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Extracellular vesicular microRNAs and cardiac hypertrophy [PDF]
Frontiers in EndocrinologyCardiac hypertrophy is an adaptive response to pressure or volume overload such as hypertension and ischemic heart diseases. Sustained cardiac hypertrophy eventually leads to heart failure.
Hai Hu +5 more
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MiR-26a-5p inhibits GSK3β expression and promotes cardiac hypertrophy in vitro [PDF]
PeerJ, 2020 Background The role of miR-26a-5p expression in cardiac hypertrophy remains unclear. Herein, the effect of miR-26a-5p on cardiac hypertrophy was investigated using phenylephrine (PE)-induced cardiac hypertrophy in vitro and in a rat model of hypertension-
Liqun Tang +3 more
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Multi-Omics Characterization of a Human Stem Cell-Based Model of Cardiac Hypertrophy
Life, 2022 Cardiac hypertrophy is an important and independent risk factor for the development of cardiac myopathy that may lead to heart failure. The mechanisms underlying the development of cardiac hypertrophy are yet not well understood.
Markus Johansson +6 more
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TRAF Family Member 4 Promotes Cardiac Hypertrophy Through the Activation of the AKT Pathway
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Pathological cardiac hypertrophy is a major cause of heart failure morbidity. The complex mechanism of intermolecular interactions underlying the pathogenesis of cardiac hypertrophy has led to a lack of development and application of ...
Jian Li +7 more
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Frontiers in Pharmacology, 2023 Pathological cardiac hypertrophy is an important risk factor for cardiovascular disease. However, drug therapies that can reverse the maladaptive process and restore heart function are limited. Ganoderma lucidum polysaccharides (GLPs) are one of the main
Changlin Zhen +19 more
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Speckle Tracking Based Strain Analysis Is Sensitive for Early Detection of Pathological Cardiac Hypertrophy. [PDF]
PLoS ONE, 2016 Cardiac hypertrophy is a key pathological process of many cardiac diseases. However, early detection of cardiac hypertrophy is difficult by the currently used non-invasive method and new approaches are in urgent need for efficient diagnosis of cardiac ...
Xiangbo An +7 more
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FOXO3a-dependent PARKIN negatively regulates cardiac hypertrophy by restoring mitophagy
Cell & Bioscience, 2022 Background Sustained cardiac hypertrophy often develops maladaptive myocardial remodeling, and eventually progresses to heart failure and sudden death.
Teng Sun +9 more
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Differential and conditional activation of PKC-isoforms dictates cardiac adaptation during physiological to pathological hypertrophy. [PDF]
PLoS ONE, 2014 A cardiac hypertrophy is defined as an increase in heart mass which may either be beneficial (physiological hypertrophy) or detrimental (pathological hypertrophy).
Shaon Naskar +6 more
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Cell Death Discovery, 2022 s Pathological cardiac hypertrophy is a key contributor in heart failure (HF). Long non-coding RNAs (lncRNAs) and N6-methyladenosine (m6A) modification play a vital role in cardiac hypertrophy respectively.
Yiqing Yang +5 more
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The function of LncRNA-H19 in cardiac hypertrophy
Cell & Bioscience, 2021 Cardiac hypertrophy, characterized by the enlargement of cardiomyocytes, is initially an adaptive response to physiological and pathological stimuli. Decompensated cardiac hypertrophy is related to fibrosis, inflammatory cytokine, maladaptive remodeling,
Wenhua Su +9 more
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