Results 11 to 20 of about 6,808 (263)

Nanosurfer assay dissects β-cardiac myosin and cardiac myosin-binding protein C interactions

Biophysical Journal, 2022
Cardiac myosin-binding protein C (cMyBP-C) modulates cardiac contractility through putative interactions with the myosin S2 tail and/or the thin filament. The relative contribution of these binding-partner interactions to cMyBP-C modulatory function remains unclear. Hence, we developed a "nanosurfer" assay as a model system to interrogate these cMyBP-C
Anja M. Touma, Wanjian Tang, David V. Rasicci, Duha Vang, Ashim Rai, Samantha B. Previs, David M. Warshaw, Christopher M. Yengo, Sivaraj Sivaramakrishnan   +8 more
openaire   +2 more sources

The ancient sarcomeric myosins found in specialized muscles

Skeletal Muscle, 2019
Striated muscles express an array of sarcomeric myosin motors that are tuned to accomplish specific tasks. Each myosin isoform found in muscle fibers confers unique contractile properties to the fiber in order to meet the demands of the muscle.
Lindsey A. Lee, Anastasia Karabina, Lindsey J. Broadwell, Leslie A. Leinwand   +3 more
doaj   +1 more source

Myosin modulators: emerging approaches for the treatment of cardiomyopathies and heart failure

The Journal of Clinical Investigation, 2022
Myosin modulators are a novel class of pharmaceutical agents that are being developed to treat patients with a range of cardiomyopathies. The therapeutic goal of these drugs is to target cardiac myosins directly to modulate contractility and cardiac ...
Sharlene M. Day, Jil C. Tardiff, E. Michael Ostap   +2 more
doaj   +1 more source

Functional comparison of phosphomimetic S15D and T160D mutants of myosin regulatory light chain exchanged in cardiac muscle preparations of HCM and WT mice

Frontiers in Cardiovascular Medicine, 2022
In this study, we investigated the rescue potential of two phosphomimetic mutants of the myosin regulatory light chain (RLC, MYL2 gene), S15D, and T160D RLCs.
Katarzyna Kazmierczak, Jingsheng Liang, Michelle Gomez-Guevara, Danuta Szczesna-Cordary   +3 more
doaj   +1 more source

Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics

Biology Open, 2021
The fundamental basis of muscle contraction ‘the sliding filament model’ (Huxley and Niedergerke, 1954; Huxley and Hanson, 1954) and the ‘swinging, tilting crossbridge-sliding filament mechanism’ (Huxley, 1969; Huxley and Brown, 1967) nucleated a field ...
Manuel Schmid, Christopher N. Toepfer
doaj   +1 more source

Mechanosensing in myosin filament solves a 60 years old conflict in skeletal muscle modeling between high power output and slow rise in tension [PDF]

, 2016
Almost 60 years ago Andrew Huxley with his seminal paper \cite{Huxley1957} laid the foundation of modern muscle modeling, linking chemical events to mechanical performance.
Marcucci, Lorenzo, Reggiani, Carlo
core   +3 more sources

Aberrant splicing and expression of the non muscle myosin heavy-chain gene MYH14 in DM1 muscle tissues [PDF]

, 2012
Myotonic dystrophy type 1 (DM1) is a complex multisystemic disorder caused by an expansion of a CTG repeat located at the 3' untranslated region (UTR) of DMPK on chromosome 19q13.3.
Angelini, C, Botta, A, Di Girolamo, S, Gourdon, G, Loro, E, Massa, R, Novelli, G, Pisani, V, Rinaldi, F, Terracciano, C, Vergani, L   +10 more
core   +1 more source

Human Cardiac Myosin: Electron Microscopic Observations [PDF]

Circulation Research, 1965
Solutions of human cardiac myosin contain macromolecules which were visualized in the electron microscope by the shadow-casting technic. The dominant particle was observed to be rod-shaped, to have a globular expansion at one end, and to have a mean length of about 1500 Å. The molecule of human cardiac myosin was found to be morphologically similar to
J A, Carney, A L, Brown
openaire   +2 more sources

Binding pocket dynamics along the recovery stroke of human β-cardiac myosin.

PLoS Computational Biology, 2023
The druggability of small-molecule binding sites can be significantly affected by protein motions and conformational changes. Ligand binding, protein dynamics and protein function have been shown to be closely interconnected in myosins.
Fariha Akter, Julien Ochala, Arianna Fornili   +2 more
doaj   +1 more source

Heavy and light roles: myosin in the morphogenesis of the heart [PDF]

, 2012
Myosin is an essential component of cardiac muscle, from the onset of cardiogenesis through to the adult heart. Although traditionally known for its role in energy transduction and force development, recent studies suggest that both myosin heavy-chain ...
A Abu-Daya, A Du, A Horowitz, A Houmeida, A Wessels, AA Lagrutta, AE Chambers, AN Tullio, AS Warkman, AV Postma, B Brenner, BA Danowski, BG Bruneau, BN Davis, BR Cullen, BS Budde, BS Pan, BV Latinkic, C Gove, C Huang, C Rutland, C Wang, CR Bagshaw, CS Rutland, CT Basson, D Franco, D Franco, D Hailstones, D Jin, D Linde van der, D Maughan, D Mornet, D Rhee, D Yelon, DJ Timson, DM Alvarado, DO Fürst, E Berdougo, E Carniel, E Eisenberg, E Flashman, E Rooij van, E Rooij van, EM Small, EP Kirk, F Charron, G Bonne, GE Lyons, H Huxley, H Niimura, H Pannu, H Suzuki, H Wada, HJ Auman, HJ Li, HL Sweeney, HM Warrick, I Morano, I Morano, I Rayment, J Chen, J Fewell, J Flavigny, J Gulick, J Stull, JD Molkentin, Jennifer England, JGF Cleland, JJ Schott, JM Miano, JP Sluijter, JS Davis, JS Park, JT Granados-Riveron, JY Chan, K Imanaka-Yoshida, K Poetter, K Takeda, K Trybus, KD Wilson, KK Turnacioglu, KM Price, KN Ivey, KT Tokuyasu, L Khait, L Zhu, L Zhu, LD Sacks, LM Auckland, M Arad, M Chandra, M Goujon, M Maitra, M Morano, M Xin, MA Geeves, MA Larkin, MC Schaub, MG Posch, MJ Macera, ML Bell, MS Parmacek, N Liu, ND Epstein, ND Moncrief, O Ogut, O Ritter, P Andersen, P Richard, P VanBuren, P Vibert, PFM Ven Van Der, PJ Barton, PJ Barton, PJ Reiser, PS Andersen, Q Shi, QY Li, R Nishigaki, R Walsh, RE Cheney, RE Hershberger, RJ Garriock, RL Moss, RM Toydemir, S Ghatpande, S Goswami, S Lu, S Machida, S Somi, Siobhan Loughna, SJ Smith, SS Lehrer, SW Kubalak, T Boettger, T Takaya, TE Callis, TM Olson, TQP Uyeda, TX O’Brien, V Garg, VJ Ferrans, W Barillot, W Dillmann, W Lehman, W Lu, W Rottbauer, W-H Lee, WF Harrington, WF Harrington, WK Jones, WL Fodor, X Ma, X Ma, Y Hiroi, Y Ishikawa, Y Nakajima, Y Taneda, Y Yang, YH Ching, Z Chen, Z Wang, ZT Kabaeva, ZZ Bao   +163 more
core   +3 more sources