Results 31 to 40 of about 13,262 (168)

Merkel Cell Carcinoma of the Mandible: A Case of Spontaneous Acceleration of the Growth

Reports, 2019
A 78 year old Caucasian woman, was admitted to the hospital for evaluation of a mass to the anterior surface of the left mandibular angle and left submandibular area present for the past year with rapid acceleration of growth over three weeks prior to ...
Mansoor Choudhry, Muhammad Danial, James Bolduc, Syed A. A. Rizvi, Pedro Rabionet, John Westine   +5 more
doaj   +1 more source

Neuroendocrine (Merkel cell) carcinoma of the auricle [PDF]

Archive of Oncology, 2004
Merkel cell carcinoma is a rare locally aggressive malignancy. Most commonly occurs in the head and neck area and only six cases on the auricle have been reported.
Divani Smaroula, Vardouli Anna, Reppas Spiros, Alexopoulou Vana, Skoulakis Charalampos, Valagiannis Dimitris   +5 more
doaj   +1 more source

MERKEL CELL CARCINOMA – PRO AND CONS ASPECTS FOR SENTINEL LYMPH NODE BIOPSY [PDF]

Romanian Medical Journal, 2019
Merkel cell carcinoma represents an aggressive histopathological subtype of skin cancer with a high propensity to spread via lymphatic route. Once the benefits of the sentinel lymph node detection have been proven in malignant melanoma, the effectiveness
Nicolae Bacalbasa, Irina Balescu, Mihai Dimitriu, Mihaela Vilcu, Iulian Brezean   +4 more
doaj   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Merkel-Cell Carcinoma

New England Journal of Medicine
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that is highly radiosensitive and immunogenic. Immunotherapy is the primary treatment of advanced disease, and immune checkpoint inhibitors show promise as neoadjuvant or adjuvant therapy in patients with high-risk resectable MCC.
Zunaid Ahmed, Willem Visser
  +8 more sources

Concomitant chronic lymphocytic leukemia and Merkel cell carcinoma

Dermatologica Sinica, 2015
We present the case of a 69-year-old Caucasian man with a 5-year history of untreated chronic lymphocytic leukemia who presented with Merkel cell carcinoma on the right gluteal region.
Darko Antic, Jelena Jelicic, Vojin Vukovic, Gordana Pupic, Zorka Milovanovic, Biljana Mihaljevic   +5 more
doaj   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Vulvar neuroendocrine carcinoma that is independent of merkel cell polyomavirus and human papillomavirus suggests endometrial cancer recurrence: a case report

BMC Endocrine Disorders, 2022
Background Vulvar neuroendocrine carcinomas with small cell morphology need an appropriate differential diagnosis with respect to primary Merkel cell carcinomas, primary small cell neuroendocrine carcinomas, and secondary/metastatic carcinomas.
Tomoko Hirakawa, Mitsutake Yano, Haruto Nishida, Shimpei Sato, Kaei Nasu   +4 more
doaj   +1 more source

Merkel cell carcinoma and sarcoidosis — an association like no other

Oncology in Clinical Practice
The association between Merkel cell carcinoma of unknown origin and sarcoidosis is rarely documented, pos­ing a significant challenge in distinguishing between these two conditions with drastically different prognoses.
Maaroufi Abdelkhaleq, Benameur Yasser, Essaoudi Amine Mohamed, Fatihi Jamal   +3 more
doaj   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source