Results 91 to 100 of about 2,761,482 (311)

The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism

Advanced Science, EarlyView.
Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang, Yi Xie, Shenglong Xia, Xinnuo Ge, Jiaying Li, Fang Liu, Fan Jia, Shengyao Wang, Qiao Zhou, Menghan Gao, Weihuan Fang, Chao Zheng   +11 more
wiley   +1 more source

Predictive capacity of a miRNA panel in identifying teratoma in post‐chemotherapy consolidation surgeries

BJUI Compass, Volume 4, Issue 1, Page 81-87, January 2023., 2023
Abstract Objectives To investigate the utility of a novel serum miRNA biomarker panel to distinguish teratoma from nonmalignant necrotic/fibrotic tissues or nonviable tumours in patients with NSGCT undergoing post‐chemotherapy consolidation surgery.
Joseph A. Moore, Michael J. Lehner, Simone Anfossi, Saumil Datar, Rebecca S. Tidwell, Matthew Campbell, Amishi Y. Shah, John F. Ward, Jose A. Karam, Christopher G. Wood, Lois L. Pisters, George A. Calin, Shi‐Ming Tu   +12 more
wiley   +1 more source

Coincidence of Inflamed Conjunctival Carcinoma in situ and Primary Pterygium

Case Reports in Ophthalmology, 2016
Background: We report a rare case of carcinoma in situ (CIS) in conjunction with a primary pterygium that exhibited characteristic angiographic and histopathological findings.
H. Endo, S. Kase, Yasuo Suzuki, M. Kase
semanticscholar   +1 more source

Adverse surgical outcomes in screen-detected ductal carcinoma in situ of the breast [PDF]

, 2014
Background: The Sloane Project is the largest prospective audit of ductal carcinoma in situ (DCIS) worldwide, with over 12000 patients registered between 2003 and 2012, accounting for 50% of screen-detected DCIS diagnosed in the UK over the period of ...
,, Ball, Graham, Clements, Karen, Dobson, Hilary, Evans, Andrew, Hanby, Andrew, Lawrence, Gill, Maxwell, Anthony, Pinder, Sarah E, Thomas, Jeremy, Thompson, Alastair, Wallis, Matthew   +11 more
core   +1 more source

Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis

Advanced Science, EarlyView.
This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Xiaoyun Cao, Yang Hu, Kai Yan Cheng, Hui Li, Yang Ji, Yan Liu, Matthew Ackers‐Johnson, Roger S.Y. Foo, Yujia Shen, Haojie Yu   +13 more
wiley   +1 more source

Verteporfin‐Mediated In Situ Nanovaccine Based on Local Conventional‐Dose Hypofractionated Radiotherapy Enhances Antitumor and Immunomodulatory Effect

Advanced Science, EarlyView.
Here gelatinase‐responsive methoxypolyethyleneglycol–PVGLIG–polycaprolactone (mPEG–PVGLIG–PCL) nanoparticles’ loading verteporfin (N@VP) is developed, enhancing radiotherapy via X‐ray‐triggered singlet oxygen generation. Combined with 2 Gy (gray, a radiation dose unit) irradiation, N@VP achieves antitumor efficacy comparable to 8 Gy, and also promotes ...
Zhifan Zhang, Lin Li, Yuchen Ge, Anni Chen, Shanchao Diao, Yueling Yang, Qianyue Chen, Yingling Zhou, Jie Shao, Fanyan Meng, Lixia Yu, Manman Tian, Xiaoping Qian, Zhaoyu Lin, Chen Xie, Baorui Liu, Rutian Li   +16 more
wiley   +1 more source

Clinical-pathological features of an occult mixed mucinous male breast cancer. a case report [PDF]

, 2017
Mucinous carcinoma of the male breast is an uncommon malignant breast neoplasm and its diagnoses remain difficult. It is probably due to such a low rate of breast cancer cases that men tend to be diagnosed at an older age than women and with a later ...
Bonifacino, Adriana, Carico, Elisabetta, Giarnieri, Enrico, Giovagnoli, Maria Rosaria, Lamberti, Ilaria, Mancini, Rita, Scarpino, Stefania, Villani, Sandra   +7 more
core   +1 more source

LincNEAT1 Encoded‐NEAT1‐31 Promotes Phagocytosis by Directly Activating the Aurora‐A–PI3K–AKT Pathway

Advanced Science, EarlyView.
LincNEAT1 Encoded‐NEAT1‐31 micropeptide directly binds with Aurora‐A and enhanced AKT pathways to pormotes phagocytosis against multi cancer cells. Abstract Macrophages play vital roles in innate and adaptive immunity, and their essential functions are mediated by phagocytosis and antigen presentation.
Jie Li, Jing Zhang, Xixi Li, Xin Liu, Bo Zeng, Jiayue Luo, Huijin Wang, Hanbing Zhang, Xinya Gao   +8 more
wiley   +1 more source

Molecular drivers of lobular carcinoma in situ

Breast Cancer Research, 2015
Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular carcinoma (ILC).
G. Logan, D. Dabbs, P. C. Lucas, R. Jankowitz, Daniel D Brown, B. Clark, S. Oesterreich, P. McAuliffe   +7 more
semanticscholar   +1 more source

Can high-frequency ultrasound predict metastatic lymph nodes in patients with invasive breast cancer? [PDF]

, 2004
Aim To determine whether high-frequency ultrasound can predict the presence of metastatic axillary lymph nodes, with a high specificity and positive predictive value, in patients with invasive breast cancer.
Clough, G.R., Haigh, L.I.G., Truscott, J.   +2 more
core   +2 more sources