Results 171 to 180 of about 182,384 (307)

Editorial: Cardiac fibroblasts: from development to disease. [PDF]

Front Cell Dev Biol
Hernandez SC, Moore-Morris T, Ruiz-Villalba A.   +2 more
europepmc   +1 more source

Fibroblasts, myofibroblasts and cardiac arrhythmias

The Journal of Cardiovascular Aging, 2023
openaire   +2 more sources

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

Advanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie   +14 more
wiley   +1 more source

Single-cell and spatial transcriptomic profiling of cardiac fibroblasts following myocardial infarction. [PDF]

Sci Data
Hernández SC, Ainciburu M, Sudupe L, Planell N, López-Moreno M, Vilas-Zornoza A, Diaz-Martinez L, Cobos-Figueroa J, Romero JP, Sarvide S, San Martin-Uriz P, López-Pérez A, Abizanda G, Ripalda-Cemboráin P, Muinos-López E, Lagani V, Tegner J, Wu M, Janssens S, Pérez-Pomares JM, Prósper F, Ruiz-Villalba A, Gómez-Cabrero D.   +22 more
europepmc   +1 more source

TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6–GAS6 Axis

Advanced Science, EarlyView.
This study shows TGM2 is upregulated in AP, impairing macrophage efferocytosis by inhibiting the STAT6–GAS6 axis. The lactoferrin‐modified, ROS‐responsive LF‐LNP@si‐TGM2 targets pancreatic macrophages, silences TGM2, restores the axis, and alleviates AP.
Xuxu Liu, Zhiwei Du, Liyi Wang, Zhihong Xie, Ziang Meng, Yi Zheng, Heming Wang, Yuanhang He, Dongbo Xue   +8 more
wiley   +1 more source

Killing of Gold Nanorods-Loaded Human Cardiac Fibroblasts Mediated by Photo-Thermal Activation. [PDF]

ACS Omega
Floris E, Pompeo F, Picchio V, Miglietta S, De Mei V, Cozzolino C, Icolaro F, Petrozza V, Frati G, Petronella F, Chimenti I, Pagano F, De Sio L.   +12 more
europepmc   +1 more source

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, EarlyView.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source

Mechanical Stress Triggers Premature Senescence in Cardiac Fibroblasts. [PDF]

Adv Sci (Weinh)
Schneider SE, Scott AK, Gallagher KM, Miller EY, Ghosh S, Neu CP.   +5 more
europepmc   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension. [PDF]

Adv Sci (Weinh)
Wu LW, Chen M, Jiang CY, Jiang DJ, Zhang X, Xu XH, Liu YW, Feng B, Ye LC, He YY, Huang X, Zhang YC, Zhou XL, Shen Y, Liu TY, Fu LJ, Yan Y, Zhang H.   +17 more
europepmc   +1 more source