Results 71 to 80 of about 577,063 (338)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Epigenetic regulation of cardiac myocyte differentiation

Frontiers in Genetics, 2014
Cardiac myocytes proliferate robustly during fetal life but withdraw permanently from the cell cycle soon after birth and undergo terminal differentiation.
Kyohei eOyama, Danny eEl-Nachef, Yiqiang eZhang, Patima eSdek, William Robb Maclellan   +4 more
doaj   +1 more source

Mitochondrial Deformation During the Cardiac Mechanical Cycle [PDF]

The Anatomical Record, 2018
ABSTRACTCardiomyocytes both cause and experience continual cyclic deformation. The exact effects of this deformation on the properties of intracellular organelles are not well characterized, although they are likely to be relevant for cardiomyocyte responses to active and passive changes in their mechanical environment.
E. A. Rog‐Zielinska, E. T. O'Toole, A. Hoenger, P. Kohl   +3 more
openaire   +4 more sources

Including Aortic Valve Morphology in Computational Fluid Dynamics Simulations: Initial Findings and Application to Aortic Coarctation [PDF]

, 2012
Computational fluid dynamics (CFD) simulations quantifying thoracic aortic flow patterns have not included disturbances from the aortic valve (AoV). 80% of patients with aortic coarctation (CoA) have a bicuspid aortic valve (BAV) which may cause adverse ...
Cava, Joseph Richard, Ellwein, Laura M, Gandy, Kimberly L., Krolikowski, Mary M., LaDisa, John F., Pelech, Andrew N., Samyn, Margaret M., Shadden, Shawn C., Wendell, David C.   +8 more
core   +2 more sources

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Visualizing the Cardiac Cycle: A Useful Tool to Promote Student Understanding

Journal of Microbiology & Biology Education, 2011
The cardiac cycle is an important concept presented in human anatomy and physiology courses. At Kingsborough Community College, all Allied Health majors taking Anatomy & Physiology must understand the cardiac cycle to grasp more advanced concepts ...
Ivan Shun Ho
doaj   +1 more source

Epigenetic Reader Bromodomain Containing Protein 2 Facilitates Pathological Cardiac Hypertrophy via Regulating the Expression of Citrate Cycle Genes

Frontiers in Pharmacology, 2022
The bromodomain and extra-terminal domain proteins (BETs) family serve as epigenetic “readers”, which recognize the acetylated histones and recruit transcriptional regulator complexes to chromatin, eventually regulating gene transcription.
Zhirong Lin, Zhenzhen Li, Zhen Guo, Yanjun Cao, Jingyan Li, Peiqing Liu, Zhuoming Li   +6 more
doaj   +1 more source

Multiresolution spatiotemporal mechanical model of the heart as a prior to constrain the solution for 4D models of the heart. [PDF]

, 2019
In several nuclear cardiac imaging applications (SPECT and PET), images are formed by reconstructing tomographic data using an iterative reconstruction algorithm with corrections for physical factors involved in the imaging detection process and with ...
Gullberg, Grant T, Liu, Jing, Ordovas, Karen, Segars, W Paul, Seo, Youngho, Shrestha, Uttam M, Veress, Alexander I   +6 more
core   +2 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

A pseudo active kinematic constraint for a biological living soft tissue: an effect of the collagen network [PDF]

, 2008
Recent studies in mammalian hearts show that left ventricular wall thickening is an important mechanism for systolic ejection and that during contraction the cardiac muscle develops significant stresses in the muscular cross-fiber direction. We suggested
Bourdarias, Christian, Gerbi, Stéphane, Ohayon, Jacques   +2 more
core   +4 more sources