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Research into the physiology of myosins - a personal odyssey [PDF]
European Journal of Translational MyologyDuring my PhD, I worked on the neural regulation of mechanical properties fast and slow muscles. This led me to believe that myosins in fast and slow muscles are structurally distinct and that motor nerves regulate the expression of myosin genes.
Joseph Foon Yoong Hoh
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Are the class 18 myosins Myo18A and Myo18B specialist sarcomeric proteins? [PDF]
Frontiers in PhysiologyInitially, the two members of class 18 myosins, Myo18A and Myo18B, appeared to exhibit highly divergent functions, complicating the assignment of class-specific functions.
Markus Horsthemke +3 more
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Single cardiac ventricular myosins are autonomous motors [PDF]
Open Biology, 2018 Myosin transduces ATP free energy into mechanical work in muscle. Cardiac muscle has dynamically wide-ranging power demands on the motor as the muscle changes modes in a heartbeat from relaxation, via auxotonic shortening, to isometric contraction.
Yihua Wang +4 more
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The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy [PDF]
, 2008 Background: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies results from sarcomeric protein mutations, including cardiac troponin T (cTnT, TNNT2).
Ahmad, F +17 more
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Cryo-EM structure of the folded-back state of human β-cardiac myosin
Nature Communications, 2023 To save energy and precisely regulate cardiac contractility, cardiac muscle myosin heads are sequestered in an ‘off’ state that can be converted to an ‘on’ state when exertion is increased. The ‘off’ state is equated with a folded-back structure known as
Alessandro Grinzato +10 more
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Therapeutic Advances in Chronic Disease, 2022 Hypertrophic cardiomyopathy (HCM) is a common genetic disorder characterised by unexplained left ventricular hypertrophy. Left ventricular outflow tract obstruction is an integral component of the disease, often resulting in significant symptoms, but ...
Susan Mathai, Lynne Williams
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To lie or not to lie: Super-relaxing with myosins
eLife, 2021 Since the discovery of muscle in the 19th century, myosins as molecular motors have been extensively studied. However, in the last decade, a new functional super-relaxed (SRX) state of myosin has been discovered, which has a 10-fold slower ATP turnover ...
Suman Nag, Darshan V Trivedi
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MYH10 activation rescues contractile defects in arrhythmogenic cardiomyopathy (ACM)
Nature Communications, 2023 The most prevalent genetic form of inherited arrhythmogenic cardiomyopathy (ACM) is caused by mutations in desmosomal plakophilin-2 (PKP2). By studying pathogenic deletion mutations in the desmosomal protein PKP2, here we identify a general mechanism by ...
Nieves García-Quintáns +16 more
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PLoS ONE, 2021 To gain insight on the impact of preventive exercise during pulmonary arterial hypertension (PAH), we evaluated the gene expression of myosins and gene-encoding proteins associated with the extracellular matrix remodeling of right hypertrophied ...
Thaoan Bruno Mariano +11 more
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Molecules, 2022 Milk represents an integrated meal for newborns; its whey protein is rich in many health beneficial components and proteins. The current study aimed to investigate the differences between colostrum and mature milk from Mediterranean and Murrah buffaloes ...
Mahmoud Abdel-Hamid +8 more
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