Results 91 to 100 of about 8,226 (286)
JEADV Clinical Practice, EarlyView.ABSTRACT Multiple myeloma (MM) is a malignant plasma cell disorder that primarily presents with CRAB symptoms (calcium elevation, renal failure, anemia, and bone abnormalities). In rare cases, MM manifests with systemic complications like skin ulcers, which present management challenges. Here, we report a 78‐year‐old Japanese man with MM and refractory
Naoko Hattori +5 more
wiley +1 more source
Dysfunctional copper homeostasis in Caenorhabditis elegans affects genomic and neuronal stability
Redox Biochemistry and ChemistryWhile copper (Cu) is an essential trace element for biological systems due to its redox properties, excess levels may lead to adverse effects partly due to overproduction of reactive species. Thus, a tightly regulated Cu homeostasis is crucial for health.
Ann-Kathrin Weishaupt +9 more
doaj +1 more source
Focal Targeting of the Bacterial Envelope by Antimicrobial Peptides
Frontiers in Cell and Developmental Biology, 2016 Antimicrobial peptides (AMPs) are utilized by both eukaryotic and prokaryotic organisms. AMPs such as the human beta defensins, human neutrophil peptides, human cathelicidin, and many bacterial bacteriocins are cationic and capable of binding to anionic ...
Rafi eRashid +2 more
doaj +1 more source
Archaeosomes made of Halorubrum tebenquichense total polar lipids: A new source of adjuvancy [PDF]
, 2009 Background: Archaeosomes (ARC), vesicles prepared from total polar lipids (TPL) extracted from selected genera and species from the Archaea domain, elicit both antibody and cell-mediated immunity to the entrapped antigen, as well as efficient cross ...
González, Raúl O. +9 more
core +1 more source
Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids
Movement Disorders, EarlyView.Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley +1 more source
The variable domain from dynamin‐related protein 1 promotes liquid–liquid phase separation that enhances its interaction with cardiolipin‐containing membranes [PDF]
, 2023 Ammon E. Posey +10 more
openalex +1 more source
Dietary Omega-3 Fatty Acids Do Not Change Resistance of Rat Brain or Liver Mitochondria to Ca2+ and/or Prooxidants [PDF]
, 2012 Omega-3 polyunsaturated fatty acids (n-3 PUFAs) block apoptotic neuronal cell death and are strongly neuroprotective in acute and chronic neurodegeneration.
Baranov, Sergei V. +6 more
core +3 more sources
Cardiolipin‐dependent Carriers
The FASEB Journal, 2021 The phospholipid, cardiolipin, has pleiotropic structural and functional roles that are collectively essential for mitochondrial biology. Yet, the molecular details of how this lipid supports the structure and function of proteins and protein complexes is poorly understood.
openaire +1 more source
Nano Select, EarlyView.Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri +2 more
wiley +1 more source
Journal of Lipid Research, 1998 Cardiolipin species substituted on O2 of the middle glycerol moiety with α-d-glucopyranosyl, d-alanyl and l-lysyl residues were isolated from different gram-positive bacteria. There respective structures were elucidated by positive and negative mode fast
J. Peter-Katalinic, W. Fischer
doaj +1 more source