Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies
MedComm, Volume 7, Issue 10, October 2026.The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao +7 more
wiley +1 more source
UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells
, 2010 International audienceCardiac steroids are used to treat various diseases including congestive heart failure and cancer. The aim of this study was to investigate the anti-leukemic activity of UNBS1450, a semi-synthetic cardenolide belonging to the ...
Henry, Estelle +20 more
core +1 more source
The Cytotoxic Cardiac Glycoside (-)-Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets. [PDF]
J Nat Prod, 2023 Ren Y +11 more
europepmc +1 more source
Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments
MedComm, Volume 7, Issue 10, October 2026.Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma +9 more
wiley +1 more source
Cardiac glycoside binding sites in cultured heart muscle cells [PDF]
, 1984 Erdmann, E. +9 more
core +1 more source
Cardiac Glycoside Oleandrin Suppresses EMT Ability in Endometrial Carcinoma Cells. [PDF]
Int J Mol Cell Med, 2023 Secer Celik F, Eroglu Gunes C, Kurar E.
europepmc +1 more source
Advanced Glycation End Products: From Pathogenesis to Treatment
MedComm, Volume 7, Issue 10, October 2026.Therapeutic landscape of AGE‐targeted intervention. Schematic representation of intervention strategies targeting distinct stages of AGE biology. Upstream prevention aims to reduce exposure and formation through low‐AGE cooking, smoking cessation, glycemic control, and metabolic optimization.
Tak‐Ho Lo +7 more
wiley +1 more source
Use of cardiac glycosides and risk of glioma
, 2016 Cardiac glycosides induce apoptotic effects on glioma cells, but whether cardiac glycosides protect against risk for glioma is unknown. We therefore explored the relation between glycoside use and glioma risk using a large and validated database.
Meier, Christoph R. +13 more
core +1 more source
Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status. [PDF]
Cell Commun Signal, 2023 Poohadsuan J +6 more
europepmc +1 more source
Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2405-2418, October 2026.Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider +3 more
wiley +1 more source