embedded cervical tissues, respectively ...
Yi Zheng, Yage Fan, Yan Zeng, Shiyu Liu, Limin Gao, Maciej Gagat   +5 more
wiley   +1 more source

Segregação mitótica induzida pelo edulcorante L-Aspartil-L-Fenilalanina-Metil-Ester (aspartame) em células diplóides de Aspergillus nidulans - DOI: 10.4025/actascibiolsci.v25i1.2121

Acta Scientiarum: Biological Sciences, 2008
O presente trabalho demonstra o efeito recombinagênico do edulcorante artificial L-Aspartil-L-Fenilalanina-Metil-Ester (aspartame), amplamente utilizado em dietas hipocalóricas e de baixo consumo de glicose.
Josil Santos Gebara, Carmem Boto Querol, Munif Gebara, Marialba Avezum Alves Castro Prado   +3 more
doaj   +1 more source

Biologia molecular dos tumores do trato digestivo

Clinical and Biomedical Research, 2022
Uma revolução no entendimento da gênese do câncer humano vem acontecendo, e sua natureza fundamentalmente genética foi reconhecida. Os cânceres gastrointestinais apresentam alta incidência e prognóstico reservado na maioria dos casos quando da sua ...
Carlos F. Dillenburg, Luis Fernando Moreira   +1 more
doaj  

Carcinogênese experimental com DMBA em solução

Revista da Faculdade de Odontologia de Porto Alegre, 2021
Inoculou-se em 14 ratos Wistar uma solução de 9-10-dimetil-1-2-benzantraceno (DMBA), em óleo de amendoim, na região pré-auricular. Após um período variável entre 70 e 312 dias, observou-se no local da injeção, a formação de tumor de consistência fibrosa,
José Alberto B. Opitz, Hardy Ebling
doaj   +1 more source

Análise Morfológica Comparativa da Carcinogênese Química Cutânea entre Camundongo (Mus Musculus) e Gerbilho (Meriones Unguiculatos)

Revista Brasileira de Cancerologia, 2023
Foi estudada a resposta da pele de gerbilho à indução química de tumores, comparando-se as alterações morfológicas iniciais com aquelas que ocorrem na pele do camundongo.
Maria Angélica Guzmán Silva, Jorge S. P. Guimarães   +1 more
doaj   +1 more source

The Prominent Role of HMGA Proteins in the Early Management of Gastrointestinal Cancers

BioMed Research International, Volume 2019, Issue 1, 2019., 2019
GI tumors represent a heterogeneous group of neoplasms concerning their natural history and molecular alterations harbored. Nevertheless, these tumors share very high incidence and mortality rates worldwide and patients’ poor prognosis. Therefore, the identification of specific biomarkers could increase the development of personalized medicine, in ...
Nathalia Meireles Da Costa, Luis Felipe Ribeiro Pinto, Luiz Eurico Nasciutti, Antonio Palumbo Jr., Qiang Tong   +4 more
wiley   +1 more source

Determination of SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, and RAGE rs1800625 Single Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma

Disease Markers, Volume 2019, Issue 1, 2019., 2019
Purpose. To determine the frequency of the genotype of signal transducer and activator of transcription protein 3 (STAT3) rs744166, sirtuin (SIRT1) rs12778366, fibroblast growth factor (FGFR2) rs2981582, and advanced glycosylation end product‐specific receptor (RAGE) rs1800625 gene polymorphisms in patients with laryngeal squamous cell carcinoma (LSCC).
Virgilijus Uloza, Toma Tamauskaite, Alvita Vilkeviciute, Agne Pasvenskaite, Vykintas Liutkevicius, Rasa Liutkeviciene, Massimiliano M. Corsi Romanelli   +6 more
wiley   +1 more source

Potential Therapeutic Effects of Underground Parts of Kalanchoe gastonis-bonnieri on Benign Prostatic Hyperplasia

Evidence-Based Complementary and Alternative Medicine, Volume 2019, Issue 1, 2019., 2019
Benign Prostatic Hyperplasia (BPH) affects mainly older men. It is estimated to affect 50% of 51‐60‐year‐old men and 70% of 61‐70‐year‐old men. BPH is a nonmalignant proliferation of epithelial and stromal cells of the prostate gland regions. Despite the use of conventional pharmacological therapy, herbal medicines are used in BPH therapy, and several ...
Antonio Palumbo, Livia Marques Casanova, Maria Fernanda Paresqui Corrêa, Nathalia Meireles Da Costa, Luiz Eurico Nasciutti, Sônia Soares Costa, Ester Pagano   +6 more
wiley   +1 more source