Results 21 to 30 of about 6,808 (263)
Cardiac Myosin Binding Protein C [PDF]
Circulation Research, 1999 Abstract —Myosin binding protein C (MyBP-C) is one of a group of myosin binding proteins that are present in the myofibrils of all striated muscle. The protein is found at 43-nm repeats along 7 to 9 transverse lines in a portion of the A band where crossbridges are found (C zone).
openaire +2 more sources
Novel blood coagulation molecules: Skeletal muscle myosin and cardiac myosin
Journal of Thrombosis and Haemostasis, 2021 Essentials Striated muscle myosins can promote prothrombin activation by FXa or FVa inactivation by APC. Cardiac myosin and skeletal muscle myosin are pro-hemostatic in murine tail cut bleeding models. Infused cardiac myosin exacerbates myocardial injury caused by myocardial ischemia reperfusion.
Deguchi, Hiroshi +2 more
openaire +3 more sources
Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector
Cell Reports, 2015 Cardiomyopathies due to mutations in human β-cardiac myosin are a significant cause of heart failure, sudden death, and arrhythmia. To understand the underlying molecular basis of changes in the contractile system’s force production due to such mutations
Tural Aksel +4 more
doaj +1 more source
Molecular Characteristics of Canine Cardiac Myosin [PDF]
Circulation Research, 1965 Cardiac myosin was obtained from the hearts of normal dogs by conventional extraction and precipitation techniques, followed by ammonium sulfate fractionation in the presence of 2.0 M lithium chloride. The molecular characteristics of this protein preparation are presented. Cardiac myosin prepared by this technique shows less tendency than
R J, LUCHI, E M, KRITCHER, H L, CONN
openaire +2 more sources
The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development [PDF]
, 2015 Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem ...
Anna eNoble +9 more
core +2 more sources
Bioinformatics and Biology Insights, 2012 Myosins are one of the largest protein superfamilies with 24 classes. They have conserved structural features and catalytic domains yet show huge variation at different domains resulting in a variety of functions.
Divya P. Syamaladevi +6 more
doaj +1 more source
Direct regulation of striated muscle myosins by nitric oxide and endogenous nitrosothiols.
PLoS ONE, 2010 BackgroundNitric oxide (NO) has long been recognized to affect muscle contraction, both through activation of guanylyl cyclase and through modification of cysteines in proteins to yield S-nitrosothiols. While NO affects the contractile apparatus directly,
Alicia M Evangelista +7 more
doaj +1 more source
Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells [PDF]
, 2015 Quality of sequences obtained with CASAVA 1.8.1 (Illumina) workflow. PF reads passing Illumina chastity filter.
Christelle Etard +5 more
core +3 more sources
Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties [PDF]
, 2017 In search of myosin II inhibitors with superior research tool properties, a chemical optimization campaign of the blebbistatin scaffold was conducted in this paper. (S)-Blebbistatin is the best known small-molecule inhibitor of myosin II ATPase activity.
Bracke, Marc +6 more
core +1 more source
eLife, 2017 Cardiac β-myosin variants cause hypertrophic (HCM) or dilated (DCM) cardiomyopathy by disrupting sarcomere contraction and relaxation. The locations of variants on isolated myosin head structures predict contractility effects but not the prominent ...
Lorenzo Alamo +6 more
doaj +1 more source