Results 101 to 110 of about 20,846 (206)

Higher sensitivity to ouabain‐induced toxicity in human induced pluripotent stem cell‐derived cardiomyocytes than human adult heart tissue despite similar Na+/K+‐ATPase pump current amplitudes

British Journal of Pharmacology, Volume 183, Issue 11, Page 3093-3110, June 2026.
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili, Paavo Virtanen, Junsoo Im, Paul Brunnbauer, Umber Saleem, Muhammed Ikbal Sönmez, Carl Schulz, Margaret Nandudu, Joris Winters, Cristina E. Molina, Johannes Petersen, Monika Stoll, Ulrich Schotten, Arne Hansen, Thomas Eschenhagen, Jussi T. Koivumäki, Torsten Christ   +16 more
wiley   +1 more source

Avaliação da ação citotóxica de cardenolídeos em células tumorais [PDF]

, 2015
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.Os cardenolídeos, tais como digoxina e oubaína, são conhecidos por sua eficácia no tratamento da ...
Schneider, Naira Fernanda Zanchett
core  

Immunological Detection of Cardiac-Glycosides in Plants

, 1994
Australian native and introduced plants were examined, using digoxin immunoassays, to detect the presence of cross-reacting cardiac glycosides. These compounds were found in 27 species from 20 genera. The assay technique can also be used on serum samples
Radford, DJ, Cheung, K, JR GOLLOGLY, Urech, R, R. URECH, Duffy, P, P. DUFFY, DJ RADFORD, K. CHEUNG, Gollogly, JR   +9 more
core   +1 more source

Cardiac Glycoside Oleandrin Suppresses EMT Ability in Endometrial Carcinoma Cells. [PDF]

Int J Mol Cell Med, 2023
Secer Celik F, Eroglu Gunes C, Kurar E.
europepmc   +1 more source

Cardiac glycoside binding sites in cultured heart muscle cells [PDF]

, 1984
Erdmann, E., B. Zwißler, W. Krawietz, E. Erdmann, B. Wagenknecht, Wagenknecht, B., Werdan, K., Zwißler, Bernhard, K. Werdan, Krawietz, W.   +9 more
core   +1 more source

Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status. [PDF]

Cell Commun Signal, 2023
Poohadsuan J, O'Doherty GA, Owattanapanich W, Kungwankiattichai S, Rojanasakul Y, Issaragrisil S, Luanpitpong S.   +6 more
europepmc   +1 more source

Avaliação da atividade anti-herpética de cardenolídeos e derivados [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina. Programa de Pós-Graduação em Biotecnologia, Florianópolis, 2011Os cardenolídeos pertencem a um grupo de compostos naturais, que inibem a bomba de Na+/K+ (NKATPase).
Bertol, Jéssica Wildgrube
core  

Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents.

, 2013
Modulation of the DNA repair pathway is an emerging target for the development of anticancer drugs. DNA interstrand cross-links (ICLs), one of the most severe forms of DNA damage caused by anticancer drugs such as cisplatin and mitomycin C (MMC ...
Soo Kyung Hwang, Dong Wha Jun, Mihwa Hwang, Sunshin Kim (137908), Dong Wha Jun (466916), Hyun Jung Kim, Chang-Hun Lee, Mihwa Hwang (466917), Hyun Jung Kim (182757), Sunshin Kim, Soo Kyung Hwang (466918), Chang-Hun Lee (466919)   +11 more
core   +1 more source

Transcriptome Profiling of Cardiac Glycoside Treatment Reveals EGR1 and Downstream Proteins of MAPK/ERK Signaling Pathway in Human Breast Cancer Cells. [PDF]

Int J Mol Sci, 2023
Pavithran H, Kumavath R, Ghosh P.
europepmc   +1 more source

Genome and Tissue‐Specific Transcriptome of the Tropical Milkweed (Asclepias curassavica)

Plant Direct
Tropical milkweed (Asclepias curassavica) serves as a host plant for monarch butterflies (Danaus plexippus) and other insect herbivores that can tolerate the abundant cardiac glycosides that are characteristic of this species.
Honglin Feng, Jing Zhang, Adrian F. Powell, Gretta L. Buttelmann, Lily Yang, Ethan Yan, Fumin Wang, Steven B. Broyles, Georg Jander, Susan R. Strickler   +9 more
doaj   +1 more source