Results 101 to 110 of about 1,567,002 (208)

The Cytotoxic Cardiac Glycoside (-)-Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets. [PDF]

J Nat Prod, 2023
Ren Y, Kaweesa EN, Tian L, Wu S, Sydara K, Xayvue M, Moore CE, Soejarto DD, Cheng X, Yu J, Burdette JE, Kinghorn AD.   +11 more
europepmc   +1 more source

Mechanisms of Lycium barbarum Treatment in Sepsis‐Induced Myocardial Injury: A Network Pharmacology and Experimental Validation Study

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
The chemical characterization of the LB extract confirmed the presence of polysaccharides and specific small‐molecule constituents (e.g., rutin, isoquercitrin). Network pharmacology analysis predicted that the bioactive components of LB were able to interact with core targets such as TP53, AKT1, and JUN, and molecular docking simulations suggested ...
Ruxin Liu, Chunxia Ma, Yujiao Tang, Xue Bai, Liting Yang, Yi Hu, Zesu Niu, Weiliang Xue, Ling Zhang, Mengfei Chen   +9 more
wiley   +1 more source

Cardiac Glycoside Oleandrin Suppresses EMT Ability in Endometrial Carcinoma Cells. [PDF]

Int J Mol Cell Med, 2023
Secer Celik F, Eroglu Gunes C, Kurar E.
europepmc   +1 more source

Morroniside Attenuates Doxorubicin‐Induced Cardiotoxicity by Activating the PI3K/AKT/Nrf2/HO‐1 Pathway to Inhibit Ferroptosis and Oxidative Stress

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Mor activates the PI3K/AKT pathway to promote Nrf2 nuclear translocation and HO‐1 expression, enhancing antioxidants, curbing Fe2+‐induced ROS/lipid peroxidation, suppressing ferroptosis, and alleviating Dox‐induced cardiotoxicity. ABSTRACT Cardiotoxicity induced by doxorubicin (Dox) significantly contributes to increased mortality among cancer ...
Zhi‐Hui Lin, Xing‐Yu Lin, Wen‐Jie Lu, Meng‐Qi Wu, Dong‐Yan Song, Rui‐Dong Cheng   +5 more
wiley   +1 more source

Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status. [PDF]

Cell Commun Signal, 2023
Poohadsuan J, O'Doherty GA, Owattanapanich W, Kungwankiattichai S, Rojanasakul Y, Issaragrisil S, Luanpitpong S.   +6 more
europepmc   +1 more source

Investigation of the Efficacy of Orientin in Streptozotocin‐Induced Type 1 Diabetes Model and Pancreatic Beta‐TC6 Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Orientin, a natural flavonoid, protects against streptozotocin‐induced pancreatic β‐cell damage by suppressing NF‐κB–mediated inflammation, restoring antioxidant defense (SOD, CAT, GSH), and inhibiting apoptotic (Bax/Bcl‐2, Caspase‐3/9) and pyroptotic (Caspase‐1, IL‐1β) cell death pathways in both an in vivo type 1 diabetes mouse model and Beta‐TC6 ...
Bengul Ozdemir Sarikaya, Seyit Ali Bingol   +1 more
wiley   +1 more source

Genome and Tissue‐Specific Transcriptome of the Tropical Milkweed (Asclepias curassavica)

Plant Direct
Tropical milkweed (Asclepias curassavica) serves as a host plant for monarch butterflies (Danaus plexippus) and other insect herbivores that can tolerate the abundant cardiac glycosides that are characteristic of this species.
Honglin Feng, Jing Zhang, Adrian F. Powell, Gretta L. Buttelmann, Lily Yang, Ethan Yan, Fumin Wang, Steven B. Broyles, Georg Jander, Susan R. Strickler   +9 more
doaj   +1 more source

Subcellular localization of enzymes involved in the biosynthesis of digoxin in Digitalis lanata

Frontiers in Plant Science
Digoxin is a cardiac glycoside derived from the foxglove plant Digitalis lanata and is widely prescribed for treating heart failure and atrial fibrillation.
Viviane Zeng, Emily Carroll, Devon Burnside, Zhen Q. Wang   +3 more
doaj   +1 more source

Transcriptome Profiling of Cardiac Glycoside Treatment Reveals EGR1 and Downstream Proteins of MAPK/ERK Signaling Pathway in Human Breast Cancer Cells. [PDF]

Int J Mol Sci, 2023
Pavithran H, Kumavath R, Ghosh P.
europepmc   +1 more source

Cardiovascular Diseases and Cancer: Convergent Proteostasis Networks at the Crossroads of Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
The disruption of proteostasis, encompassing the ubiquitin–proteasome system, autophagy, UPR/ER stress, and chaperone function, represents a fundamental mechanism shared by both cancer and cardiovascular diseases. While these pathways frequently facilitate tumor progression, they are crucial for maintaining proteostasis in cardiac tissue. Consequently,
Jacob Eli García Torres, Norbert Frey, Ashraf Yusuf Rangrez   +2 more
wiley   +1 more source