Results 41 to 50 of about 145,404 (307)

Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality? [PDF]

, 2016
Systemic Sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and multiple internal organs and severe functional and structural microvascular alterations.
Jimenez, Sergio A., Piera-Velazquez, Sonsoles   +1 more
core   +2 more sources

Anti-fibrotic Effects of Cardiac Progenitor Cells in a 3D-Model of Human Cardiac Fibrosis

Frontiers in Cardiovascular Medicine, 2019
Cardiac fibroblasts play a key role in chronic heart failure. The conversion from cardiac fibroblast to myofibroblast as a result of cardiac injury, will lead to excessive matrix deposition and a perpetuation of pro-fibrotic signaling.
Tom C. L. Bracco Gartner, Tom C. L. Bracco Gartner, Tom C. L. Bracco Gartner, Tom C. L. Bracco Gartner, Janine C. Deddens, Janine C. Deddens, Emma A. Mol, Emma A. Mol, Marina Magin Ferrer, Linda W. van Laake, Linda W. van Laake, Linda W. van Laake, Carlijn V. C. Bouten, Ali Khademhosseini, Pieter A. Doevendans, Pieter A. Doevendans, Pieter A. Doevendans, Pieter A. Doevendans, Pieter A. Doevendans, Pieter A. Doevendans, Willem J. L. Suyker, Willem J. L. Suyker, Willem J. L. Suyker, Joost P. G. Sluijter, Joost P. G. Sluijter, Joost P. G. Sluijter, Jesper Hjortnaes, Jesper Hjortnaes, Jesper Hjortnaes   +28 more
doaj   +1 more source

Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis

eLife, 2020
Intermittent hypoxia (IH) is the predominant pathophysiological disturbance in obstructive sleep apnea (OSA), known to be independently associated with cardiovascular diseases.
Qiankun Bao, Bangying Zhang, Ya Suo, Chen Liu, Qian Yang, Kai Zhang, Ming Yuan, Meng Yuan, Yue Zhang, Guangping Li   +9 more
doaj   +1 more source

GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]

, 2013
Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Andras Dinnyes, Csilla Nemes, Eszter Varga, Jalving M., Melinda K. Pirity, Nuttha Klincumhom, Zsuzsanna Polgar   +6 more
core   +1 more source

In vitro effects of pirfenidone on cardiac fibroblasts: proliferation, myofibroblast differentiation, migration and cytokine secretion.

PLoS ONE, 2011
Cardiac fibroblasts (CFs) are the primary cell type responsible for cardiac fibrosis during pathological myocardial remodeling. Several studies have illustrated that pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) attenuates cardiac fibrosis in different
Qiang Shi, Xiaoyan Liu, Yuanyuan Bai, Chuanjue Cui, Jun Li, Yishi Li, Shengshou Hu, Yingjie Wei   +7 more
doaj   +1 more source

Silencing of UTX Mitigates Aging-Associated Cardiac Fibrosis via Blocking Cardiac Fibro blaststo-Myofibroblasts Trans-Differentiation

Anatolian Journal of Cardiology, 2023
Background: Cardiac fibrosis increases with age. Fibroblast activation plays an essential role in cardiac fibrosis. Histone modifications are involved in various chromatin-dependent processes.
Chao Li, Tiantian Lin, Delin Li, Daoyuan Si, Huan Sun, Sibao Yang, Zhongfan Zhang, Qian Zhang, Kaiyao Shi   +8 more
doaj   +1 more source

Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1

Redox Biology
Cardiac fibrosis remains an unresolved clinical issue in patients with heart diseases. CircRNAs have emerged as potential targets for treatment of heart diseases.
Yan Chen, Zhewei Zhang, Yue Cheng, Xiaofeng Chen, Junteng Zhou, Zisong Wei, Han Yao, Shuwen Zhang, Qihang Kong, Hao Tang, Wenchao Wu, Zhichao Zhou, Xiaoqiang Tang, Xiaojing Liu   +13 more
doaj   +1 more source

Association of Tenofovir Use With Risk of Incident Heart Failure in HIV-Infected Patients. [PDF]

, 2017
BackgroundThe antiretroviral medication, tenofovir disoproxil fumarate (TDF), is used by most human immunodeficiency virus-infected persons in the United States despite higher risks of chronic kidney disease.
Chen, Ruijun, Estrella, Michelle M, Grunfeld, Carl, Horberg, Michael A, Hsue, Priscilla Y, Jotwani, Vasantha, Scherzer, Rebecca, Shlipak, Michael G   +7 more
core   +1 more source

Integrins, Focal Adhesions, and Cardiac Fibroblasts [PDF]

Journal of Investigative Medicine, 2009
How the myocardium undergoes geometric, structural, and molecular alterations that result in an end phenotype as might be seen in patients with dilated cardiomyopathy or after myocardial infarction is still poorly understood. Structural modification of the left ventricle, which occurs during these pathological states, results from long-term changes in
Ana Maria, Manso, Seok-Min, Kang, Robert S, Ross   +2 more
openaire   +2 more sources

Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: A mechanism underlying RV fibrosis associated with cigarette smoke exposure [PDF]

, 2017
INTRODUCTION: Right ventricular dysfunction is associated with numerous smoking-related illnesses including chronic obstructive pulmonary disease (COPD) where it is present even in absence of pulmonary hypertension. It is unknown if exposure to cigarette
Allawzi, Ayed, Chichger, Havovi, Choudhary, Gaurav, Clements, Richard T., Dudley, Samuel C. Jr., Jeong, Euy-Myoung, Kue, Nouaying, Lu, Qing, O'Connell, Kelly, Rounds, Sharon, Sakhatskyy, Pavlo, Vang, Alexander, Zhang, Peng   +12 more
core   +1 more source