Results 51 to 60 of about 16,548 (197)

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity [PDF]

, 2022
As an essential component of mechano-gated ion channels, critically required for mechanotransduction in mammalian cells, PIEZO2 is known to be characteristically expressed by Merkel cells in human skin.
Martín Sanz, Raquel, García-Suárez, Olivia, García Mesa, Yolanda, Cobo, Ramón, Benjamín Martín-Biedma, Vega, José Antonio, Jorge Feito, Feito Pérez, Jorge, Feito, Jorge, García-Mesa, Yolanda, Vega Álvarez, José Antonio, García Suárez, Olivia, Martín-Biedma, Benjamín, Yolanda García-Mesa, Martín Biedma, B., Martín-Sanz, Raquel, Cobo Díaz, Ramón, Jorge García-Piqueras, Saray Muñoz-Bravo, Olivia García-Suárez, Muñoz-Bravo, Saray, Raquel Martín-Sanz, García-Piqueras, Jorge, García Piqueras, Jorge, Ramón Cobo, Muñoz Bravo, Saray, José Antonio Vega   +26 more
core   +1 more source

Merkel-Cell Carcinoma

New England Journal of Medicine
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that is highly radiosensitive and immunogenic. Immunotherapy is the primary treatment of advanced disease, and immune checkpoint inhibitors show promise as neoadjuvant or adjuvant therapy in patients with high-risk resectable MCC.
Zunaid Ahmed, Willem Visser
  +8 more sources

Concomitant chronic lymphocytic leukemia and Merkel cell carcinoma

Dermatologica Sinica, 2015
We present the case of a 69-year-old Caucasian man with a 5-year history of untreated chronic lymphocytic leukemia who presented with Merkel cell carcinoma on the right gluteal region.
Darko Antic, Jelena Jelicic, Vojin Vukovic, Gordana Pupic, Zorka Milovanovic, Biljana Mihaljevic   +5 more
doaj   +1 more source

The 9th Edition of the UICC TNM Classification of Malignant Tumours: Updates and Rationale for Change

International Journal of Cancer, EarlyView.
ABSTRACT The standard for assessing and recording the extent of the tumour, a necessity for most malignancies, is the Tumour Node Metastases (TNM) classification. The Union for International Cancer Control (UICC) TNM committee has defined this since the early 1950s.
James D. Brierley, Liesbet J. Van Eycken, Meredith E. Giuliani, Brian A. Rous, Shao Hui Huang, Hisao Asamura, Mary K. Gospodarowicz, Anne W. Lee, Brian O'Sullivan   +8 more
wiley   +1 more source

Vulvar neuroendocrine carcinoma that is independent of merkel cell polyomavirus and human papillomavirus suggests endometrial cancer recurrence: a case report

BMC Endocrine Disorders, 2022
Background Vulvar neuroendocrine carcinomas with small cell morphology need an appropriate differential diagnosis with respect to primary Merkel cell carcinomas, primary small cell neuroendocrine carcinomas, and secondary/metastatic carcinomas.
Tomoko Hirakawa, Mitsutake Yano, Haruto Nishida, Shimpei Sato, Kaei Nasu   +4 more
doaj   +1 more source

Replication Data for: Comparative and integrated analyses of polyomavirus-negative and -positive Merkel cell carcinoma cell lines and their exosomes proteomic studies

, 2019
This dataset is analyses of identified proteins between MCPyV-negative (MCC13, MCC26, and UISO) and -positive (MKL1, MKL2, MS1, and WaGa) MCC cell line.Abstract: Proteomics have become an important tool in discovery and understanding pathological ...
Konstantinell, Aelita Gloria Virginia
core   +1 more source

Merkel cell carcinoma and sarcoidosis — an association like no other

Oncology in Clinical Practice
The association between Merkel cell carcinoma of unknown origin and sarcoidosis is rarely documented, pos­ing a significant challenge in distinguishing between these two conditions with drastically different prognoses.
Maaroufi Abdelkhaleq, Benameur Yasser, Essaoudi Amine Mohamed, Fatihi Jamal   +3 more
doaj   +1 more source

Risk Factors for Cutaneous Immune‐Related Adverse Events in the Japanese Population: A Retrospective Single‐Center Cohort Study

The Journal of Dermatology, EarlyView.
ABSTRACT Immune checkpoint inhibitor (ICI)‐driven alterations in the immune system can induce immune‐related adverse events (irAEs). Cutaneous irAEs are notable for being the most common and for their early onset; however, the risk factors underlying their development and severity remain unclear. In this study, we retrospectively analyzed 1224 Japanese
Tomoya Watanabe, Kohei Yamakawa, Miyu Kobayashi, Yusuke Saigusa, Yukie Yamaguchi   +4 more
wiley   +1 more source

Merkel Cell Carcinoma [PDF]

American Journal of Clinical Oncology, 2013
Merkel cell carcinoma (MCC) is a rare, clinically aggressive cutaneous neuroendocrine neoplasm with a high mortality rate. Though the etiology is not precisely known, Merkel cell polyomavirus DNA has been found recently in a large percentage of MCC tumors.
Emma, Ramahi, Jehee, Choi, Clifton D, Fuller, Tony Y, Eng   +3 more
openaire   +2 more sources