Results 291 to 300 of about 1,441,839 (397)

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Mathematical Modeling to Unmask Mechanisms of Fibrillation in IVF With Cardiac Myocytes From Patients' Induced Pluripotent Cells? [PDF]

JACC Clin Electrophysiol
Agarwal SR, Ajijola OA.
europepmc   +1 more source

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

EMBO Journal, 1993
J. Sadoshima, S. Izumo
semanticscholar   +1 more source

Structure mirroring function: What's the ‘matter’ with the funny current?

The Journal of Physiology, EarlyView.
Abstract figure legend The ‘funny’ (If) current of cardiac pacemaker cells has been first identified in the late 1970s as a major mechanism in the generation and control of cardiac pacemaking. Decades of studies have since described the properties of the funny current and of its molecular components, HCN channels, in the heart and brain, providing the ...
Andrea Saponaro, Dario DiFrancesco
wiley   +1 more source

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

, 2010
Denghong Zhang, Riccardo Contu, Michael V.G. Latronico, Jian Ling Zhang, Roberto Rizzi, Daniele Catalucci, Shigeki Miyamoto, Katherine Huang, Marcello Ceci, Yusu Gu, Nancy D. Dalton, Kirk L. Peterson, Kun‐Liang Guan, Joan Heller Brown, Chen Ju, Nahum Sonenberg, Gianluigi Condorelli   +16 more
openalex   +2 more sources

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti, Rolf Krause, Luca F. Pavarino   +2 more
wiley   +1 more source

Models of cardiomyocyte–non‐myocyte electrical interactions

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiomyocyte–non‐myocyte (CM–NM) electrotonic coupling. Left: conceptual contact‐based interactions between CM and other NM via connexin (Cx) proteins. Three basic scenarios are proposed: (i) ‘zero‐sided coupling’ where there are no electrical connections between CM and NM, (ii) ‘single‐sided coupling’ where NM are connected to ...
Ana Simon‐Chica, Axel Loewe, Peter Kohl   +2 more
wiley   +1 more source

Gap junctional and ephaptic coupling in cardiac electrical propagation: homocellular and heterocellular perspectives

The Journal of Physiology, EarlyView.
Abstract figure legend Intricate cellular electrical coupling networks in the heart. Various cell types couple the central cardiomyocyte through gap junctional contacts, with the exception of neurons. Whether ephaptic coupling (EpC) occurs in homocellular or heterocellular contexts beyond cardiomyocyte–cardiomyocyte interactions remains unclear ...
Xiaobo Wu, Laura Beth Payne, Robert G. Gourdie   +2 more
wiley   +1 more source

Restoration of Defective L-type Ca2+ Current in Cardiac Myocytes of Type 2 Diabetic db/db Mice by Akt and PKC-ι

, 2011
Zhongju Lu, Lisa M. Ballou, Yaping Jiang, Ira S. Cohen, Richard Z. Lin   +4 more
openalex   +2 more sources

Enviromimetics: From exercise mimetics to cognitomimetics in the quest for enhanced brain health and cognition

The Journal of Physiology, EarlyView.
Abstract figure legend A schematic diagram outlining the concept of enviromimetics, and the subclasses of exercise mimetics, epimimetics and cognitomimetics. The rationale is that environmental stimulation and lifestyle factors, including physical activity and cognitive stimulation, have shown beneficial effects across a range of human conditions ...
Anthony J. Hannan
wiley   +1 more source