Results 71 to 80 of about 361,742 (335)

Primary Transitional Cell Carcinoma of the Fallopian Tube [PDF]

, 2012
Primary carcinoma of the fallopian tube is a rare entity that accounts for 0.2-0.5% of all gynecologic malignancies, and most are discovered during or after surgery.
Kaushal, V, Mardi, K
core   +1 more source

The Challenges and Opportunities of lncRNAs in Ovarian Cancer Research and Clinical Use [PDF]

, 2020
[Abstract] Ovarian cancer is one of the most lethal gynecological malignancies worldwide because it tends to be detected late, when the disease has already spread, and prognosis is poor.
Barreiro-Alonso, Aida, Cerdán, María Esperanza, Lamas, Mónica, Quindós-Varela, María, Rodríguez-Belmonte, Esther, Salamini-Montemurri, Martín, Vizoso-Vázquez, Ángel   +6 more
core   +1 more source

The Involvement of RhoA and Wnt-5a in the Tumorigenesis and Progression of Ovarian Epithelial Carcinoma

International Journal of Molecular Sciences, 2013
Background Ras homolog gene family member A (RhoA) is involved in Wnt-5a–induced migration of gastric and breast cancer cells. We investigated the roles of RhoA and Wnt-5a in ovarian carcinoma.
Shuo Chen, Jun Wang, Wen-feng Gou, Yin-ling Xiu, Hua-Chuan Zheng, Z. Zong, Y. Takano, Yang Zhao   +7 more
semanticscholar   +1 more source

Role of Farletuzumab in Epithelial Ovarian Carcinoma [PDF]

Current Pharmaceutical Design, 2012
Epithelial ovarian cancer (EOC) is the most lethal of the gynecologic malignancies, largely due to the advanced stage at diagnosis in most patients. Standard treatment for EOC is surgical debulking followed by platinum-based chemotherapy. While the majority of ovarian cancer patients will respond to initial chemotherapy, most will ultimately relapse ...
Danijela, Jelovac, Deborah K, Armstrong
openaire   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The neuroepithelial origin of ovarian carcinomas explained through an epithelial-mesenchymal-ectodermal transition enhanced by cisplatin

Scientific Reports
Acquired resistance to platinum-derived cytostatics poses major challenges in ovarian carcinoma therapy. In this work, we show a shift in the epithelial-mesenchymal transition (EMT) process towards an “ectodermal” conversion of ovarian carcinoma cells in
David Díaz-Carballo, Ayesha Safoor, Sahitya Saka, Adrien Noa-Bolaño, Flevy D’Souza, Jacqueline Klein, Ali H. Acikelli, Sascha Malak, Udo Rahner, Amin T. Turki, Anne Höppner, Annabelle Kamitz, Wanlu Song, Ye-guang Chen, Lalitha Kamada, Andrea Tannapfel, Sebastian Brinkmann, Crista Ochsenfarth, Dirk Strumberg   +18 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Testicular serous carcinoma of ovarian epithelial type

Journal of Cancer Research and Practice, 2017
Epithelial tumor has been the most common group of ovarian neoplasia found in women. Ovarian epithelial tumors are extremely rare in the testicular and para-testicular tissue of men, though benign, borderline and malignant neoplasia have been reported.1 ...
Chang-Hong Yeh, Pin-Pen Hsieh, Shyh-Jer Lin, Ying-Chung Hong, Tsung-Hsien Tsai, Lennex Hsueh-Lin Yu, Ming-Sun Yu   +6 more
doaj   +1 more source

Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma*

Journal of Biological Chemistry, 2015
Background: Aberrant activation of Wnt/β-catenin signaling is found in ovarian cancer, even when mutations are absent. Results: The bioactive lipid lysophosphatidic acid induces β1-integrin clustering, nuclear β-catenin translocation, and activation of ...
Rebecca J. Burkhalter, S. Westfall, Yueying Liu, M. Stack   +3 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source