Results 11 to 20 of about 327,951 (318)

In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer

BMC Urology, 2021
Background WW Domain Containing Oxidoreductase (WWOX) belongs to the unusual tumor suppressors, whose molecular function is not fully understood in bladder cancer, especially regarding interaction with Activator Protein 2 (AP-2) α/γ transcription factors.
Żaneta Kałuzińska, Damian Kołat, Katarzyna Kośla, Magdalena Orzechowska, Andrzej K. Bednarek, Elżbieta Płuciennik   +5 more
doaj   +1 more source

Tumor metabolism and associated serum metabolites define prognostic subtypes of Asian hepatocellular carcinoma

Scientific Reports, 2021
Treatment effectiveness in hepatocellular carcinoma (HCC) depends on early detection and precision-medicine-based patient stratification for targeted therapies.
Yotsawat Pomyen, Anuradha Budhu, Jittiporn Chaisaingmongkol, Marshonna Forgues, Hien Dang, Mathuros Ruchirawat, Chulabhorn Mahidol, Xin Wei Wang, the TIGER-LC Consortium   +8 more
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Functional genomics of AP-2α and AP-2γ in cancers: in silico study

BMC Medical Genomics, 2020
Background Among all causes of death, cancer is the most prevalent and is only outpaced by cardiovascular diseases. Molecular theory of carcinogenesis states that apoptosis and proliferation are regulated by groups of tumor suppressors or oncogenes ...
Damian Kołat, Żaneta Kałuzińska, Magdalena Orzechowska, Andrzej K. Bednarek, Elżbieta Płuciennik   +4 more
doaj   +1 more source

Prognostic significance of AP-2α/γ targets as cancer therapeutics

Scientific Reports, 2022
Identifying genes with prognostic importance could improve cancer treatment. An increasing number of reports suggest the existence of successful strategies based on seemingly “untargetable” transcription factors.
Damian Kołat, Żaneta Kałuzińska, Andrzej K. Bednarek, Elżbieta Płuciennik   +3 more
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Expression and Significance of AQP3 in Cutaneous Lesions

Analytical Cellular Pathology, 2021
Aquaporin 3 (AQP3) is the membrane channel of water and involved in fluid homeostasis. The aim of this study was to reveal the expression and significance of AQP3 in cutaneous lesions.
Dongfeng Niu, Yanhua Bai, Qian Yao, Wei Hou, Lixin Zhou, Xiaozheng Huang, Chen Zhao   +6 more
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Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells

Molecular Cancer, 2020
Background Lung cancer has high morbidity and mortality worldwide with non-small cell lung cancer (NSCLC) accounting for 85% of the cases. Therapies for lung cancer have relatively poor outcomes and further improvements are required.
Nan Zhang, Aruo Nan, Lijian Chen, Xin Li, Yangyang Jia, Miaoyun Qiu, Xin Dai, Hanyu Zhou, Jialu Zhu, Han Zhang, Yiguo Jiang   +10 more
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Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice [PDF]

, 2013
Cervical cancer is caused by human papillomavirus (HPV) in collaboration with other non-viral factors. The uterine cervix is hormone responsive and female hormones have been implicated in the pathogenesis of the disease.
Son, Jieun, Park, Jung Wook, Lambert, Paul F., Chung, Sang-Hyuk   +3 more
core   +1 more source

MYCN-regulated miRNAs Inhibit Secretion of the Tumor Suppressor DICKKOPF-3 (DKK3) in Neuroblastoma [PDF]

, 2011
The MYCN oncogene is frequently amplified in neuroblastoma. It is one of the most consistent markers of a bad prognosis for this disease. Dickkopf-3 (DKK3) is a secreted protein of the Dickkopf family of Wnt regulators. It functions as a tumor suppressor
Tømte, Ellen, Christer Einvik, Flægstad, Trond, Henriksen, Jørn R., Henriksen, Jørn Remi, Dirk Geerts, Tommy Martinsson, Bjørn Helge Haug, Kogner, Per, Sveinbjørnsson, Baldur, Haug, Bjørn Helge, Einvik, Christer, Martinsson, Tommy,, Per Kogner, Trond Flægstad, Buechner, Jochen, Jørn R. Henriksen, Ellen Tømte, Baldur Sveinbjørnsson, Jochen Buechner, Martinsson, Tommy, Geerts, Dirk, Henriksen, Jørn R   +22 more
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Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer

Molecular Cancer, 2019
Circular RNAs are widely expressed in eukaryotic cells and associated with cancer. However, limited studies to date have focused on the potential role of circRNAs in progression of lung cancer.
Lijian Chen, Aruo Nan, Nan Zhang, Yangyang Jia, Xin Li, Yihui Ling, Jiabin Dai, Shaozhu Zhang, Qiaoyuan Yang, Yanni Yi, Yiguo Jiang   +10 more
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Calcium Carbonate Suppresses Haem Toxicity Markers without Calcium Phosphate Side Effect on Colon Carcinogenesis [PDF]

, 2010
Red meat intake is associated with increased risk of colorectal cancer. We have previously shown that haemin, haemoglobin and red meat promote carcinogen-induced preneoplastic lesions, aberrant crypt foci, in the colon of rats.
Diane Bahuaud, Sylviane Taché, Bahuaud, Diane, Taché, Sylviane, Ossama Allam, Salah Eldin Allam, Ossama, Denis E. Corpet, Pierre, Fabrice, Allam, Ossama, Naud, Nathalie, Pierre, Fabrice H.F., Nathalie Naud, Corpet, Denis E., Fabrice H. F. Pierre   +13 more
core   +1 more source