Results 101 to 110 of about 53,087 (243)

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Clinical and pathogenetic value of immune disruptions in manifestation of mixed cryoglobulinemia in patients with chronic hepatitis C

Zaporožskij Medicinskij Žurnal, 2018
Objective – to discover role of immune disorders in clinical manifestations formation of mixed cryoglobulinemia in patients with CHC. Material and methods. 214 patients with CHC were included in the study.
O. O. Furyk, Yu. Yu. Riabokon, E. V. Riabokon   +2 more
doaj   +1 more source

Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure. [PDF]

, 2019
The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population.
Alex, Linda, Baines, Christopher P, Domeier, Timothy L, Edwards, Jenna C, Emter, Craig A, Ferreira-Nichols, Stephanie C, Ford, David A, Gao, Chen, Ivey, Jan R, Jones, John L, Jurrissen, Thomas J, Klutho, Paula J, Krenz, Maike, McDonald, Kerry S, Olver, T Dylan, Padilla, Jaume, Rau, Christoph, Rector, R Scott, Solaro, R John, Thorne, Pamela K, Veteto, Adam B, Wang, Yibin, Warren, Chad M   +22 more
core  

The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane. [PDF]

, 2018
Mitochondria are cellular organelles with crucial functions in the generation and distribution of ATP, the buffering of cytosolic Ca2+ and the initiation of apoptosis. Compounds that interfere with these functions are termed mitochondrial toxins, many of
Anand, Ruchika, Barbian, Andreas, Berleth, Niklas, Borchardt, Andrea, Böhler, Philip, Böhler, Philip, Deitersen, Jana, Frank, Marian, García-Sáez, Ana J, Itskanov, Samuel, Kondadi, Arun Kumar, Luyten, Tomas, Niemann, Hendrik, Parys, Jan B, Peña-Blanco, Aida, Proksch, Peter, Reichert, Andreas S, Schlütermann, David, Stork, Björn, Stuhldreier, Fabian, van der Bliek, Alexander M, Wallot-Hieke, Nora, Weidtkamp-Peters, Stefanie, Wesbuer, Elisabeth, Wesselborg, Sebastian, Wu, Wenxian   +25 more
core   +2 more sources

Investigation into the delivery and evaluation of a unique Avena sativa (Oat) Lipid Extract on skin barrier using LC‒MS/MS, Raman spectroscopy, immunostaining analysis and skin efficacy

International Journal of Cosmetic Science, EarlyView.
Abstract Objectives Oat lipids are rich in ceramides. In this investigation, we analysed the delivery of a specific Oat Lipid Extract derived from Avena sativa, comprising ‘skin identical’ ratios of fatty acids, ceramides and cholesterol/sterol. This investigation is the first reported investigation of oat lipids utilizing Raman spectroscopy for the ...
E. Gombert, C. Dewis
wiley   +1 more source

N-acylated peptides derived from human lactoferricin perturb organization of cardiolipin and phosphatidylethanolamine in cell membranes and induce defects in Escherichia coli cell division.

PLoS ONE, 2014
Two types of recently described antibacterial peptides derived from human lactoferricin, either nonacylated or N-acylated, were studied for their different interaction with membranes of Escherichia coli in vivo and in model systems.
Dagmar Zweytick, Bostjan Japelj, Eugenia Mileykovskaya, Mateja Zorko, William Dowhan, Sylvie E Blondelle, Sabrina Riedl, Roman Jerala, Karl Lohner   +8 more
doaj   +1 more source

Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex [PDF]

, 2012
The bacterial ATPase SecA and protein channel complex SecYEG form the core of an essential protein translocation machinery. The nature of the conformational changes induced by each stage of the hydrolytic cycle of ATP and how they are coupled to protein ...
Alice Robson, Bauer, Berger, Bessonneau, Breyton, Brundage, Cannon, Dalal, Deville, Ding, Duong, Egea, Erlandson, Erlandson, Gelis, Gold, Gold, Gold, Hizlan, Hunt, Ian Collinson, Karamanou, Lill, Or, Osborne, Osborne, Park, Park, Piggot, Piggot, Richard B. Sessions, Robson, Robson, Robson, Sarah Whitehouse, Tam, Van den Berg, Vicki A.M. Gold, William J. Allen, Wolf, Woodbury, Zimmer, Zimmer   +42 more
core   +2 more sources

The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2009
In this review article, we summarize the current state of biophysical knowledge concerning the phase behavior and organization of cardiolipin (CL) and CL-containing phospholipid bilayer model membranes. We first briefly consider the occurrence and distribution of CL in biological membranes and its probable biological functions therein. We next consider
Lewis, Ruthven N.A.H., McElhaney, Ronald N.   +1 more
openaire   +2 more sources

Chronic Ulcer on the Vulva

JEADV Clinical Practice, EarlyView.
Farhanaz Panjshiri, Reed Gioe, Carole Bitar   +2 more
wiley   +1 more source

Plant Peptides on the Rise: From Historical Insight to Future Applications

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant peptides constitute a rapidly expanding class of signalling molecules essential to plant physiology, mediating key processes such as development, stress adaptation, and immune responses. This review traces the history of plant peptide research, from the seminal discovery of systemin to the recent identification of non‐canonical peptides (
Shunxi Wang, Jinghua Zhang, Minghui Chen, Bokai Zhang, Huina Zhao, Liuji Wu   +5 more
wiley   +1 more source