Results 31 to 40 of about 385,377 (294)
Role of Oncogenes and Tumor-suppressor Genes in Carcinogenesis: A Review
Anticancer Research, 2020 Cancer is a medical condition which has a molecular basis. Proto-oncogenes are the first regulatory factors of this biological process. They act in transmitting signals, resulting as growth factors. Modifications of these genes, called oncogenes, lead to
E. Kontomanolis +11 more
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Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Wei He +11 more
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Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2003 Cadmium is a heavy metal of considerable environmental and occupational concern. Cadmium compounds are classified as human carcinogens by several regulatory agencies. The most convincing data that cadmium is carcinogenic in humans comes from studies indicating occupational cadmium exposure is associated with lung cancer.
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Barretts's carcinogenesis [PDF]
Pathology International, 2019 Barrett's esophagus is considered a precancerous lesion of esophageal adenocarcinoma (EAC). Long‐segment Barrett's esophagus, which is generally associated with intestinal metaplasia, has a higher rate of carcinogenesis than short‐segment Barrett's esophagus, which is mainly composed of cardiac‐type mucosa.
Ryoji Kushima +5 more
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Nature Communications, 2017 MicroRNAs have important roles in regulating tumor development, progression and metastasis. Here, the authors demonstrate the tumor-suppressive functions of miRNA141 in prostate cancer stem cells mediated by directly targeting CD44, Rho GTPase protein ...
Can Liu +13 more
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EJC Supplements, 2015 Glucocorticoids (GCs) are widely used in treatment of many cancer types due to its ability to induce apoptosis in malignant cells in blood cancer therapy, and to prevent nausea, emesis and chemotherapy-associated hepatotoxicity in case of solid tumors ...
E. Lesovaya +9 more
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Frontiers in Neuroscience, 2023 IntroductionGlioblastoma (GBM) is notorious for its clinical and molecular heterogeneity, contributing to therapeutic failure and a grim prognosis. WWOX is one of the tumor suppressor genes important in nervous tissue or related pathologies, which was ...
Żaneta Kałuzińska-Kołat +4 more
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Metals and Mechanisms of Carcinogenesis.
Annual Review of Pharmacology and Toxicology, 2019 Metal exposure is pervasive and not limited to sporadic poisoning events or toxic waste sites. Hundreds of millions of people around the globe are affected by chronic metal exposure, which is associated with serious health concerns, including cancer, as ...
Q. Chen, Thomas L DesMarais, Max Costa
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Apoptosis and carcinogenesis [PDF]
British Medical Bulletin, 1997 Many tumours are characterised by increased levels of apoptosis. This observation establishes significance for this process in tumour development, but it does little to elucidate the nature of this role, nor does it yield information relevant to the early stages of carcinogenesis.
Alan R Clarke, Scott K Lyons
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Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
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