Results 31 to 40 of about 6,808 (263)

MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity [PDF]

, 2016
The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy.
Abraham, Reimar, Agatea, Lisa, Akimoto, Takayuki, Bicciato, Silvio, Blaauw, Bert, Calabria, Elisa, Carvajal, Jaime J., Ciciliot, Stefano, Dyar, Kenneth A., Forcato, Mattia, Moretti, Irene, Murgia, Marta, Pierre, Philippe, Rigby, Peter W. J., Schiaffino, Stefano, Uhlenhaut, N. Henriette   +15 more
core   +5 more sources

Cardiac Myosin-Binding Protein-C Phosphorylation and Cardiac Function [PDF]

Circulation Research, 2005
The role of cardiac myosin binding protein-C (cMyBP-C) phosphorylation in cardiac physiology or pathophysiology is unclear. To investigate the status of cMyBP-C phosphorylation in vivo, we determined its phosphorylation state in stressed and unstressed mouse hearts.
Sakthivel, Sadayappan, James, Gulick, Hanna, Osinska, Lisa A, Martin, Harvey S, Hahn, Gerald W, Dorn, Raisa, Klevitsky, Christine E, Seidman, Jonathan G, Seidman, Jeffrey, Robbins   +9 more
openaire   +2 more sources

Mutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival. [PDF]

, 2016
Folding of the myosin head often requires the joint actions of Hsp90 and a dedicated UNC45, Cro1, She4 (UCS) domain-containing cochaperone protein. Relatively weak sequence conservation exists between the single UCS protein of simple eukaryotes (She4 in ...
Gomez-Escalante, S., Millson, S.H., Piper, P.W.   +2 more
core   +1 more source

Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology [PDF]

Gene, 2015
More than 350 individual MYPBC3 mutations have been identified in patients with inherited hypertrophic cardiomyopathy (HCM), thus representing 40–50% of all HCM mutations, making it the most frequently mutated gene in HCM. HCM is considered a disease of the sarcomere and is characterized by left ventricular hypertrophy, myocyte disarray and diastolic ...
Lucie, Carrier, Giulia, Mearini, Konstantina, Stathopoulou, Friederike, Cuello   +3 more
openaire   +2 more sources

Cardiac myosin binding protein C phosphorylation in cardiac disease [PDF]

Journal of Muscle Research and Cell Motility, 2011
Perturbations in sarcomeric function may in part underlie systolic and diastolic dysfunction of the failing heart. Sarcomeric dysfunction has been ascribed to changes in phosphorylation status of sarcomeric proteins caused by an altered balance between intracellular kinases and phosphatases during the development of cardiac disease.
Kuster DWD, Cholid Bawazeer A, Zaremba R, Goebel M, Boontje NM, van der Velden J.   +5 more
openaire   +4 more sources

Serum Response Factor in muscle tissues: from development to ageing

European Journal of Translational Myology, 2016
Skeletal, cardiac and smooth muscle cells share various common characteristic features. During development the embryonic mesodermal layer contribute at different proportions to the formation of these tissues.
Dario Coletti, Nissrine Daou, Medhi Hassani, Zhenlin Li, Ara Parlakian   +4 more
doaj   +1 more source

Hypertrophic cardiomyopathy: Translating cellular cross talk into therapeutics [PDF]

, 2013
Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with serious adverse outcomes, including heart failure, arrhythmias, and sudden cardiac death.
Padera, Robert Francis, Seidman, Christine Edry, Seidman, Jonathan G., Teekakirikul, Polakit   +3 more
core   +1 more source

Myosin tails and single α-helical domains [PDF]

, 2015
The human genome contains 39 myosin genes, divided up into 12 different classes. The structure, cellular function and biochemical properties of many of these isoforms remain poorly characterized and there is still some controversy as to whether some ...
Batchelor, M, Dougan, L, Knight, PJ, Paci, E, Peckham, M, Wolny, M   +5 more
core   +1 more source

Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits

Molecular Brain, 2018
The alpha1 (α1) subunit of the sodium/potassium ATPase (i.e., Na+/K+-ATPase α1), the prototypical sodium pump, is expressed in each eukaryotic cell. They pump out three sodium ions in exchange for two extracellular potassium ions to establish a cellular ...
Bhagirathi Dash, Sulayman D. Dib-Hajj, Stephen G. Waxman   +2 more
doaj   +1 more source

Cardiac Myosin Adenosinetriphosphatase Activity [PDF]

Circulation Research, 1966
Cardiac myosin prepared by any one of a number of modifications of the basic Szent-Gyorgyi method and cardiac myosin prepared by the lithium chloride-ammonium sulfate technique differ in two important respects: 1) Szent-Gyorgyi-prepared myosin solutions are inhomogeneous by both chemical and immunologic criteria; 2) the ATPase activity of Szent-Gyorgyi-
R J, Luchi, E M, Kritcher
openaire   +2 more sources