Results 41 to 50 of about 285,650 (298)
Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer
Frontiers in Oncology, 2021 Alpha-fetoprotein (AFP) entrance into cancer cells is mediated by AFP receptors (AFPRs) and exerts malignant effects. Therefore, understanding the structure of AFPRs will facilitate the development of rational approaches for vaccine design, drug delivery,
Bo Lin +6 more
doaj +1 more source
Endothelins and carcinogenesis
Postępy Higieny i Medycyny Doświadczalnej, 2016 Endothelins are a family of four endogenous peptides (ET-1, ET-2, ET-3, ET-4) secreted primarily in an inactive form by the endothelium. They are activated with the participation of converting enzyme. Numerous studies have described their pleiotropic biological activity.
Jacek Olender +3 more
openaire +3 more sources
The role of circular RNAs in regulating cytokine signaling in cancer
FEBS Open Bio, EarlyView.Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi +4 more
wiley +1 more source
Tumor Associated Macrophages in Kidney Cancer
Analytical Cellular Pathology, 2016 Tumor associated macrophages (TAMs) are an important element of tumor stroma. They originate from blood monocytes attracted by chemokines and cytokines produced by tumor cells and, being instructed by tumor microenvironment, develop into potent tumor ...
Olga V. Kovaleva +3 more
doaj +1 more source
Cell & Bioscience, 2019 Mitochondria are energy factories of cells and are important pivots for intracellular interactions with other organelles. They interact with the endoplasmic reticulum, peroxisomes, and nucleus through signal transduction, vesicle transport, and membrane ...
MengFang Xia +5 more
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Cells, 2022 Following the invention of high-throughput sequencing, cancer research focused on investigating disease-related alterations, often inadvertently omitting tumor heterogeneity.
Damian Kołat +3 more
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Matrix: a complex amalgam of structures and functions in tumor microenvironment
FEBS Open Bio, EarlyView.The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis +3 more
wiley +1 more source
Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men
Nature Communications, 2023 The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from Ghana and the ...
Tsion Zewdu Minas +22 more
doaj +1 more source
Liver‐specific lncRNAs associated with liver cancers
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina +3 more
wiley +1 more source
De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens
Nature Communications, 2019 Tiling-sgRNA designs allow the in situ evaluation of protein domain functions. Here the authors present ProTiler - a computational method to predict CRISPR knockout hyper-sensitive regions, revealing previously unannotated domains.
Wei He +11 more
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