Results 71 to 80 of about 4,585,967 (340)

Regulation of Cardiomyocyte Mechanotransduction by the Cardiac Cycle [PDF]

Circulation, 2001
Background —Overloading the left ventricle in systole (pressure overload) is associated with a distinct morphological response compared with overload in diastole (volume overload). Methods and Results —We designed a novel computer-controlled experimental system that interfaces ...
Hayden Huang, Yoshikazu Maeda, Quynh N. Dang, Ralph A. Kelly, Keiji Yamamoto, Richard T. Lee   +5 more
openaire   +3 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Modeling 3D cardiac contraction and relaxation with point cloud deformation networks [PDF]

arXiv, 2023
Global single-valued biomarkers of cardiac function typically used in clinical practice, such as ejection fraction, provide limited insight on the true 3D cardiac deformation process and hence, limit the understanding of both healthy and pathological cardiac mechanics.
arxiv  

The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]

, 2017
Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena, Dal Sasso, Eleonora, Forte, Maurizio, Frati, Giacomo, Gerosa, Gino, Iop, Laura, Palmerio, Silvia, Peruzzi, Mariangela, Schirone, Leonardo, Sciarretta, Sebastiano   +9 more
core   +4 more sources

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Spatio-temporal Multi-task Learning for Cardiac MRI Left Ventricle Quantification [PDF]

, 2020
Quantitative assessment of cardiac left ventricle (LV) morphology is essential to assess cardiac function and improve the diagnosis of different cardiovascular diseases. In current clinical practice, LV quantification depends on the measurement of myocardial shape indices, which is usually achieved by manual contouring of the endo- and epicardial ...
arxiv   +1 more source

Considering the role of Murine double minute 2 in the cardiovascular system [PDF]

, 2019
The E3 ubiquitin ligase Murine double minute 2 (MDM2) is the main negative regulator of the tumor protein p53 (TP53). Extensive studies over more than two decades have confirmed MDM2 oncogenic role through mechanisms both TP53-dependent and TP53 ...
Lam, Brian, Roudier, Emile
core   +1 more source

Electrokymographic Studies of the Normal Cardiac Cycle [PDF]

Circulation, 1950
Normal subjects were studied by employing two electrokymograms simultaneously. By comparing the sequence of events in the carotid pulse, auricle and ventricle, measurements were made of the phases of the cardiac cycle. The normal electrokymogram is discussed and illustrated.
Philip Samet, Henry Mednick, John B. Schwedel   +2 more
openaire   +3 more sources

Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration

Circulation, 2020
Supplemental Digital Content is available in the text. Background: The adult mammalian heart has limited regenerative capacity, mostly attributable to postnatal cardiomyocyte cell cycle arrest.
Ajit Magadum, Neha Singh, Ann Anu Kurian, I. Munir, Talha Mehmood, Kemar J Brown, M. Sharkar, E. Chepurko, Y. Sassi, J. Oh, Philyoung Lee, Celio X. C. Santos, Avital Gaziel-Sovran, Guoan Zhang, C. Cai, C. Kho, M. Mayr, A. Shah, R. Hajjar, L. Zangi   +19 more
semanticscholar   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source