Results 141 to 150 of about 357,374 (264)

Total Chemical Synthesis of Interleukin‐15 and Interleukin‐2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy

Angewandte Chemie, EarlyView.
A reducible solubilizing tag strategy (RST‐2.0) enables the synthesis, purification and ligation of difficult peptides while being readily removable just during folding, which overcomes the common challenges from protein hydrophobicity and aggregation. With this method, we achieved the first total synthesis of native and N‐glycosylated IL‐15 as well as
Jingwen Zeng, Haiyan Zhou, Wang Xia, Hongxiang Wu, Xuechen Li   +4 more
wiley   +2 more sources

TRIM2 downregulation in clear cell renal cell carcinoma affects cell proliferation, migration, and invasion and predicts poor patients’ survival

, 2018
Wen Xiao, Xuegang Wang, Tao Wang, Jinchun Xing Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China Background and aim: Tripartite motif containing (TRIM) family protein has been involved in multiple ...
Xing J, Wang T, Xiao W, Wang X
core  

guichengpeng1/WSI-based-deep-learning-classifier-in-papillary-renal-cell-carcinoma: WSI-based deep learning classifier in papillary renal cell carcinoma

<p>Deep learning for predicting recurrence in papillary renal cell carcinoma.</p> <p>The model was built around multiple instance learning and comprised a MobileNet V3 representation network, a Noisy-AND pooling function, and a fully ...
Chengpeng Gui, huangkb1005
core   +1 more source

Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease

American Journal of Hematology, EarlyView.
ABSTRACT Chronic antigenic stimulation is implicated in the pathogenesis of monoclonal gammopathy and multiple myeloma, yet longitudinal human evidence linking sustained antigen exposure to modifiable clonal plasma cell evolution remains limited. Gaucher disease (GD), caused by biallelic GBA1 pathogenic variants, is characterized by accumulation of ...
Noor Ul Ain, Noffar Bar, Lilu Guo, Katherine Klinger, Punita Gupta, Atta Ur Rahman, Ruhua Yang, Yanhong Deng, Natalia Neparidze, Shiny Nair, Pramod K. Mistry   +10 more
wiley   +1 more source

Renal cell carcinoma: links and risks

, 2016
Reena Kabaria, Zachary Klaassen, Martha K Terris Department of Surgery, Section of Urology, Augusta University, Augusta, GA, USA Abstract: This review provides an overview of the incidence of renal cell carcinoma (RCC) and a summary of the most commonly
Terris MK, Klaassen Z, Kabaria R
core  

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Development of Sub‐50 nm Core–Shell Silica Nanoparticles With Controlled In Vivo Behavior for 19F Magnetic Resonance Imaging

Angewandte Chemie, EarlyView.
Ultrasmall PFCE‐loaded silica nanoparticles synthesized through a one‐pot double‐emulsion synthesis method, where rapid silica shell formation kinetically fixes droplet size. The resulting s‐FLAME nanoparticles enable strong 19F MRI signals with enhanced hepatic clearance rate and tumor‐accumulation performance. ABSTRACT 19F magnetic resonance imaging (
Yue Wu, Masafumi Minoshima, Kazuya Kikuchi   +2 more
wiley   +2 more sources

Proliferative behaviour and cytogenetic changes in human renal-cell carcinoma [PDF]

, 1991
Werner, M., Stief, Christian Georg, Riese, W. de, Azpodien, J., Kirchner, H., Jonas, Udo, Allhoff, E. P., Djamilian, Mohamad H., Schlick, R. W.   +8 more
core   +1 more source

Proteomic profiling of urinary proteins in renal cancer by surface enhanced laser desorption ionisation (SELDI) and neural-network analysis: Identification of key issues affecting potential clinical utility.

, 2003
Recent advances in proteomic profiling technologies, such as surface enhanced laser desorption ionization mass spectrometry, have allowed preliminary profiling and identification of tumor markers in biological fluids in several cancer types and ...
Rogers, M. A., Noble, Jason, Clarke, Paul, Selby, P. J., Banks, R. E., Munro, N. P., Paul, A.   +6 more
core  

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source