Results 121 to 130 of about 182,384 (307)

Patient‐Derived 3D Bioprinted Cardiac Organoid Constructs Reveal Key Pathological Features of Duchenne Muscular Dystrophy

Advanced Healthcare Materials, EarlyView.
Patient‐derived cardiac organoids reveal key features of Duchenne muscular dystrophy cardiomyopathy, including apoptosis, oxidative stress, calcium handling defects, and mechanical remodeling. By integrating organoids into alginate–gelatin bioprinted constructs, disease phenotypes are organized into scalable 3D cardiac tissues displaying extracellular ...
Vittoria Marini, Margalida Campaner Socias, Andreas Dimopoulos, Lorenza Rinvenuto, Enrico Pozzo, Diana Stalkopf, Angelo Serafini, Sara Morri, Ashley Wang, Rita La Rovere, Yoke Chin Chai, Sveva Bollini, Geert Bultynck, H. Llewelyn Roderick, Ioannis Papantoniou, Maurilio Sampaolesi   +15 more
wiley   +1 more source

Long QT syndrome type 3 gain-of-function of Nav1.5 increases ventricular fibroblasts proliferation and pro-fibrotic factors

Communications Biology
The long QT syndrome type 3 (LQT3) is a cardiac channelopathy caused by gain-of-function mutations in the SCN5A gene, encoding the sodium channel Nav1.5.
Claire Castro, Justine Patin, Cyrielle Jajkiewicz, Franck Chizelle, Cynthia Ore Cerpa, Agnès Tessier, Eva Le Pogam, Imen Fellah, Isabelle Baró, Flavien Charpentier, Mickaël Derangeon   +10 more
doaj   +1 more source

Macrophage Migration Inhibitory Factor (MIF) Expression Increases during Myocardial Infarction and Supports Pro-Inflammatory Signaling in Cardiac Fibroblasts

Biomolecules, 2019
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine known to play a major role in inflammatory diseases such as myocardial infarction (MI), where its expression increases.
Svenja Voss, Saskia Krüger, Katharina Scherschel, Svenja Warnke, Michael Schwarzl, Benedikt Schrage, Evaldas Girdauskas, Christian Meyer, Stefan Blankenberg, Dirk Westermann, Diana Lindner   +10 more
doaj   +1 more source

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

SALL4 mediates SHP2 inhibition in myocardial fibroblasts through the DOT1L/H3K79me2 signaling pathway to promote the progression of myocardial infarction

Scientific Reports
Objective: To explore the influence of SALL4 in cardiac fibroblasts on the progression of myocardial infarction. Methods: Analysis of genes specifically expressed in myocardial infarction by bioinformatics methods; The impact of SALL4 on myocardial ...
Yanhong Zong, Ming Zhao, Zhipeng Tang, Yanqing Tie, Kenan Peng, He Tan   +5 more
doaj   +1 more source

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice [PDF]

, 2017
Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive ...
Birnbaumer, Lutz, Harada, Eri, Ishikawa, Tatsuya, Kitajima, Naoyuki, Kumagai, Yoshito, Nishida, Motohiro, Nishimura, Akiyuki, Numaga Tomita, Takuro, Oda, Sayaka, Shimauchi, Tsukasa, Tomizaki, Takashi   +10 more
core   +1 more source

A Versatile Engineering Platform for the Fabrication of Prosthetic Venous Valves Using Electrospinning

Advanced Healthcare Materials, EarlyView.
Percutaneous prosthetic venous valves are fabricated by embedding stents in an electrospun matrix that extends luminally to form leaflets. The design shields leaflets from hyperplastic cells, isolates struts from blood contact, and avoids discrete anchoring points.
Dario Arcuti, Salma Mansi, Dominic Biebl, Malin Reuter, Maximilian Grab, José Carlos Rodríguez‐Cabello, Petra Mela   +6 more
wiley   +1 more source

Direct Cardiac Reprogramming　― Converting Cardiac Fibroblasts to Cardiomyocytes ―

Circulation Reports, 2019
Cardiovascular disease is the leading cause of death and disability worldwide. Despite advances in cardiovascular therapy, mortality in heart disease still remains high. Direct cardiac reprogramming is a promising approach for cardiac tissue repair involving in situ generation of new cardiomyocytes from endogenous cardiac fibroblasts.
openaire   +3 more sources

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source