Results 171 to 180 of about 19,651 (218)

3D skeletal muscle model recapitulating the myostatin knockout phenotypic and mitochondrial metabolic features

Physiological Reports, Volume 14, Issue 12, June 2026.
3D muscle culture reproduces the metabolic characteristics associated with the myostatin knockout phenotype. Abstract 3D cell culture, using a variety of bioengineering techniques, enables muscle cells to be cultured in more structural and functional biomimetic conditions than 2D cell culture.
Barbara Vernus, Elodie Jublanc, Béatrice Chabi, Laurence Pessemesse, Zacharie Cheng‐Boivin, Benoit J. Gentil, Anne Bonnieu, Christelle Koechlin‐Ramonatxo, Bénédicte Goustard   +8 more
wiley   +1 more source

Effect of Mavacamten Therapy on Myocardial Systolic Function Assessed by 3D Echocardiography. [PDF]

JACC Case Rep
Polizzi R, Canciello G, Ordine L, Lombardi R, Esposito G, Losi MA.   +5 more
europepmc   +1 more source

Breaking the Heat Tolerance Response: The Crucial Role of MFAP4 in Combating Heat‐Induced Cardiac Injury

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
MFAP4 deficiency exacerbates heatstroke outcomes, accelerating hyperthermia, delaying recovery, reducing survival, and worsening cardiac injury. Conversely, MFAP4 overexpression enhances cellular thermoresistance. MFAP4 orchestrates transcriptional reprogramming in response to HS.
LiJun Fan, MingXiao Song, QingHan Zhang, ZiYi Guo, Jing Wang, XueWei Chen, ChenYi Hu, JunYu Lu, ZhuGe Xi   +8 more
wiley   +1 more source

Case Report: Mavacamten in mid-ventricular and apical hypertrophic cardiomyopathy-a case of targeted therapy beyond left ventricular outflow tract obstruction. [PDF]

Front Med (Lausanne)
Yang L, Dai H, Rong Y.
europepmc   +1 more source

Aortic Segments‐Depending Hypertensive Remodeling Is Driven by Mitochondrial Fusion Dysfunction

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
A region‐specific protective function of OPA1 within the aortic wall under severe hypertensive stress. ABSTRACT OPA1 haploinsufficiency exacerbates severe hypertension‐induced aortic remodeling in a segment‐specific manner, revealing differential vulnerability between the suprarenal abdominal aorta (SRAA) and the descending thoracic aorta (DTA). In the
Alexis Richard, Alicia Baptista Vicente, Clara Gourhand, Antoine Ducroix, Pauline Robert, Bertrand Toutain, Linda Grimaud, Emilie Vessières, Agnès Toutain‐Barbelivien, Guy Lenaers, Juan‐Manuel Chao de la Barca, Olivier Fouquet, Daniel Henrion, Céline Fassot, Laurent Loufrani   +14 more
wiley   +1 more source

Effect of mavacamten on sudden cardiac death risk scores in obstructive hypertrophic cardiomyopathy. [PDF]

ESC Heart Fail
Usai P, Cariou E, Donal E, Eyharts D, Cohen N, Lucas C, Al Wazzan A, Cherbi M, Itier R, Fournier P, Habib G, Lairez O.   +11 more
europepmc   +1 more source

Mavacamten as an Effective Treatment for HCM With Latent Exercise-Induced Obstruction: A Case Report. [PDF]

Case Rep Cardiol
Murthy N, Diep B, Evans J, Abramov D, Tran D.   +4 more
europepmc   +1 more source

Still at sea: a patient's ongoing journey with non-obstructive hypertrophic cardiomyopathy. [PDF]

Eur Heart J Case Rep
Goldie FC, Myles RC, Coats CJ.
europepmc   +1 more source

Myosin modulator Aficamten inhibits force in cardiac muscle by altering myosin’s biochemical activity without changing thick filament structure [PDF]

Saffie Mohran, Kristina B. Kooiker, Ateeqa Naim, Matvey Pilagov, Anthony Asencio, Kyrah L. Turner, Weikang Ma, Galina Flint, Siyao Jiang, Jing Zhao, Timothy S. McMillen, Christian Mandrycky, Max Mahoney-Schaefer, Thomas C. Irving, Bertrand C.W. Tanner, Neil M. Kad, Michael Regnier, Farid Moussavi‐Harami   +17 more
openalex   +1 more source

Research progress on pathogenic genes of dilated cardiomyopathy. [PDF]

iScience
Zhang X, Zhang X, Chen Y, Huan N, Wang C, Zhang D.   +5 more
europepmc   +1 more source