Results 91 to 100 of about 4,774 (217)
Cardiolipin‐dependent Carriers
The FASEB Journal, 2021 The phospholipid, cardiolipin, has pleiotropic structural and functional roles that are collectively essential for mitochondrial biology. Yet, the molecular details of how this lipid supports the structure and function of proteins and protein complexes is poorly understood.
openaire +1 more source
Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review
British Journal of Pharmacology, EarlyView.Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos +16 more
wiley +1 more source
Archaeosomes made of Halorubrum tebenquichense total polar lipids: A new source of adjuvancy [PDF]
, 2009 Background: Archaeosomes (ARC), vesicles prepared from total polar lipids (TPL) extracted from selected genera and species from the Archaea domain, elicit both antibody and cell-mediated immunity to the entrapped antigen, as well as efficient cross ...
González, Raúl O. +9 more
core +1 more source
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová +12 more
wiley +1 more source
Journal of Lipid Research, 1998 Cardiolipin species substituted on O2 of the middle glycerol moiety with α-d-glucopyranosyl, d-alanyl and l-lysyl residues were isolated from different gram-positive bacteria. There respective structures were elucidated by positive and negative mode fast
J. Peter-Katalinic, W. Fischer
doaj +1 more source
Dietary Omega-3 Fatty Acids Do Not Change Resistance of Rat Brain or Liver Mitochondria to Ca2+ and/or Prooxidants [PDF]
, 2012 Omega-3 polyunsaturated fatty acids (n-3 PUFAs) block apoptotic neuronal cell death and are strongly neuroprotective in acute and chronic neurodegeneration.
Baranov, Sergei V. +6 more
core +3 more sources
Mitochondrial Transfer in the Tumor Microenvironment
Cancer Science, EarlyView.Mitochondria are actively exchanged among tumor, immune, stromal, and neuronal cells within the tumor microenvironment. Such transfer rewires tumor metabolism, promotes immune evasion, and drives therapy resistance. Targeting mitochondrial transfer or harnessing mitochondrial transplantation represents a promising strategy to restore antitumor immunity
Ryo Omae +2 more
wiley +1 more source
Among the distinct molecular signatures present in the mitochondrion is the tetra-acylated anionic phospholipid cardiolipin, a lipid also present in primordial, single-cell bacterial ancestors of mitochondria and multiple bacterial species today ...
core
Unusual butane- and pentanetriol-based tetraether lipids in Methanomassiliicoccus luminyensis, a representative of the seventh order of methanogens [PDF]
, 2016 Author Posting. © The Author(s), 2016. This is the author's version of the work. It is posted here by permission of American Society for Microbiology for personal use, not for redistribution.
Becker, Kevin W. +5 more
core +1 more source
The FEBS Journal, EarlyView.Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump +10 more
wiley +1 more source