Results 51 to 60 of about 86,066 (247)

Application of biomaterials in cardiac tissue engineering: Current status and prospects

MedComm – Biomaterials and Applications
Cardiovascular diseases have become one of the leading causes of death and illness worldwide, posing significant challenges to global health. Due to the limited regenerative capacity of the heart, conventional approaches to treating heart diseases have ...
Dongshan Zhang, Rui He, Ying Qu, Chuan He, Bingyang Chu   +4 more
doaj   +1 more source

Cardiac tissue engineering: state-of-the-art methods and outlook

Journal of Biological Engineering, 2019
The purpose of this review is to assess the state-of-the-art fabrication methods, advances in genome editing, and the use of machine learning to shape the prospective growth in cardiac tissue engineering.
Anh H. Nguyen, Paul Marsh, Lauren Schmiess-Heine, Peter J. Burke, Abraham Lee, Juhyun Lee, Hung Cao   +6 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications

Bioengineering, 2020
Tissue engineering (TE) combines cells, scaffolds, and growth factors to assemble functional tissues for repair or replacement of tissues and organs. Cardiac TE is focused on developing cardiac cells, tissues, and structures—most notably the heart.
Taylor Cook Suh, Alaowei Y. Amanah, Jessica M. Gluck   +2 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Physiological aspects of cardiac tissue engineering [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2012
Cardiac tissue engineering aims at repairing the diseased heart and developing cardiac tissues for basic research and predictive toxicology applications. Since the first description of engineered heart tissue 15 years ago, major development steps were directed toward these three goals.
Thomas, Eschenhagen, Alexandra, Eder, Ingra, Vollert, Arne, Hansen   +3 more
openaire   +2 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Generation of a large-scale vascular bed for the in vitro creation of three-dimensional cardiac tissue

Regenerative Therapy, 2019
Introduction: The definitive treatment for severe heart failure is transplantation. However, only a small number of heart transplants are performed each year due to donor shortages.
Akitoshi Inui, Hidekazu Sekine, Kazunori Sano, Izumi Dobashi, Azumi Yoshida, Katsuhisa Matsuura, Eiji Kobayashi, Minoru Ono, Tatsuya Shimizu   +8 more
doaj   +1 more source

Electroactive Polymeric Composites to Mimic the Electromechanical Properties of Myocardium in Cardiac Tissue Repair

Gels, 2021
Due to the limited regenerative capabilities of cardiomyocytes, incidents of myocardial infarction can cause permanent damage to native myocardium through the formation of acellular, non-conductive scar tissue during wound repair.
Kaylee Meyers, Bruce P. Lee, Rupak M. Rajachar   +2 more
doaj   +1 more source

Biomimetic approach to cardiac tissue engineering [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2007
Here, we review an approach to tissue engineering of functional myocardium that is biomimetic in nature, as it involves the use of culture systems designed to recapitulate some aspects of the actualin vivoenvironment. To mimic the capillary network, subpopulations of neonatal rat heart cells were cultured on a highly porous elastomer scaffold with a ...
M, Radisic, H, Park, S, Gerecht, C, Cannizzaro, R, Langer, G, Vunjak-Novakovic   +5 more
openaire   +2 more sources