Results 91 to 100 of about 336,282 (259)

The orphan receptor GPR35 contributes to angiotensin II–induced hypertension and cardiac dysfunction in mice [PDF]

, 2018
BACKGROUND: The orphan receptor G protein–coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure.
Divorty, Nina, Graham, Delyth, Milligan, Graeme, Nicklin, Stuart A.   +3 more
core   +1 more source

Soft Ionic and Electronic Triboelectric Nanogenerators: Toward Attachable and Implantable Biomedical Applications

Advanced Materials, EarlyView.
This review provides an overview of triboelectric nanogenerator (TENG)–based biomedical applications by classifying studies into electronic and ionic systems across attachable and implantable platforms. It summarizes key material choices, device structures, and working mechanisms that characterize current TENG‐based research, and outlines six future ...
Kyongtae Choi, Jimin Park, Won Jun Song, Soohwan An, Seonggyu Choe, Byeong‐Rak Keum, Min Young Kim, Dae Hee Hwang, Young‐Geun Park, Sung‐Won Kim, Sangyul Baik, Gwang‐Bum Im, Younghoon Lee   +12 more
wiley   +1 more source

Gold Nanorods in Cardiac Millitissues: Assessing Mechanical and Contractile Dynamics in a Living Engineering Myocardium Model

Advanced Materials Technologies, EarlyView.
This study presents a novel platform for assessing the active mechanical behavior of living cardiac microbundles through localized nanoindentation, integrated with temperature regulation and dual‐camera imaging systems. The developed system enables quantitative evaluation of dynamic micromechanics in engineered cardiac tissues in vitro, offering ...
Lihua Lou, Lia Paolino, Alberto Sesena Rubfiaro, Jin He, Arvind Agarwal   +4 more
wiley   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceuticals

Animal Models and Experimental Medicine
Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fibrosis, which appears to be a leading cause of cardiovascular diseases.
Lujain Bader Eddin, Mohamed Fizur Nagoor Meeran, Niraj Kumar Jha, Samer N. Goyal, Shreesh Ojha   +4 more
doaj   +1 more source

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. [PDF]

, 2018
Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains unknown.
Aguirre, Aitor, Chen, Haodong, Chour, Tony, Holmström, Alexandra, Itzhaki, Ilanit, Jain, Mohit, Kim, Youngkyun, Lehmann, Kim, Ndoye, Babacar C, Neofytou, Evgenios, Qin, Xulei, Shukla, Praveen, Wu, Joseph C, Xiao, Dan, Yang, Huaxiao, Zhang, Joe Z, Zhao, Mingtao, Zhao, Xin, Zhuge, Yan, Zimmermann, Wolfram-Hubertus   +19 more
core   +3 more sources

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Activation of AMPK Attenuated Cardiac Fibrosis by Inhibiting CDK2 via p21/p27 and miR-29 Family Pathways in Rats

Molecular Therapy: Nucleic Acids, 2017
Cardiac fibrosis is pathological damage associated with nearly all forms of heart disease. AMP-activated protein kinase (AMPK) is an evolutionary conserved energy-sensing enzyme.
Hanping Qi, Yan Liu, Shuzhi Li, Yunping Chen, Lei Li, Yonggang Cao, Mingyao E, Pilong Shi, Chao Song, Baiyan Li, Hongli Sun   +10 more
doaj   +1 more source

Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease. [PDF]

, 2016
OBJECTIVE: To examine whether lung endothelial cells (ECs) from patients with systemic sclerosis (SSc)-associated interstitial lung disease (ILD) express mesenchymal cell-specific proteins and gene transcripts, indicative of the occurrence of endothelial-
Arciniegas, Beon, Cooley, Del Galdo, Falke, Gabrielli, Gilbane, Good, Goumans, Hashimoto, Herzog, Herzog, Hinz, Hinz, Humphreys, Jimenez, Katsumoto, Kendall, Kramann, Lamouille, LeBleu, Li, Li, Marelli-Berg, Matucci-Cerinic, McAnulty, Medici, Meeteren, Nolan, Pattanaik, Piera-Velazquez, Piera-Velazquez, Poslethwaite, Ranchoux, Rieder, Strieter, Varga, Veraldi, Wells, Yoshimatsu, Zeisberg, Zeisberg   +41 more
core   +2 more sources

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source