Results 61 to 70 of about 1,102,241 (353)

Multicellular 3D models to study myocardial ischemia–reperfusion injury

Frontiers in Cell and Developmental Biology
Coronary heart disease is a major global health threat, with acute myocardial ischemia–reperfusion injury (IRI) being a major contributor to myocardial damage following an ischemic event.
Merel Peletier, Merel Peletier, Xiaohan Zhang, Xiaohan Zhang, Scarlett Klein, Scarlett Klein, Jeffrey Kroon, Jeffrey Kroon, Jeffrey Kroon, Jeffrey Kroon   +9 more
doaj   +1 more source

Myocardial infarction primes autoreactive T cells through activation of dendritic cells [PDF]

, 2017
Peripheral tolerance is crucial for avoiding activation of self-reactive T cells to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it is unclear how autoreactive T cells get activated in response to self. An example
Bouché, Ann, Carmeliet, Peter, De Prijck, Sofie, Gillebert, Thierry, Guilliams, Martin, Lambrecht, Bart, Ludewig, Burkhard, Martens, Liesbet, Nindl, Veronika, Saeys, Yvan, Scott, Charlotte, Sichien, Dorine, Van Der Borght, Katrien, Van Moorleghem, Justine, Vanheerswynghels, Manon   +14 more
core   +6 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Geometric characteristics of bicuspid aortic valvesCentral MessagePerspective

JTCVS Techniques, 2021
Objective: We studied the coaptation angles α and β in bicuspid aortic valve geometry from computed tomography scan images. Methods: In 45 patients, we calculated the coaptation angle α (the angle between the nonfused commissures crossing the center of ...
Jan Nijs, MD, Babs Vangelder, MD, Kaoru Tanaka, MD PhD, Sandro Gelsomino, MD, PhD, FESC, Ines Van Loo, MD, Mark La Meir, MD, PhD, Jos Maessen, MD, PhD, Bas L.J.H. Kietselaer, MD, PhD   +7 more
doaj   +1 more source

Model of murine ventricular cardiac tissue for in vitro kinematic-dynamic studies of electromagnetic and beta2-adrenergic stimulation [PDF]

, 2017
In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 μM), and their combination.
Cornacchione, Marisa, Fassina, Lorenzo, Gimmelli, Roberto, Isidori, Andrea M, Lenzi, Andrea, Magenes, Giovanni, Mognaschi, MARIA EVELINA, Naro, Fabio, Pellegrini, Manuela   +8 more
core   +2 more sources

Challenges in Cardiac Tissue Engineering [PDF]

Tissue Engineering Part B: Reviews, 2010
Cardiac tissue engineering aims to create functional tissue constructs that can reestablish the structure and function of injured myocardium. Engineered constructs can also serve as high-fidelity models for studies of cardiac development and disease. In a general case, the biological potential of the cell-the actual "tissue engineer"-is mobilized by ...
Gordana, Vunjak-Novakovic, Nina, Tandon, Amandine, Godier, Robert, Maidhof, Anna, Marsano, Timothy P, Martens, Milica, Radisic   +6 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches? [PDF]

, 2017
Heart disease is a major cause of morbidity and mortality throughout the world. Some cardiovascular conditions can be modulated by lifestyle factors such as increased exercise or a healthier diet, but many require surgical or pharmacological ...
Agra, Agra, Alexander, Alexander, Alexander, Alexopoulos, Arora, Baessler, Bakkum, Balcioglu, Berridge, Berry, Bers, Bers, Bełtowski, Bian, Burgeiro, Burridge, Castro, Chechi, Cheng, Chilukoti, Chiu, Daya, Dekker, Deng, Deng, Dobrzynski, Dong, Du, Eisner, Elie, Elisha, Engler, Fain, Fandino-Vaquero, Fernandez-Trasancos, Fosshaug, Frankel, Furuhashi, Gaborit, Gaborit, Gao, Georgiou, Ghantous, Gho, Goncalves, Greif, Greulich, Greulich, Greulich, Gruen, Guauque-Olarte, Haemers, Harada, Hassan, Hatem, Hatem, Hatem, Heijman, Heijman, Hua, Hung, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Imoto-Tsubakimoto, Iozzo, Itoh, Janik, Karastergiou, Kaushik, Kazumi, Kim, Kim, Kitagawa, Kleinz, Kusayama, Lage, Lamounier-Zepter, Lamounier-Zepter, Langheim, Leeper, Li, Lim, Lip, Look, MacQueen, Maghbooli, Mahabadi, Mahabadi, Marchington, Marchington, Margaritis, Martinsen, Matloch, Mattacks, Mattacks, Mattacks, Mazurek, Mazurek, Mazzoccoli, McAninch, Mookadam, Nakanishi, Nevelsteen, Nicholls, O'Connell, Pang, Paolisso, Parisi, Pezeshkian, Phillips, Pierdomenico, Pond, Pontes Soares, Prati, Rabkin, Rachwalik, Rainwater, Rajapurohitam, Rodriguez-Penas, Sacks, Sacks, Sacks, Sade, Salgado-Somoza, Samanta, Sarin, Scimia, Shapira-Schweitzer, Shibasaki, Shimabukuro, Siegel-Axel, Silaghi, Smith, Song do, Southan, Spiroglou, Szokodi, Takebayashi, Talman, Teijeira-Fernandez, Vacca, Venteclef, Viscogliosi, Voigt, Vural, Weikert, Westcott, White, Willens, Wong, Xu, Yamaguchi, Yañez-Rivera, Ye, Yilmaz, Zdychova, Zeng, Zhou   +164 more
core   +1 more source

Tissue Characterization in Cardiac Amyloidosis

Biomedicines, 2022
Cardiac amyloidosis (CA) has long been considered a rare disease, but recent advancements in diagnostic tools have led to a reconsideration of the epidemiology of CA. Amyloid light-chain (AL) and transthyretin (ATTR) amyloidoses are the most common forms of cardiac amyloidosis.
Veronica Musetti, Francesco Greco, Vincenzo Castiglione, Alberto Aimo, Cataldo Palmieri, Dario Genovesi, Assuero Giorgetti, Michele Emdin, Giuseppe Vergaro, Liam A. McDonnell, Angela Pucci   +10 more
openaire   +4 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source