Results 201 to 210 of about 182,384 (307)

PFKM-Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation. [PDF]

Adv Sci (Weinh)
Fang N, Zhang N, Jiang X, Yan S, Wang Z, Gao Q, Xu M, Mu L, Li X, Chen J, Zhang S, Duan Y, Yun F, Li L, Zhang Y, Gong Y.   +15 more
europepmc   +1 more source

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

A secretome atlas of cardiac fibroblasts from healthy and infarcted mouse hearts. [PDF]

Commun Biol
Bahr J, Poschmann G, Jungmann A, Busch M, Ding Z, Vogt J, Zalfen R, Steinhausen J, Euan Martínez AA, Wachtmeister T, Rickert D, Lautwein T, Alter C, Amrute JM, Lavine KJ, Köhrer K, Levkau B, Most P, Stühler K, Hesse J, Schrader J.   +20 more
europepmc   +1 more source

Klhl31 is assocaited with skeletal myogenesis and its expression is regulated by myogenic signals and Myf-5 [PDF]

, 2009
Adams, Alaa Abou-Elhamd, Alvares, Andrea Münsterberg, Angers, Boardman, Borello, Bork, Borycki, Borycki, Borycki, Brent, Buckingham, Christ, Delfini, Dietrich, Dietrich, Fan, Geetha-Loganathan, Gros, Hamburger, Hara, Hollyday, Marcelle, McDermott, Münsterberg, Münsterberg, Oliver Cooper, Pownall, Pownall, Scaal, Schmidt, Schmidt, Schubert, Smith, Stogios, Stogios, Summerbell, Sweetman, Tajbakhsh, Wu, Xue, Yu   +42 more
core   +1 more source

The characteristics of collagen‐induced rheumatoid arthritis in macaques and the changes of heart

Animal Models and Experimental Medicine, EarlyView.
The disease progression in CIA macaques was categorized into three stages: IIR (days 14–34): The indicators related to rheumatoid arthritis and the levels of immunoglobulin were all elevated. There was a small amount of joint effusion, edema and mild synovial hyperplasia. No joint swelling was observed by naked eye.
Lei Zhang, Haifeng Jiang, Zhen Xu, Tingyu Dong, Xiaoyi Liu, Shangxue Yan, Jiajie Kuai, Yan Chang, Wei Wei   +8 more
wiley   +1 more source

Morphological and morphometric aspects of the equine aortic valve: New insights for comparative studies in mammals

The Anatomical Record, EarlyView.
Abstract New data on the equine aortic valve obtained using advanced techniques is especially important given the greater availability of animal models for translational research. Here we characterized the morphological and morphometric aspects of the equine aortic valve from 60 healthy hearts collected at equine abattoirs.
Vitor Pires Pereira, Victoria Brondani de Oliveira, Carlos Eduardo Seyfert, Luciano de Morais‐Pinto   +3 more
wiley   +1 more source

Molecular basis for Ca2+ channel diversity [PDF]

, 1994
Biel, Martin, Flockerzi, Veit, Hofmann, Franz   +2 more
core   +1 more source

Activated cardiac fibroblasts are a primary source of high-molecular-weight hyaluronan production. [PDF]

Am J Physiol Cell Physiol
Little DT, Howard CM, Pendergraft E, Brittian KR, Audam TN, Lukudu EW, Smith J, Nguyen D, Nishida Y, Yamaguchi Y, Brainard RE, Singhal RA, Jones SP.   +12 more
europepmc   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source