Results 101 to 110 of about 28,908 (220)

Exploring the anticancer mechanism of cardiac glycosides using proteome integral solubility alteration approach

Cancer Medicine
Background and Aims Cardiac glycosides (CGs), traditionally used for heart failure, have shown potential as anti‐cancer agents. This study aims to explore their multifaceted mechanisms in cancer cell biology using proteome integral solubility alteration (
Wenjie Qin, Yinhua Deng, Huan Ren, Yanling Liu, Ling Liu, Wenhui Liu, Yuxi Zhao, Chen Li, Zhiling Yang   +8 more
doaj   +1 more source

Assessing Research Impact With Bibliometrics and Altmetrics: The Case of the Canadian Network for Observational Drug Effect Studies (CNODES)

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Purpose Our purpose was to measure the research output and impact of the Canadian Network for Observational Drug Effect Studies (CNODES). Methods We used OpenAlex to collect metadata on citation counts for all 115 CNODES articles published between January 2011 and March 2022. We obtained the altmetric scores from Altmetric.com.
Alexandra M. Yip, Ingrid S. Sketris, Samuel A. Stewart, Pauline Reynier, Philippe Mongeon, Kristian B. Filion   +5 more
wiley   +1 more source

Integrating mass spectrometry and systems biology for the modernization of natural medicines: From deciphering chemical complexity to holistic efficacy assessment

VIEW, Volume 7, Issue 2, April 2026.
This review explores how mass spectrometry is transforming research in natural medicines, with Traditional Chinese medicine (TCM) as a primary exemplar. It details the application of advanced mass spectrometry in chemical analysis, the development of comprehensive quality control methods, and systematic research on the targeted mechanisms of single ...
Yudian Xu, Linlin Cao, Chenhuan Ding, Chen Wang, Yi Lai, Dan Ru, He Li, Wei Xu   +7 more
wiley   +1 more source

The Cytotoxic Cardiac Glycoside (-)-Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets. [PDF]

J Nat Prod, 2023
Ren Y, Kaweesa EN, Tian L, Wu S, Sydara K, Xayvue M, Moore CE, Soejarto DD, Cheng X, Yu J, Burdette JE, Kinghorn AD.   +11 more
europepmc   +1 more source

Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Skeletal system diseases, encompassing chronic disorders of the skeletal system which commonly include osteoarthritis, rheumatoid arthritis, osteoporosis and osteosarcoma. Their incidence rates have been increasing in recent years, resulting in significant social and economic burdens.
Qian Yi, Jinye Li, Guotian Luo, Jiachen Li, Dahang Yang, Wei Sun, Weichao Sun, Wei You, Lei Yang   +8 more
wiley   +1 more source

Cardiac Glycoside Oleandrin Suppresses EMT Ability in Endometrial Carcinoma Cells. [PDF]

Int J Mol Cell Med, 2023
Secer Celik F, Eroglu Gunes C, Kurar E.
europepmc   +1 more source

Evaluation of chromosome abberations induced by digoxin in Chinese hamster ovary cells [PDF]

, 2013
Digoxin is a cardiac glycoside that has been reported to inhibit growth of multiple tumor cell types in vitro. The present study was assessing the cytogenetic effects of this drug on Chinese Hamster Ovary (CHO) cells.
Saadat, Iraj, Saadat, Mostafa, Sedigh-Ardekani, Mozhgan   +2 more
core  

Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status. [PDF]

Cell Commun Signal, 2023
Poohadsuan J, O'Doherty GA, Owattanapanich W, Kungwankiattichai S, Rojanasakul Y, Issaragrisil S, Luanpitpong S.   +6 more
europepmc   +1 more source

Antibacterial effects of extracts of Ocimum gratissimum and piper guineense on Escherichia coli and Staphylococcus aureus [PDF]

, 2009
The upsurge in the prevalence of side effects of many synthetic antimicrobial agents and incidence of multidrug resistant bacteria has spurred scientists on the research for plant based antimicrobial of therapeutic potentials.
Ajani, O. O., Chinedu, S. N., Ikpo, C. O., Nwinyi, O. C., Ogunniran, K. O.   +4 more
core  

Transcriptome Profiling of Cardiac Glycoside Treatment Reveals EGR1 and Downstream Proteins of MAPK/ERK Signaling Pathway in Human Breast Cancer Cells. [PDF]

Int J Mol Sci, 2023
Pavithran H, Kumavath R, Ghosh P.
europepmc   +1 more source