Results 171 to 180 of about 19,613 (205)

Monitoring treatment with cardiac myosin inhibitors in symptomatic obstructive hypertrophic cardiomyopathy

Current Opinion in Cardiology, 2023
Purpose of review Cardiac myosin inhibitors (CMIs) represent a major milestone in the treatment of patients with symptomatic obstructive hypertrophic cardiomyopathy. The objective of this review is to discuss the mechanisms of action, clinical trial evidence, safety profile and monitoring of CMIs, which are important to the ...
Safia, Chatur, Sheila M, Hegde
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First-in-class cardiac myosin inhibitor reduces symptoms of HCM

Nature Reviews Cardiology, 2020
Mavacamten, a first-in-class cardiac myosin inhibitor, reduces symptoms and improves health status in patients with obstructive hypertrophic cardiomyopathy, according to findings from the EXPLORER-HCM trial.
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The Revolution of Cardiac Myosin Inhibitors in Patients With Hypertrophic Cardiomyopathy

Canadian Journal of Cardiology
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy worldwide and causes significant morbidity and mortality. For decades, medical treatment options have been limited and untargeted, with frequent need for invasive interventions not readily accessible to many HCM patients.
Rebecca Haraf, Hany Habib, Ahmad Masri
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Two cardiac myosin inhibitors in the treatment of obstructive hypertrophic cardiomyopathy

Med
A key area of therapeutic progress in obstructive hypertrophic cardiomyopathy revolves around the emergence of cardiac myosin inhibitors, of which mavacamten and aficamten represent the first and second molecules. We summarize the key research evidence, including many similarities and potential differences between various clinical trials studying these
Milind Y, Desai, Eugene, Braunwald
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Heart of the matter: A GP’s guide to cardiac myosin inhibitors

InnovAiT: Education and inspiration for general practice
Hypertrophic obstructive cardiomyopathy (HOCM) is a heritable heart condition. It causes hypertrophy of the heart muscle and left ventricular outflow tract obstruction. Hypertrophic cardiomyopathy (HCM) is one of the most prevalent inherited cardiac disorders, with more than 1400 mutations discovered.
Naneishvili, Tamara; id_orcid 0000-0001-9577-7186, How, Wei Jun, Andrade, Ivo, Cummins, Samantha, Hutchings, David; id_orcid 0000-0002-5402-8565, Malhotra, Aneil, Venetucci, Luigi, Beynon, Rhys, Crean, Andrew; id_orcid 0000-0002-2038-9178   +8 more
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Recent trend in the therapy of hypertrophic cardiomyopathy: Cardiac myosin inhibitors

2023
Cardiac myosin inhibitors are a new class of drugs that have recently been approved in obstructive hypertrophic cardiomyopathy. The main mechanism of action is to reduce the pathologically increased cardiac hypercontractility. Current drug therapies have not been demonstrated to modify the natural progress of the disease.
DEMİRKIRAN, Cahit, DEMİRYÜREK, Şeniz, DEMİRYÜREK, Abdullah Tuncay   +2 more
openaire   +1 more source

Cardiac Myosin Inhibitors for Obstructive Hypertrophic Cardiomyopathy

Journal of the American College of Cardiology, 2022
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FDA okays first cardiac myosin inhibitor

Nature Biotechnology, 2022
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FDA approves first cardiac myosin inhibitor

Nature Reviews Drug Discovery, 2022
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Cardiac Myosin Inhibitors for Managing Obstructive Hypertrophic Cardiomyopathy

JACC: Heart Failure, 2023
John W. Ostrominski, Ruby Guo, Perry M. Elliott, Carolyn Y. Ho   +3 more
openaire   +1 more source